Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"chemotherapy resistance"”.
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Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma
… prognostic markers and an attempt to overcome chemotherapy resistance in DLBCL. In the first study it was investigated whether immunohistochemical expression of CD40, previously associated with a favourable prognosis in DLBCL, had any prognostic impact after the addition of rituximab to …
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The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
Background:Chemotherapy resistance is a major obstacle in effective neoadjuvant treatment for locally advanced breast cancer. The ability to predict tumour response would allow chemotherapy administration to be directed towards only those patients who would benefit, thus maximising treatment …
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
Background:Neoadjuvant chemotherapy is a standard treatment for locally advanced breast cancer however chemoresistance can be a major obstacle in ER+ cancers. Using comparative proteomic approaches (antibody microarray/AbMA and 2D-PAGE with MALDI-TOF/TOF MS) to investigate a pilot series of breast …
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Prognostic and treatment predictive factors for radio- and chemotherapy resistance in breast cancer patients- a step towards personlized medicine
… result is the gene expression profile for “radioresistance” found in a patient cohort consisting of 100 lymph node negative patients operated with breast conservation surgery and either postoperative radiotherapy or not. The samples were analyzed with oligonucleotide array. A gene expression …
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Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer and urgently requires new therapies. Oncolytic viruses (OV) are a strong contender. OVs interact with immune components of the TME, which can be altered due to specific genetic mutations. The present study evaluates the impact of …
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Curcumin: A Multi-dimensional Approach to Pancreatic Cancer Targeting Cell Death and Exosomes
… rates are attributable in part to increasing resistance to cancer therapy. Cancer therapy resistance is caused by adaptations that favor survival within cancer cells and their environment, termed the tumor microenvironment. Intracellular adaptations include the overexpression of …
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Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer
… prognosis with high risk of late relapse and chemotherapy resistance. ZNF703 is the most frequently amplified gene and the putative driver oncogene within this locus, though mechanisms are poorly understood. To identify therapeutic vulnerabilities for ZNF703-amplified breast cancers, …
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The role of cancer stem cells in osteosarcoma
… and pose a therapeutic challenge due to enhanced chemotherapy resistance. This project had three aims: identifying whether OS cell lines contain subpopulations of putative CSC, identifying if CSC contribute to chemotherapeutic resistance and to elucidate paracrine cell signals controlling OS …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
… Therefore, we examined whether host-based RBV resistance develops through reduced cellular uptake, analogous to chemotherapy resistance in some cancers. We examined the effect of host-based RBV resistance on a model RNA virus, poliovirus, HCV replication in cultured hepatoma liver cells, and …
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Ube4B Levels Determine The Efficacy of Egfr and Stat5 Inhibitors In Treatment Resistant Neuroblastoma
… proliferation, and may provide a mechanism for chemotherapy resistance. UBE4B, an E3/E4 ubiquitin ligase, ubiquitinates the EGFR and promotes its lysosomal degradation ultimately attenuating EGFR signaling. Interestingly, the UBE4B gene lies in a chromosomal region (1p36) whose loss is …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… characteristics, providing them with therapeutic resistance and conferred tumor recurrence. Although metabolism plays a fundamental role in essentially every function of a cell, little is known about how the EMT programme involves in regulating cell’s metabolism contributes to the morphological …
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Development of a Dielectrophoresis-Based Cancer-Cell Analysis Tool
… within a tumor can respond differently to chemotherapy, resulting in resistance and recurrence. Addressing these differences while choosing a treatment modality could significantly improve chemotherapy outcomes. This work focuses on the development of a new modular device that leverages the …
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Mitochondria-Endoplasmic Reticulum Contact Sites: Regulation and Roles in Coordinating Cell Fate Decisions
… communication in cancer cell death and chemotherapy resistance. The first part investigates a previously uncharacterised role of a fatty aldehyde dehydrogenase (FALDH), which was identified in a proteomic screen performed in the McBride lab (McGill University, Canada), as a candidate …
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Nuclear Basic Fibroblast Growth Factor Regulation of Triple-Negative Breast Cancer Dormancy/Recurrence
<p>Chemotherapy remains the only available treatment for triple-negative (TN) breast cancer. Although some TN breast cancers respond initially to neoadjuvant chemotherapy, the majority of patients die within three years of treatment due to recurrent tumor growth. Developing ex vivo models for TN …
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Investigating the role of microRNAs and extracellular vesicles in cisplatin resistance in ovarian cancer
… of the contributors to this high mortality is resistance to cisplatin chemotherapy. Resistance to cisplatin is multifactorial involving various networks and tiers of regulation and is not completely understood yet. Among the regulatory molecules in the body, microRNAs have a prominent role in …
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Identification and Characterization of TONSL as an Immortalizing Oncogene
… DNA repair pathway, which may contribute to chemotherapy resistance. It is noteworthy that higher levels of TONSL protein in primary breast cancers, particularly in ER+ breast cancers, are associated with poor outcomes. Approximately 20% of breast cancers display recurring genomic …
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CELLULAR AND MOLECULAR MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
… the standard treatment of AML is still based on chemotherapy regimens (like "7+3") that have been in use for over 50 years. Approximately 20% of patients do not respond to standard chemotherapy, and even among those who initially respond, around 50% eventually relapse due to the development of …
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Investigating the function of the multidrug transporter ABCG2
… problematic in certain cancers, where it causes chemotherapy resistance. Recent structural information about ABCG2 from cryogenic electron microscopy has revealed conformational changes associated with transport. However, there has been little investigation of the driving forces behind the …
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