Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"chemotherapy sensitivity"”.
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The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
… of resistance. The factors that determine the sensitivity to TACE-doxorubicin are unknown. FOXO3 is a multifunctional transcription factor that plays a role in determining cell fate in response to stress. It frequently functions as a tumor suppressor but can also promote tumor pathogenesis. …
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ROLES OF 15-LIPOXYGENASE-2 (ALOX15B) IN SUPPRESSION OF TUMOR FORMATION, METASTASIS, AND SENSITIVITY TO CHEMOTHERAPY
… the tumor growth in vivo and increase the chemotherapy sensitivity in vitro. To investigate the biological role of 15-LOX-2 in vivo, we used mice with a deletion in the ALOX8 (15-LOX-2 orthologue in mice). Mice with a deletion in ALOX8 showed increased in the formation of mass like a tumor …
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Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia
… GATA1s, which has been shown to contribute to chemotherapy sensitivity. In contrast, in non-DS patients, overexpression of GATA1 has been correlated with poorer outcomes. In the first half of this work, we investigated the role that elevated GATA1 expression plays on the sensitivity of AMKL …
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… dysfunction. Fan1-deficient mice displayed hypersensitivity to ICL-inducing chemotherapeutic drugs and developed bone marrow failure following the treatment. We also demonstrated that formaldehyde and acetaldehyde are likely not the endogenous damaging agents that lead to KIN in the absence of …
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Analysis of prognostic and drug resistance markers in lung cancer
… the management of patients with lung cancer is chemotherapy resistance. In patients with NSCLC (80% of cases) initial response rates to cisplatin-based chemotherapy are modest at best. In the case of SCLC (20% of cases) the initial response rates to cisplatin-based chemotherapy are high. However …