Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"chimeric receptors"”.
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… has long been documented. T-cells expressing chimeric receptors are specifically redirected against such cells and have been proven to suppress autoimmune encephalomyelitis, the murine model of multiple sclerosis. We here demonstrate the ability of humanized chimeric receptors to suppress …
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Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of …
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β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor
… for β~arrestin dependent internalisation, chimeric receptors were created.
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Identification of a Domain on the Alpha 5 Integrin Subunit Implicated in Cell Spreading and Signaling
… four subdomains named domains I, II, III and IV. Chimeric receptors were prepared in which sequences on the alpha5 subunit were exchanged with the corresponding sequences on the alpha6 subunit, which is specific for laminin and does not bind via an RGD sequence. The mutated human alpha5 integrin …
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Reengineering Estrogen Receptor Hormone Specificity Through Coordinated Changes at Key Contact Sites Between Estrogen Receptor and Estradiol
… residues in its receptor. In the nuclear hormone receptors, mutational mapping studies, and more recently, X-ray structures, provide information on these key, specificity-defining contact sites. Based on this information, we have made a series of coordinated changes in the A-ring of estrogens (E) …
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Molecular basis of Fce receptor: IgE interactions
… receptor for IgE (a chain) - FceRI-a, chimeric receptors of FceRI-a and FcyRIIa, with FceRI-a point mutants, and their interaction with IgE.
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The emerging role of the a4(+)a4(-) interface as a determinant of functional signatures of a4ß2 nicotinic acetylcholine receptors
… ligand-gated ion channels (pLGIC), a4p2 receptors are activated by binding of agonist to sites located at the a4( + )/P2( -) interfaces. These interfaces are present in both stoichiometries they are unlikely to contain structural differences conferring specific properties to (a4~2)2a4 and …
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Glycoprotein hormone receptors in sea lamprey (Petromyzon marinus): Identification, characterization and implications for the evolution of the vertebrate hypothalamic-pituitary-gonadal/thyroid axes
… FSH, thyrotropin TSH) and glycoprotein hormone receptors GpH-R (LH-R, FSH-R and TSH-R respectively).</p><p>GpHs and GpH-Rs originate in a common ancestral ligand/receptor pair. Their duplications were followed by divergent evolution resulting in the emergence of a novel, pituitary/peripheral …