Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"childhood ALL"”.
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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… and somatic variations that are associated with childhood ALL, improving our understanding of the genetic basis of childhood acute lymphoblastic leukemia (ALL). Recent genome-wide association studies (GWAS) have identified germline genetic variations of ARID5B and, more recently, IGF2BP1 that are …
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Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most …
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The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)
Relapsed ALL remams one of the most common causes of death from disease in children. Broad-range drug resistance is often associated with relapse, although its underlying molecular mechanisms remained poorly understood. The aim of this thesis was to establish an in vivo model using the non-obese …
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Using Deep Learning to predict the mortality of Leukemia patients
… applied towards the prediction of mortality in childhood Acute Lymphoblastic Leukemia (ALL) patients. This is because individual children differ in the sensitivity of their leukemic cells and in their response to treatment-related toxicity. Currently, mortality prediction for childhood ALL is …
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Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis
… in the Vegfa promoter has been deleted at both alleles, thereby inhibiting HIF-binding and subsequent activation of Vegfa expression following hypoxia. We show that hypoxic regulation of Vegfa expression within the haematopoietic system affects haematopoietic differentiation and numbers of HSCs …
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Forecasting the Essential Chemotherapy Needed for Treatment of Children with Acute Lymphoblastic Leukemia in Low- and Middle-Income Countries
<p>Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with contemporary therapy resulting in a 90% survival in high-income countries (HIC). However, an estimated 89% of the world’s children live in low- and middle-income countries (LMIC) where survival is much lower. Lack of …
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Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia
… was identified<br/>as a novel and prognositically important acquired chromosomal abnormality in<br/>childhood acute lymphoblastic leukaemia (ALL). It is defined by multiple copies<br/>of the RUNX1 gene, as seen by fluorescence in situ hybridisation (FISH), localised<br/>to a single abnormal …
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Trisomies in Hematologic Malignancies
… ? gains of multiple chromosomes ? in childhood acute lymphoblastic leukemia (ALL). In the first two articles, AML and MDS cases with +8 as the seemingly sole abnormality were studied with fluorescence in situ hybridization (FISH) analysis and high-resolution genome-wide array-based …
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Development of animal models in pediatric cancer
… - the most common form of solid tumors in childhood cancer and leukemia- the most prevalent form of pediatric cancer. The thesis consists of two sections- Section1 includes testing and validating the therapeutic efficacies of novel compounds in preclinical models of neuroblastoma and …
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Hereditary and inborn etiology of pediatric cancer
The etiology of childhood cancer remains largely elusive. In rare cases, genetic mutations and environmental exposures such as radiation are known causes. For the vast majority of childhood cancer patients, there is no known cause for their disease. With an increasing number of childhood cancer …
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Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia
… the ETV6/RUNX1 fusion gene, present in 25% of childhood acute lymphoblastic leukemia. This fusion gene is important for leukemia development but is not sufficient for leukemia to arise. Hence, the additional genetic changes present in leukemic ETV6/RUNX1-positive cells give important clues …
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Sleep, Fatigue and Caregiver Burden in Parents of Children with Acute Lymphoblastic Leukemia (ALL)
… diagnosed with acute lymphoblastic leukemia (ALL) and receiving steroid therapy experience altered sleep patterns, fatigue, irritability, and other behavioral changes. As a consequence, parents may experience altered sleep, fatigue, and increased caregiver burden. If so, the differences seen …
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Identification of glucocorticoid-regulated genes and inferring their network focused on the glucocorticoid receptor in childhood leukaemia, based on microarray data and pathway databases
Acute lymphoblastic leukaemia (ALL) has the highest mortality rate in childhood cancer. Glucocorticoids (GCs) have been used as chemotherapeutic drugs for children with ALL for more than 50 years. GCs induce apoptosis in lymphoid cells. However, little is known about the molecular mechanism of …