Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 113 for “"chimeras"”.
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Across the great divide : chimeras and species boundaries
… always been fascinated by borderline creatures. Chimeras, hybrids of multiple animals-and sometimes humans-appear repeatedly in mythology across cultures from ancient times to the present. Since the early 1980s, scientists have been creating cross-species chimeras, first combining mouse species …
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Of Cyborgs and Chimeras: Our Future With Emerging Technologies
This dissertation is an interdisciplinary exploration of the sociological, ethical, and philosophical implications of emerging technologies, with a special focus on biomedical engineering, more specifically neuro-interventions. I explore various technologies from algorithms, AI, and …
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Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras
… restriction sites. Of the constructs tested, chimeras containing EIII from Koutango virus (KOUV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV), and Bagaza virus (BAGV) were successfully recovered. Characterization of the chimeras in vitro and in vivo revealed …
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Chimeras and Jagunços: Positivist Discourse in Euclides da Cunha's Os Sertões
The present study elucidates the discursive practice of positivism, as particularly manifested in late nineteenth-century Brazil. Founded in 1889, the Republic of the United States of Brazil was constructed as a positivist state by republican idealists and pragmatic oligarchs; the political …
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Induced Degradation of G-Protein-Coupled Receptors Through Proteolysis Targeting Chimeras
… TPD methods include proteolysis targeting chimeras (PROTACs), which are heterobifunctional molecules where one end has a ligand for the protein-of-interest (POI), and the other end has an E3 ligase recruiting ligand. PROTACs take advantage of the ubiquitin-proteasome system (UPS) by forcing …
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Achieving Cell-Specific Delivery of Multiple Oligonucleotide Therapeutics with Aptamer Chimeras
… of the protein enable it to deliver aptamer chimeras from the cell surface to the nucleus. Therefore the nucleolin aptamer has unique access to the nuclei of cancer cells, and can deliver therapeutic oligonucleotide cargoes through nucleolin binding.</p><p>The nucleolin aptamer delivered …
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Creation and analysis of chimeras of spinach and tobacco Rubisco activase
Ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco: EC 4.1.1.39) catalyzes the initial step in photosynthesis, by combining CO$\sb2$ with ribulose bisphosphate to form two molecules of PGA. Rubisco activase is a protein which regulates the activity of Rubisco in vivo and hydrolyzes ATP. …
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Cellular Determinants Of AURKA Degradation By Small Molecule Proteolysis-Targeting Chimeras
… years the development of proteolysis-targeting chimeras (PROTACs) has enhanced the field of ubiquitin signalling through advancing therapeutic targeted protein degradation (TPD) strategies and generating tools to explore the ubiquitin landscape. However, the cellular factors that modulate PROTAC …
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Proteolysis targeting chimeras for the directed ubiquitination of the androgen receptor
Proteolysis targeting chimeras (PROTACs) are an emerging field of therapeutics and promising potential drug candidates. PROTACs consist of a target protein binder connected via a linker to an E3 ligase binder. PROTACs hijack the ubiquitin proteasome system to degrade the target protein in a …
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Generation And Statistical Modeling Of Active Protein Chimeras: A Sequence Based Approach
<p>Generation of active protein chimeras is a valuable tool to probe the functional space of proteins. Statistical modeling is the next logical step, allowing us to build a model of gene fragment replaceability between species. In this thesis I begin to develop the statistical tools that are needed …
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Lincoln's Dreams: An Analysis of the Sixteenth President's 'Night Terrors' and Other Chimeras
<p>Decades before Freud revealed his revolutionary dream theory, Americans became fascinated with the reported dreams of their greatest hero, Abraham Lincoln. Immediately following Lincoln’s assassination, accounts of his dreams and visions were recorded and made public by those who were close to …
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Novel Proteolysis Targeting Chimeras for the targeted degradation of the protein kinase CK2
… of CK2 activity. PROTACs (Proteolysis Targeting Chimeras) represent a novel therapeutic strategy that can induce target degradation through the 26S proteasome, offering potential advantages in potency, selectivity, and prolonged biological activity. The aim of this project was to develop novel …
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Directed Migration Achieved in Mammalian Cells via Ca2+ Signal Rewiring in Synthetic Protein Chimeras
Synthetic biology achieves control over cellular behavior by endogenous re-wiring. Ca2+ signals allow cells to regulate diverse processes such as migration, apoptosis, motility and exocytosis. In some receptors (e.g. VEGFR2), Ca2+ signals are generated upon ligand binding (e.g. VEGF-A). Here, …
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Proteolysis-targeting chimeras as a novel strategy for targeting epigenetic mechanisms in Plasmodium falciparum parasites
… proposed the use of Proteolysis-targeting chimeras (PROTACs) that can induce the degradation of a target protein via the cells ubiquitin-proteasome system rather than inhibiting it. Ideally, for PROTACs to be effective in malaria research, they should bind to essential proteins, such as …
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Human-Mouse Neural Crest Chimeras as a Novel Model for Human Melanocyte Biology in Development and Disease
… of xenogenic cells in human-mouse interspecies chimeras is an essential obstacle to overcome for the creation of disease models which allow the study of in vivo human cells. The two main barriers to donor cell survival are (1) having the capacity to respond appropriately to the xeno-environment …
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Pig tales, human chimeras and man-made public health hazards : an ethical analysis of xenotransplant benefits and risks
Xenotransplantatie wordt voorgesteld als een mogelijke oplossing voor het orgaantekort, alsook voor andere aandoeningen waarvoor momenteel geen of weinig behandelingen bestaan, zoals bepaalde neurologische ziektes en diabetes Type 1.De opzet van dit doctoraat was bij te dragen aan het ruime debat …
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Chorus for chimeras: a series of etchings towards the development of a personal iconography incorporating symbols, mythologies and ritual
Aspects of mythologies, their associated rituals and shamanism, are the subjects of this thesis. In a portfolio of twenty-one etchings, I have modified and recontextualised images from a variety of sources as a means to developing a personal iconography. Ritual and the creation of mythologies offer …
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Investigating the role of the West Nile virus and Koutango virus envelope protein in virulence phenotypes using structural protein chimeras
… To test this hypothesis, two additional chimeras (WNV/KOUV-prME and WNV/KOUV-E) and three WNV/KOUV-EIII mutants were generated to identify critical determinants of the attenuation. Following a series of biophysical, in vitro and in vivo assessments, it was determined that the attenuation …
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The Design, Synthesis and in vitro Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Degradation of Protein Arginine Methyltransferase 1
Protein arginine methyltransferase 1 (PRMT1) is a protein responsible for the asymmetric dimethylation of arginine. PRMT1 is upregulated in a wide range of cancers and the reduction of PRMT1 activity reduces cell proliferation and tumour growth in cell and animal models of cancer. A reduction in …
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The Use of Tissue Culture to Separate Apple (Malus Sp.) Chimeras Into Their Constituent Genotype(s) and to Induce Anthocyanin Production
To assess somaclonal variation, 'Gala', 'Royal Gala' and 'Jonagold' trees obtained via axillary and adventitious bud formation were compared ex vitro to conventionally grafted trees. In general, tissue culture-derived trees were relatively erect and their branch angles were relatively narrower in …
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