Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 381 for “"chimeric"”.
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DENVax live attenuated chimeric dengue vaccine
… attenuated virus vaccine, DNA vaccine, and a chimeric vaccine in the yellow fever virus vaccine backbone. Inviragen, Inc., a biotech company, in collaboration with the Center for Disease Control and Prevention (CDC), is developing a chimeric live attenuated virus vaccine that is currently in …
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Exogenous donor-derived hepatogenesis in chimeric hosts
… potential for generating donor-derived organs in chimeric hosts. In this dissertation, we begin with a comprehensive review of the literature (Chapter I) regarding histology and anatomy of liver, cardinal functions of the liver, followed by an overview of the current knowledge of embryonic liver …
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
Despite recent landmark advances in chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of human cancer, metastatic solid tumors remain an intractable challenge. Myeloid cells are actively recruited to the tumor microenvironment (TME), where tumor associated macrophages (TAMs) …
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In vitro diversification of chimeric human/chicken antibodies
… although presenting new challenges, I found that chimeric human/chicken antibodies could be engineered and expressed in this cell line and overcame many of the problems experienced with scFvs evolution. This approach was used to generate a combinatorial library for the screening of novel …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… has long been documented. T-cells expressing chimeric receptors are specifically redirected against such cells and have been proven to suppress autoimmune encephalomyelitis, the murine model of multiple sclerosis. We here demonstrate the ability of humanized chimeric receptors to suppress …
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Design characterisation and in planta expression of a chimeric xylanase
… hydrolysis of the biomass. Additionally, chimeric thermostable enzymes could be constructed from extremely thermophilic CAZyme domains, tailored to target specific biopolymers and perform directed modifications. However, while full-length CAZymes have been investigated, the extent of …
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Molecular assembly and function of Androglobin, a novel chimeric globin.
Androglobin (Adgb) is a multi-domain protein that contains a calpain-like and a circularly permuted globin-like domain. Adgb is the fifth mammalian globin to be discovered and is predominately expressed in the testes. Whilst Adgb is probably the least studied and understood globin member this …
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Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia
… T CELLS WITH CHIMERIC ANTIGEN RECEPTORS TO TARGET CD123</strong><strong>+ </strong><strong>LE</strong><strong>U</strong><strong>K</strong><strong>E</strong><strong>M</strong><strong>I</strong><strong>A</strong></h1> <p>Radhika Thokala, Ph.D*</p> <p>Advisory …
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Intracellular Traits of Chimeric tRNAlys3-ribozymes and their Inhibition of HIV
… the virions. We made constructs that express chimeric tRNALYs3- ribozymes from internal tRNA promoters. These chimeras were also adjoined downstream of a U6 promoter, resulting in a hybrid U6/tRNA expression cassette with extragenic U6 and intragenic tRNA promoters. Juxtaposition of the tRNA …
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Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells
… dendritic cells (iDC) were inoculated with a chimeric fusion protein vaccine containing the pancreatic β-cell auto-antigen proinsulin linked to a mucosal adjuvant the cholera toxin B subunit (CTB-INS). Proteomic analysis of vaccine inoculated DCs revealed strong up-regulation of the tryptophan …
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Development and characterisation of a novel chimeric antigen receptor against LGR5
… validation of novel 2nd generation LGR5scFv-Chimeric Antigen Receptor (CAR) NK and CD8 T cells using flow cytometry, functional in vitro assays and in vivo tumour xenograft models. While LGR5scFv-CAR NK92 cells exhibited high specificity, they had poor efficacy in vitro and failed to survive …
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Synthesis of Non-Steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (Protacs)
To make the PROTAC design more useful, a small molecule E3 ligase peptide mimic is desirable. The HIF-1alpha E3 ligase destruction sequence utilized in the PROTAC design requires a hydroxylated proline residue for recognition by the VCB E3 ligase. The synthesis of a tetrahydrofuran-based …
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Characterization of a recombinant chimeric yellow fever 17D vaccine - dengue-4 virus
… αβγ receptor deficient (AG129) mice the chimeric YFV 17D/DENV-4 prME virus was more virulent than either YFV-17D and DENV-4 parental viruses. It is hypothesized that the process of chimerization results in reduced genetic diversity indices of viruses, which may be linked attenuation of …
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Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma
<p>Chimeric antigen receptor (CAR) T cell therapy for glioblastoma remains challenging due to insufficient CAR T cell abundance and antigen-negative tumor cells evading targeting. Unfortunately, most preclinical studies evaluating CAR T cells in glioblastoma use tumors expressing a single antigen, …
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Engineering of next-generation chimeric antigen receptors based on alternative binding domains
Exogenous expression of chimeric antigen receptors (CARs) on T lymphocytes (CAR-T) and NK cells (CAR-NK) has allowed the design of effective therapies against lymphoproliferative diseases and has recently achieved success against solid tumors. Given their success, several researchers set out to …
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Genetic Stability of a Genetically-Engineered Chimeric Porcine Circovirus (PCV) Vaccine, PCV1-2
… backbone of the non-pathogenic PCV1. This chimeric PCV vaccine, called PCV1-2, was shown to induce protective immunity against PCV2 infection in pigs. The vaccine is currently on the market in a killed form. In order to develop a live version of the vaccine, the genetic stability of the …
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The rational structure-based design of a protein nanoparticle presenting a chimeric MenB antigen
… ferritin nanoparticle system displaying a chimeric protein antigen to stimulate broad and efficacious immunogenicity against MenB.;This chimeric antigen, incorporating epitopes from the NadA3 and PorA MenB antigens seeks to confer broader MenB strain coverage, while its incorporation into a …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
The main aim of this dissertation was to display novel immunological ligands, Thrombomodulin (TM) and CD47, on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory reactions associated with an immediate blood-mediated inflammatory response (IBMIR). In chapter 3, …
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Design, synthesis, and exploration of a chimeric antioxidant and new crosslinkers for molecular imprinting
… to determination of absolute configuration. A chimeric antioxidant composed of vitamin E and carnosine (VECAR) was designed and synthesized to improve drug delivery. VECAR was fabricated based on the lipophilicity and hydrophilicity of its individual components and is expected to have increased …
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