Global ETD Search
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Showing 1 to 2 of 2 for “"chimeric peptides"”.
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Peptide-mediated delivery of antisense oligonucleotides and chemotherapeutics across biological barriers
Many nucleic acids, peptides, and small molecules struggle to become clinically viable therapeutics as a result of poor delivery. Biological barriers such as the plasma membrane and the blood-brain barrier (BBB) contribute to this challenge as they can limit the passage of macromolecules. …
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Design and Characterization of Chimeric Probes Specific to K48-K63-linked Heterotypic Ubiquitin Chains
… this challenge, in this study we engineered a chimeric polypeptide probe by fusing ubiquitin-interacting motif(UIM) domains from two distinct ubiquitin-binding proteins and optimizing the linker that connects the UIMs. Our initial construct, RA20, exhibited selective recognition of heterotypic …