Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"chitosan nanoparticles"”.
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Neuroprotection by Chitosan and Chitosan Nanoparticles
… explorations of the neuroprotection by chitosan and chitosan nanoparticles (Chi-NPs) in SCI related cell and tissue studies, we further investigated the neuroprotective effects based on two major characteristics of chitosan: (1) molecular weight (MW) and (2) degree of acetylation (DA). …
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Development of Aerosolizable mRNA Incorporated Chitosan Nanoparticles for Efficient Lung Delivery
… within the respiratory tract. The use of nanoparticles for mRNA delivery to the lungs opens a promising way for treating a wide variety of pulmonary disorders, including genetic and infectious diseases. Chitosan-tripolyphosphate (CS-TPP) nanoparticles present promising opportunities due to …
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Photodynamically Activated Multifunctional Chitosan Nanoparticles to Disinfect and Improve Structural Stability of Dentin
… are twofold: 1) develop and test functionalized nanoparticles to eliminate biofilm bacteria and, 2) to stabilize and strengthen the dentin organic matrix by crosslinking collagen fibrils in the presence of biopolymeric nanoparticles. A bioactive polymeric nanoparticle functionalized with a …
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CHITOSAN PARTICLES FOR THE CONTROLLED RELEASE OF PROTEINS
Back Ground Chitosan as a natural polymer has been fabulated into a number of formulations such as films, hydrogels and particles based on its excellent properties such as biodegradable, biocompotable, bioadhesive, permeartion-enhancement, antibiotic, antitumor etc. properties. Among them, chitosan …
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Multifunctional Nanoparticles for Cancer Therapy
… present study was to develop and characterize nanoparticles containing two anticancer agents having different mechanisms of action that would target both differentiated as well as cancer stem cells. The two hydrophobic antitumor agents (cyclopamine and paclitaxel) were entrapped in glyceryl …
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Obtenção e avaliação do potencial imunoadjuvante de nanopartículas de quitosana na produção de antissoro contra a peçonha da serpente Crotalus durissus cascavella
… small and narrow-sized cationic CDC venom-loaded chitosan nanoparticles (CHNP), by the two association method: adsorption and incorporation, able to induce antibody response against the CDC venom. The ionic gelation method induced the formation of stable and slightly smooth spherical nanoparticles …
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Control of Inflammation Using Drug Delivery Strategies in in vitro Models
… the adaptation of polysialic acid-N-trimethyl chitosan nanoparticles to be used as delivery vehicles for an NF-κB TFD treatment in in vitro models of rheumatoid arthritis and cystic fibrosis.</p>
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Method Optimization and Formulation of Chitosan Nanoparticle for PRPF31 Gene Delivery
… delivery remains a significant challenge. Chitosan (CS) nanoparticles (NPs) offer a promising solution due to their biocompatibility and potential for gene delivery. This study aims to develop a chitosan NP-based delivery system for the PRPF31 gene in the treatment of RP. The plasmid DNA …
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Cancer Associated Fibroblast Derived Angiogenic Factor Mfap5 In Ovarian Cancer Progression
… targeting stromal MFAP5 using siRNA incorporated chitosan nanoparticles significantly reduced tumor growth, metastasis and intratumoral microvessel density. Further, pathway analyses and western blot analyses demonstrated that CAF-derived MFAP5 modulates ovarian cancer cell motility and invasion …
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Nano-engineered polymers in drug delivery: Potential approaches for attenuation of secondary injury after spinal cord trauma
… strategies by delivering siRNA conjugated chitosan nanoparticles to the spinal cord lesion. These siRNAs can specifically knockdown inducible nitric oxide synthase and subsequently eliminate nitric oxide induced secondary injury. This drug delivery system were designed to discriminate …
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Natural antimicrobial nanomaterials for food packaging applications
… NAMs include: antimicrobial polysaccharides (chitosan (CS)), plant essential oils (oregano essential oil (OEO)), and organic acids (sorbic and benzoic acid). To this end, chitosan nanoparticles (CS NPs) were synthesised and the effects of the initial concentrations of chitosan (CS) and sodium …
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Osteogenic Scaffolds for Enhanced Graft-Bone Integration in Ligament Tissue Engineering
… with 1) electrospun fiber scaffolds or 2) nanoparticles that could be combined with electrospun fiber scaffolds, and 3) to develop model three-dimensional fiber-hydrogel composites that support cell viability and proliferation. Two approaches were utilized to present the trophic factor bone …