Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"chemotherapy-induced peripheral neuropathy"”.
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Kratom Alkaloid Mitragynine: Therapeutic Role and Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
… Of all chronic neuropathic pain conditions, chemotherapy-induced peripheral neuropathy (CIPN) persists as a monumental public health crisis, as it is the most common comorbidity among those receiving chemotherapy for cancer treatment. CIPN is unique compared to other forms of neuropathic pain …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and debilitating side effect of cancer treatment, often persisting for months after therapy cessation and profoundly impairing quality of life. Among chemotherapeutic agents, paclitaxel (PTX) stands out for its broad clinical use …
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Effects Of Chemotherapy-Induced-Peripheral-Neuropathy On Spatiotemporal Gait Parameters And Fall Risk In Cancer Patients After The Completion Of Chemotherapy Drug Treatment
… </strong>Cancer patients undergoing chemotherapy often experience chemotherapy-induced-peripheral-neuropathy, which reportedly causes gait disturbances that may increase their risk for falls. Falls are a significant event because they have been linked to serious injuries and …
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Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
Peripheral neuropathies, as the result of nerve damage, are characterized by pain, numbness, and tingling in the extremities and slow nerve conduction. Chemotherapy-induced peripheral neuropathy is a major dose-limiting side effect of many other commonly used chemotherapeutic agents, including …
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Multiple Myeloma and Its Treatment Alter Peripheral Nervous System Structure and Function
… MYELOMA AND ITS TREATMENT ALTER PERIPHERAL NERVOUS SYSTEM STRUCTURE AND FUNCTION </strong></p> <p>Alyssa Katarina Kosturakis, BA</p> <p>Supervisory Professor: Patrick M. Dougherty, PhD</p> <p>Peripheral neuropathy is among the most deleterious side effects of frontline …
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THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of cytotoxic chemotherapy drugs. It has been reported that >60% of patients receiving chemotherapy suffer from this debilitating condition, which manifests itself in a polyneuropathy of paresthesia, hyperalgesia, …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
… malignancies, alone or in combination with other chemotherapy drugs. Like other chemotherapeutic agents, bortezomib treatment is frequently accompanied by chemotherapy-induced peripheral neuropathy (CIPN) that may be dose-limiting, adversely affecting quality of life and prognosis. The mechanisms …
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Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy
… lymphoid tissue in animal models of CNS and peripheral neuropathy. New evidence in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, suggests inflammation of the meninges and CP changes are crucial for disease induction, warranting further investigation. …
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PULMONARY DELIVERY OF RESVERATROL-LOADED NANOCOMPOSITE MICROPARTICLES TO TREAT LUNG CANCER
… cancer related death worldwide. Current cancer chemotherapy, involves the administration of cytotoxic drugs that kill all cells exhibiting a high rate of proliferation and regeneration, which is a characteristic of cancer cells, but also non-cancerous cells, such as hair follicles, bone marrow …
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Single and Combined Effects of Cannabinoids on Neuropathic Pain and Cognition
… mitigating neuropathic pain in a mouse model of chemotherapy-induced peripheral neuropathy. We additionally hypothesized that cannabidiol would not affect classic cannabinoid-agonist induced cognitive impairment in rodent models of learning and memory. Methodology. Neuropathic pain was induced by …
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Evaluating local skin heating as an early detection method for small-fiber neuropathy in women with breast cancer receiving paclitaxel (Taxol®)
… used to detect early signs of small-fiber neuropathy (local skin heating) could detect signs of small-fiber taxane-induced peripheral neuropathy (TIPN) in breast cancer survivors (BCS) during the first 6 weeks of Taxol®. Aims of the study were to compare the mean size of (1) axon reflexes …