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Showing 1 to 20 of 24 for “"chikungunya virus"”.
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A Role for Interferon Stimulated Gene-15 (ISG15) During Chikungunya Virus Infection
… for Interferon Stimulated Gene-15: ISG15) During Chikungunya Virus Infection</p><p>By</p><p>Scott William Werneke</p><p>Doctor of Philosophy in Biology and Biomedical Science</p><p>(Immunology)</p><p>Washington University in St. Louis, 2013</p><p>Professor Deborah J. Lenschow, …
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Translational Frontiers for Chikungunya Virus: New World Epidemic, New Strains, New Therapeutic Targets
Chikungunya virus (CHIKV) infection results in chikungunya fever (CHIKF), marked by sudden onset of high fever, rash, and debilitating polyarthritis and polyarthralgia, which can last for months to years. Despite the severe morbidity and impact on disability adjusted life-years, an FDA-approved …
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Development of Rapid Lateral-flow Immunochromatographic Test for the Diagnosis of Chikungunya Virus Infection
BACKGROUND/AIMS: Chikungunya (CHIK) virus is a mosquito-transmitted Alphavirus belonging to family Togaviridae that causes a number of outbreaks in Africa, India, and Southeast Asia with high morbidity. The major clinical symptoms resulting from CHIK virus infection are high fever, arthralgia, …
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Evaluation of Chikungunya Virus Infectious Events in Aedes Albopictus LR and Aedes Aegypti WE Mosquito Vectors
… on a vertebrate, the interactions between the viruses and the mosquito vector that facilitate successful infection and transmission are still not fully understood. Chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes albopictus and Aedes aegypti mosquitoes in tropical areas of …
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Characterization of the role of the innate immune system in the pathogenesis of chikungunya virus in mice
Chikungunya virus (CHIKV) is an alphavirus which causes a febrile illness in people that can induce a persistent and recurrent arthralgia. Recent outbreaks of CHIKV in tropical regions have caused millions of people debilitating illness. With no specific vaccine or anti-viral treatment, the …
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Adaptation of Chikungunya virus to Aedes albopictus mosquitoes: The role of mutations in the E1 AND E2 glycoproteins
Chikungunya virus (CHIKV) is a positive sense single-stranded RNA virus in the family Togaviridae that between 2005 and 2007 caused its largest outbreak/epidemic in documented history, affecting parts of Africa, the Indian Ocean islands, India, and Europe. An unusual feature of this epidemic was …
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The Expression of Chikungunya Virus Envelope 2 Glycoprotein Variants in Nicotiana benthamiana for the Development of a Diagnostic Reagent
Chikungunya fever is a non-fatal but highly debilitating disease that affects primates, birds and humans. The causative agent is the chikungunya virus (CHIKV), an arbovirus of the Alphavirus genus. CHIKV is responsible for the largest epidemic recorded for an Alphavirus, infecting an estimated 1.4 …
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Experimental and computational study of the mechanics of chikungunya
… from microorganisms like human immunodeficiency virus (HIV), influenza virus, Ebola virus, Zika virus, dengue virus, and malaria have infected millions of people in Africa. In Africa, viruses with a viral envelope, i.e. enveloped viruses, like HIV and influenza, cause thousands of deaths each …
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Rôle des moustiques Culicidae, de leurs communautés microbiennes et des réservoirs vertébrés, dans la transmission des arbovirus à Madagascar
… was available about the local dynamics of the virus transmission and identity of the vector species and vertebrates réservoirs involved. Madagascar island was chosen for its high endemic biodiversity, contrasting climatic conditions and drastic changes in habitats due to an increase anthropic …
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Production and Testing of a Novel Live-Attenuated Chikungunya Vaccine
… and testing of a novel live-attenuated chikungunya virus (CHIKV) vaccine. To this end, multiple strategies were adapted from the IRES-based vaccine strategy first employed with VEEV vaccine strain, TC-83. The first strategy, CHIKV/IRESv1, was highly stable during cell culture passages in …
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The spread of Nipah and chikungunya viruses: implications for control
… a substantial burden on public health. Nipah and chikungunya have been identified as two emerging viruses that pose a significant threat with pandemic potential. This has led to considerable investment in the development of vaccines against the two pathogens, especially by the Coalition for …
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The Development of New Tools to Investigate Alphavirus Replication Kinetics
Members of the alphavirus genus pose a serious or potential threat to public health in many areas of the world. Nearly all alphaviruses are maintained in nature by transmission cycles that involve alternating replication in a susceptible vertebrate and invertebrate host. The maintenance of this …
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Natural Product Discovery from a Streamline Environment-to-Bioassay Pipeline
… of glucosamine derivatives with activity against Chikungunya virus. Ongoing work aims to elucidate their mechanism of action and the role of S. ureilytica M01 in viral transmission. Collectively, this dissertation advances microbial NP discovery by innovating the front end of discovery workflows, …
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γδ T CELLS MEDIATE PROTECTIVE IMMUNE RESPONSES INDUCED BY EILV/CHIKV, A CHIMERA VACCINE CANDIDATE, AGAINST CHIKUNGUNYA INFECTION
Chikungunya virus (CHIKV) is a re-emerging virus that causes acute chikungunya fever, often accompanied by severe and persistent arthralgia, known as chronic CHIKV infection (CHIKD). Development of safe and effective vaccines against CHIKV infection and disease remains a high priority. Eilat virus, …
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Intersecting Threats: Exploring Obesity's Impact on Viral Pathogenesis and Transmission
… to aggravate disease outcomes of respiratory viruses like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mosquito-borne viruses like West Nile Virus (WNV), chikungunya virus (CHIKV) and Mayaro virus (MAYV) and reduce the vaccine efficacy for influenza and SARS-CoV-2. Obesity …
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Modulation of Alphaviruses by Small RNAs
… public health. Maintenance of mosquito-borne viruses in nature requires a biological transmission cycle that involves alternating virus replication in a susceptible vertebrate and mosquito host. Although infection of the vertebrate host is acute and often associated with disease, continual …
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Evaluation of arthropod-borne virus recombination potential and phenotype: In vitro and in vivo analysis of flavivirus and alphavirus model systems
… whereby positive sense single stranded RNA viruses exchange segments of genetic information. Recent phylogenetic analyses of naturally occurring recombinant flaviviruses have raised concerns regarding the potential for the emergence of virulent recombinants either post-vaccination or …
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Usutu Virus: An Emerging Arbovirus Threat
Mosquito-borne viruses, such as dengue virus (DENV), Zika virus (ZIKV), chikungunya virus (CHIKV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), and West Nile virus (WNV) are major threats to global public health resulting in millions of infections and hundreds of thousands of deaths …
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Effective Strategies for Preventing and Mitigating Emerging Viruses
… of pandemic proportion, with zoonotic RNA viruses such as chikungunya virus (CHIKV) and SARS-CoV-2 posing significant threats to global health. Several environmental and evolutionary factors have fueled the emergence and spread of infection, creating a constant arms race against emerging …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
… of research that warrant further study. RNA viruses have since been at the forefront for pandemic and prevention preparedness due to their increased potential to cause future outbreaks. SARS-CoV-2 and Venezuelan equine encephalitis virus (VEEV) are both zoonotic positive-sense single-stranded …
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