Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"chemotherapy-induced"”.
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Hsp27 and Chemotherapy-Induced Autophagy As Biomarkers In Osteosarcoma
… for > 30 years. Despite aggressive multi-agent chemotherapy combined with surgical resection, a significant fraction of patients with localized disease relapse after optimal treatment. We evaluated the occurrence of cytoplasmic LC3B (light chain 3B)-positive puncta (a marker of autophagy) and …
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Lithium-Carbonate as a Protectant Against Chemotherapy-Induced Myelosuppression
… carbonate has been used as an adjunct to cancer chemotherapy to lessen the dose-limiting myelosuppressive effects of several anti-cancer drugs. Its mechanism is unknown, but several possible sites of action have been considered. Lithium causes a neutrophilia and may protect the bone marrow …
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Role of Manganese Superoxide Dismutase in Chemotherapy-induced Oxidative Stress
… (H₂O₂). Findings indicate that the rapamycin-induced cytostatic effect is characterized by increased levels of MnSOD and H₂O₂, and is necessary for the full growth inhibitory effect of rapamycin. Furthermore, over-expression of MnSOD elevated the level of H₂O₂ and increased sensitivity to …
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Effect of Scutellaria Baicalensis on Reduction of Radiation/chemotherapy induced Inflammation
Mucositis is a major complication associated with chemotherapy and radiation therapy for cancer. Mechanism of mucosal damage from both chemotherapy and radiotherapy are thought to be an inflammatory process. It has been known that many herbs have anti-inflammatory effect. This study was aimed to …
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Early Identification of Chemotherapy Induced Cardiotoxicity Using Structural and Functional Cardiovascular MRI
… left ventricular (LV) myocardium. This damage, chemotherapy induced cardiotoxicity, is difficult to detect noninvasively prior to the advancement of injury to an irreversible state with decrements in left ventricular ejection fraction (LVEF). As cancer survival rates increase, the occurrence of …
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Cellular mechanisms associated with chemotherapy induced ribosomal RNA disruption in ovarian cancer cells
… as a potential biomarker for patients receiving chemotherapy treatment. Given that most, if not all, chemotherapy treatments are associated with toxic side effects, the ability to differentiate early in treatment between patients whose tumours respond to chemotherapy versus patients whose tumours …
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Kratom Alkaloid Mitragynine: Therapeutic Role and Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
… Of all chronic neuropathic pain conditions, chemotherapy-induced peripheral neuropathy (CIPN) persists as a monumental public health crisis, as it is the most common comorbidity among those receiving chemotherapy for cancer treatment. CIPN is unique compared to other forms of neuropathic pain …
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Exercise mitigates chemotherapy-induced cognitive impairment in a mouse model of breast cancer.
Chemotherapy-induced cognitive impairment (CICI) has been a reoccurring side effect among breast cancer survivors. While many commonly used chemotherapeutic treatments do not cross the blood-brain-barrier they do suppress cell proliferation which has been associated with the suppression of …
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Stimulation of chemotherapy-induced immunity by targeting IL-6 in the tumor microenvironment
… anticancer immune responses generated by chemotherapy treatment. Specifically, we demonstrate that absence of IL-6 from tumor microenvironments leads to enhanced T-lymphocyte responses that culminate in the generation of long-term immunologic memory. These findings reveal one of the …
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MMP-7 nanosensors for urine-based detection of chemotherapy-induced senescence and pulmonary fibrosis
… therapy resistance. Therefore, detecting therapy-induced senescence is vital for monitoring treatment responses, identifying potential tumour progression, and tailoring patient-specific interventions with senotherapies. However, current in vivo senescence detection methods necessitate invasive …
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A quantitative analysis of chemotherapy-induced reactive oxidative species using genetically encoded sensors and generators
Recent advances in chemotherapeutic development have targeted vital mechanisms that ensure survival of cancer cells; these include the ability to evade immune surveillance, undergo metabolic adaptations and form a defense mechanism against oxidative stress. Cancer cells often possess higher …
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The Effect of Age and Sex on Chemotherapy-Induced Cachexia and Branched-Chain Amino Acid Metabolism
… while effective in combatting cancer, chemotherapy causes appetite loss, fatigue, altered metabolism and decreased physical activity, all contributing to muscle tissue breakdown and cachexia. Decades of research into investigating interventions to mitigate the effects of cachexia have …
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EGFR deficiency results in defective hair follicle cycling, resistance to chemotherapy-induced alopecia, and cutaneous inflammation
Treatment of cancer patients with epidermal growth factor receptor (EGFR) inhibitors causes perifollicular inflammation in the skin. Mouse models with EGFR deficiency predicted this folliculitis and revealed that abrogation of EGFR disrupts hair follicle cycling. Hair follicles transition between …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and debilitating side effect of cancer treatment, often persisting for months after therapy cessation and profoundly impairing quality of life. Among chemotherapeutic agents, paclitaxel (PTX) stands out for its broad clinical use …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… standard anthracycline–cyclophosphamide (AC) chemotherapy. While chemoresistance and metastasis are classically studied in isolation, mounting evidence suggests they are mechanistically intertwined. This thesis interrogates how AC shapes clonal evolution from primary tumors (PT) to metastatic …
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Effects Of Chemotherapy-Induced-Peripheral-Neuropathy On Spatiotemporal Gait Parameters And Fall Risk In Cancer Patients After The Completion Of Chemotherapy Drug Treatment
… </strong>Cancer patients undergoing chemotherapy often experience chemotherapy-induced-peripheral-neuropathy, which reportedly causes gait disturbances that may increase their risk for falls. Falls are a significant event because they have been linked to serious injuries and …
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