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Showing 1 to 20 of 29 for “"chiral recognition"”.
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Investigations of Chiral Recognition Processes
… (CEC), was also investigated. The chiral selector was bonded to silica support (3 mum, 100 A pore size), packed into capillaries (100 mum i.d.), and evaluated under different conditions to determine optimal chromatographic performance.
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Spectroscopic and chromatographic investigations of chiral recognition processes
Mechanistic investigations of several chiral stationary phases (CSPs) were undertaken. These investigations were carried out in an effort to understand the recognition processes responsible for the observed enantioselectivities on the CSPs of interest. Several spectroscopic and chromatographic …
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Chromatographic, Spectroscopic and Crystallographic Investigations of Chiral Recognition Processes
… of our recently developed low-molecular weight chiral selectors are capable of differentiating analyte enantiomers. When covalently linked to silica, these chiral selectors are capable of affording chromatographic enantioseparations. Series of homologous analytes were prepared and …
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Investigations of chiral recognition of conformationally rigid chiral stationary phases
… the development of conformationally rigid chiral stationary phases (CSPs) has been a goal. Several conformationally rigid CSPs derived from $\alpha$-amino-lactams have been prepared and their abilities to separate the enantiomers of a variety of analytes have been evaluated. $\pi$-Acidic …
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Elucidation Of Chiral Recognition Mechanisms Of Solutes By Amylose Tris[(s)-Alpha-Methylbenzylcarbamate] Sorbent
<p>Enantioselective separations of chiral molecules are important in various chemical fields, such as pharmaceuticals and agrochemicals industries. Polysaccharide-based sorbents have been widely used in chiral liquid chromatography. The recognition mechanisms which determine their …
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Chiral Separations on HPLC Derivatized Polysaccharide CSPs: Temperature, Mobile Phase and Chiral Recognition Mechanism Studies
Direct chiral separations of the non-steroidal drugs of 2-methylarylpropionic acids (profens) on the chiral stationary phases (CSPs) of amylose tris(3,5-dimethylphenyl-carbamate), Chiralpak AD, and cellulose tris(3,5-dimethylphenylcarbamate), Chiralcel OD, were investigated. Chiralpak AD and …
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Investigations of molecular recognition processes
The use of chiral stationary phases (CSPs) for the separation of enantiomers is commonplace. A variety of $\alpha$-alkyl and $\alpha$-aryl substituted $\alpha$-amino phosphonates were prepared. The ability of several CSPs to separate the enantiomers of N-(3,5-dinitrobenzoyl) derivatives of …
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Design, synthesis, and evaluation of conformationally rigid naproxen chiral selectors
Conformationally rigid naproxen chiral selector are designed and synthesized based on our chiral recognition hypothesis. When bonded to silica, this type of chiral selectors of rigid conformation are evaluated chromatographically and demonstrate enhanced enantioselectivity towards naproxen and …
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Bulk synthesis of two-dimensional polymers
… (2D) polymers. Two different approaches, the chiral recognition approach and the hairpin approach, have been used for the ""bulk preparation of the two-dimensional polymers""."
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Enantioselective Adsorption of 1,3-Dithiolane-1-Oxides and Related Compounds on Liquid Chromatographic Amino Acid-Derived Chiral Stationary Phases (Resolution, Enantiomers, Sulfoxides)
Chiral stationary phases derived from N-3,5-dinitrobenzoyl amino acids such as (R)-phenylglycine, (S)-leucine, (S)-phenylalanine and (S)-valine bonded to aminopropyl silanized silica are employed for preparative and analytical liquid chromatographic separation of the enantiomers of …
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Chiral expression at the nanoscale origin and recognition of chirality
Chirality, familiar to all chemists, is usually applied to molecules or assemblies of molecules and plays an important role in both animate and inanimate systems. It is commonly the case that chirality of a system arises from a chiral building block yet chiral systems can also emerge from achiral …
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A Rational Approach to the Design of Highly Effective Chiral Stationary Phases
… on a chromatography column containing a chiral stationary phase is emerging as an outstanding technique for the determination of enantiomeric purity, the assignment of absolute configuration and the preparative resolution of enantiomers. The continued growth of this technique depends upon …
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Dispersed and deposited polyelectrolyte complexes and their interactions to chiral compounds and proteins
… complexation in the field of low molecular chiral compound and high molecular protein binding. Due to the rapidly growing demands for preparing optically pure compounds in the pharmaceutical field, herein, enantiospecific PEM and PEC were prepared using chiral polyelectrolytes (e.g. …
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Mechanistic Aspects of Enantioselective Complexation
… of synthetic, brush-type liquid chromatographic chiral stationary phases (CSPs) has been investigated. The design and evaluation of a new family of $\pi$-basic CSPs which utilize these intercalative effects to enhance enantioselectivity is discussed. These CSPs, designed from mechanistic …
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A Study of the Interactions Involved in the Direct Liquid Chromatographic Resolution of Racemates
The direct resolution of racemates upon a chiral stationary phase (CSP) is becoming a widely used technique. In order to prepare more effective and more specific CSPs, the rationale for resolution should be better understood. Two chiral recognition models of considerable scope are proposed for the …
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Design, Synthesis, and Applications of Chiral Stationary Phases
… separation of the enantiomers upon a chiral stationary phase. The aim of this research was to develop efficient and widely useful chiral stationary phases. Our approach to this problem was to synthesize a series of specific chiral compounds containing three sites for potential use in …
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THE CONSTRUCTION OF NAPHTHOTUBES AND THEIR APPLICATIONS IN MOLECULAR RECOGNITION, ENANTIOSELECTIVE RECOGNITION AND CHARGE TRANSFER
The molecular recognition of macrocyclic hosts plays a critical role in their functions in supramolecular chemistry and biological systems. However, the understanding of molecular recognition remains limited. Herein, a series of new macrocyclic hosts (naphthotubes) with the deep hydrophobic cavity, …
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Separation, Enantiorecognition, and Chiral Stationary Phase Design of Organophosphonates
Mechanistic investigations of several chiral stationary phases (CSPs) were undertaken. These investigations were carried out in an effort to understand the recognition processes responsible for the observed enantioselectivities on the CSPs of interest. Several spectroscopic and chromatographic …
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Preparation and evaluation of several new pi-basic chiral stationary phases
Several new chiral stationary phases (CSPs) derived from $\alpha$-arylalkylamines and N-arylamino acids are evaluated based on their chromatographic performance. These new chiral stationary phases are useful for separation of the enantiomers of N-(3,5-dinitrobenzoyl) derivatized $\alpha$- and …
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Design and utilization of chiral selectors for enantioselective membrane transport
Systematic investigations of chiral recognition mechanisms have led to chiral selectors which, when immobilized and used as chromatographic stationary phases, show high levels of enantioselectivity. Since these selectors are designed to function in essentially the same manner whether immobilized or …
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