Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"chiral molecules"”.
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Development of porphyrin tweezer system for determining absolute configuration of chiral molecules via ECCD
… SYETEM FOR DETERMINING ABSOLUTE CONFIGURATION OF CHIRAL MOLECULES VIA ECCDByXiaoyong Li This dissertation focuses on three parts. The first portion introduces the concept of exciton coupled circular dichroism (Chapter I) and the rationale about how we design and prepare electronically tuned …
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Study of force discrimination on chiral molecules and particles by circular polarized light and metasurface enhanced field
… thesis aims to explore force discrimination on chiral particles and molecules, when experiencing an electromagnetic field. This thesis focuses especially on incident fields with handedness. These fields come from incident circular polarized light or from enhanced fields generated by a plasmonic …
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The application of physicochemical methods for the analysis of small and complex pharmaceutical drugs
… investigated. The methods were applied to small chiral molecules and further extended to analysis of complex glycoconjugate vaccines.
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Determining molecular chirality with femtosecond LASERs
More than 200 years since its first discovery Chirality remains one of the most challenging aspects of analytical chemistry. As chiral enantiomers share almost all physical properties they are only distinguishable through interaction with another chiral system, be it chiral molecules or circularly …
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Photoelectron circular dichroism of anionic chiral metal complexes and deprotonated molecules
… the light direction) of electrons detached from chiral molecules with left or right circular polarized light. In the past two decades PECD spectroscopy has manifested as a potential method for enantiomeric discrimination, with a chiral sensitivity that can surpass conventional methods, such as …
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Migration and separation in structured microfluidic systems
… and the requirement of a specifically designed chiral selector for chiral separation. 1) Typical biotechnological separation techniques like filters, chromatography, or gel electrophoresis have a fixed implemented separation criterion, e.g. defined by pore size, affinity of the steady phase, or …
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Synthesis of Novel Chiral Heterocyclic Compounds for Antibacterial Agents and Peptidomimetics
Small chiral molecules are very important building blocks in the synthesis of biologically active compounds. These building blocks include nitrogen and oxygen-containing heterocycles such as 2-oxazolidinones, 1,3-oxazinan-2-ones, 2-oxazolines, oxazines, morpholine and morpholinones. Because of …
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Ab initio Calculations of Optical Rotation
… to as circular birefringence, is inherent to all chiral molecules and occurs because such samples exhibit different refractive indices for left- and right- circularly polarized light. This thesis focuses on the theoretical prediction of this chiroptic property using CC and DFT quantum chemical …
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Structure-Property Relationship of the Two-Photon Circular Dichroism of Compounds with Axial and Helical Chirality
Back in 1894 Lord Kelvin coined the term "chiral" in order to refer to molecules whose mirror images were not superimposable with themselves. Over the years, research has demonstrated the important role that chiral molecules play in life, chemistry, and biology as well as their importance in the …
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Construction of Metal-Organic Cages with Bimetallic Motifs and Self-Assembly of a Molecular Knot
… synthesis of a purely topologically chiral molecules. The thesis concludes with a chapter detailing conclusions drawn from this body of results and future work which follows from it on the synthesis of even more topologically complex structures.
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Silica mesocellular foam and carbon nanofoam for fine chemical synthesis and separation
… the selective separation for large molecules, polymers, and proteins is of particular interest. To achieve quality separations, the stationary phase should exhibit pore diameters greater than 10 nm to facilitate the diffusion of large analytes throughout the stationary phase. In …
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New approaches for the synthesis of unusual amino acids
… in the synthesis of nitrogen-containing molecules including alkaloids, antibiotics and unnatural amino acids. We have recently investigated the use of this reaction for the rearrangement of chiral molecules. This has led to the development of a highly diastereoselective, ether-directed …
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Advanced Quantum Mechanical Simulations of Circular Dichroism Spectra
… cost. This problem is amplified when it comes to chiral molecules, whose stereochemical assignments and associated chiroptical properties can be incredibly sensitive to small changes in their three-dimensional structure, requiring highly accurate theoretical methods. On the other hand, due to the …
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The origin of remarkable chromatographic differences in novel azulenyl-1,5-diols and synthesis and use of phosphinine and phosphabarrelene ligands for asymmetric catalysis.
… characterization and analysis of novel chiral molecules advance many areas of synthetic organic chemistry, both industrially and academically. This work touches on three of the major methods for obtaining enantiomerically pure compounds. Based on the observation of a remarkably large …
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Enantioseparation using a counter-current bioreactor
… for manufacture of enantiopure chiral molecules was explored, using as a model reaction the isolation of L-amino butyric acid (L-ABA) from a DL-ABA racemate and the enantioselectivity of D-amino acid oxidase (DAAO). Bioconversion of D-ABA to ketobutyric acid (KBA) by DAAO, …
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Asymmetric hydrogenation catalysed by platinum and iridium
… metal catalysts which have been modified by chiral molecules has been studied. The aim of this thesis was (a) to gain a greater understanding of the kinetics of asymmetric hydrogenation of methyl pyruvate (MeCOCOOMe) to methyl lactate (MeCH(OH)COOMe) over cinchonidine modified EUROPT-1, (b) …
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Spiropyrans as color-generating mechanophores
Due to the size scale of the molecules they work with, chemists are normally limited to indirect means of inducing and controlling chemical reactions. Sometimes, the inherent reactivity and structure of the reactants and the properties of the products such as thermodynamic stability can be relied …
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Methodological advances for the measurement of the D-amino acids across the metazoa: From mollusks to man
The amino acids are a class of biomolecules which is obligatory to terrestrial life, alongside nucleic acids, fatty acids and monosaccharides. The amino acids, with the exception of glycine, are chiral molecules which exist as either L- or D-amino acids. Although identical with regard to physical …
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Novel methods and processes for the chiral resolution of fine chemicals
Chiral molecules occur in left- and right-handed configurations that can be considered asmirror images (enantiomers), and that, like hands, cannot be superimposed onto each other.Despite their similarity, the biological activity of enantiomers inside living organisms can becompletely different. …
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