Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"chemotherapies"”.
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Nucleoside and oligonucleotide approaches towards potential HIV chemotherapies
The use of oligonucleotides directed against the mRNA of HIV promises site-specific inhibition of viral replication. In this work, the effect of aralkyl substituents on oligonucleotide duplex stability was studied using model oligonucleotide sequences in an attempt to improve targeting of …
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
… The case for the generation of new potential chemotherapies is compelling and urgent. Phosphodiesterase (PDE) enzymes degrade the secondary signalling molecule cyclic adenosine monophosphate (cAMP) to AMP by hydrolysis, thereby modulating and regulating the signal transduction to the effector …
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Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
The broad, long-term objective of this research is to develop drug leads for new antibiotics, antiparasitics, and cancer chemotherapeutics. Two main areas of focus are inhibition of the Methyl Erythritol Phosphate (MEP; non-mevalonate pathway) pathway in bacterial and parasitic human pathogens and …
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Investigating the effect of conventional chemotherapies, Cisplatin and Doxorubicin, in combination with a nuclear transport inhibitor, INI-43, on cerfical cancer cells
… maximal killing of cancer cells. Conventional chemotherapies used in the treatment of cancer include Cisplatin and Doxorubicin, both firstline drugs often used in combination with other treatments. Our laboratory has a focus on identifying novel therapeutic targets and found that Kpnβ1, a …
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Mechanisms of Sensitization to Chemotherapy in Non-Small Cell Lung Cancer
… non-small cell lung cancers to existing chemotherapies. Using a large panel of non-small cell lung cancers, response to common platinum-based doublet chemotherapy was tested, and compared in a statistical fashion to each chemotherapy as a single agent, to understand the breadth of …
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Rev7 is a novel regulator of chemotherapeutic response in drug-resistant lung cancer
… target and damage cellular DNA While genotoxic chemotherapies have proven to be highly effective agents for cancer therapy, it is well known that intrinsic and acquired cancer drug resistance is a problem that severely limits the successful elimination of a wide range of malignancies. This point …
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Cognitive, Academic, and Neuropsychological Effects of Treatment
… explored the effects of number of intrathecal chemotherapies and time off therapy on cognitive, achievement, and neuropsychological functioning of post treatment children with Acute Lymphocytic Leukemia (ALL). Participants consisted of sixteen sibling pairs between the ages of eight and …
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Evaluating CD44-EZRIN Interactions in Triple-Negative Breast Cancer: Tumourigenesis and Drug Resistance
… directional migration, and sensitivity to chemotherapies, as well as in vivo metastatic potential. Using co-immunoprecipitation assays and a split luciferase protein-protein interaction biosensor, we explored the effect of engineered amino acid substitutions in CD44 and Ezrin on their …
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A pathways-based approach identifying determinants of drug resistance in oesophageal adenocarcinoma
… limits the effectiveness of current chemotherapies, with less than 20% of patients experiencing complete pathological response, so the discovery of underlying resistance mechanisms and novel agents to target these pathways is crucial.<br/><br/>Materials and Methods: <br/>273 …
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The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer
… targeted HER2 drugs are ineffective. The use of chemotherapies in treating TNBC is an effective option instead. However, chemotherapies are not selective, thus they cause severe side effects such as cardiotoxicity, myelosuppression, alopecia and gastrointestinal problems. A peptide-drug conjugate …
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Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs
… prostate cancer (HRPC) to avoid this effect. Chemotherapies are currently the primary treatments for HRPC. Unfortunately, none of the available chemotherapies are curative. Among them, paclitaxel and docetaxel are two of the most effective drugs for HRPC. More importantly, docetaxel is the …
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DEVELOPMENT OF A NOVEL CLASS MULTIMODALITY NANOPARTICLE AND CYTOTOXIC CONJUGATE FOR CANCER THERAPY
… even after the treatment with these conventional chemotherapies leaving the damage of systemic toxicity which may lead to metastasis. Recent studies demonstrated nano-sized complexes has the potential to deliver chemotherapeutics via indirect tumor targeting towards leaky tumor vasculature via …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
… to PDAC’s cold immune environment. In addition, chemotherapies have limited efficacy as a monotherapy and can significantly impact patient quality of life in combination with other chemotherapies. Currently, radiation therapy (RT) is the best treatment option for PDAC, but dose escalation is …
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Identification and Development of Novel Compounds for the Treatment of Human Cancers
… has fallen short. Because general chemotherapies that target DNA replication have only a limited efficacy and significant non-target side-effects, a new paradigm for cancer drug development has been adopted. Using a molecular targeted approach, new gene and protein targets have been …
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STRUCTURE-ACTIVITY RELATIONSHIPS IN FUNCTIONALIZED PLATINUM-ACRIDINE ANTICANCER AGENTS
… cisplatin, the development of new platinum-based chemotherapies with improved activity and reduced toxicity has become a pressing goal. Many second- and third-generation derivatives of cisplatin have been successful in decreasing toxicity, enhancing delivery, and showing a broader spectrum of …
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Early Identification of Chemotherapy Induced Cardiotoxicity Using Structural and Functional Cardiovascular MRI
Anthracycline chemotherapies induce nonfocal cardiac injury to the left ventricular (LV) myocardium. This damage, chemotherapy induced cardiotoxicity, is difficult to detect noninvasively prior to the advancement of injury to an irreversible state with decrements in left ventricular ejection …
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Design and synthesis of small-molecule inhibitors as anti-malarial and anti-serpin agents
… is a great need for developing effective new chemotherapies. PAI-1 is a major component in the regulation of the plasminogen activation system, and the overexpression of this protein has been implicated in a number of conditions, such as thrombosis, atherosclerosis, and myocardial infarction. …
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Design and synthesis of novel P. fulciparum GDH inhibitors for use as potential antimalarial agents
… developing resistance to the currently available chemotherapies. This has led to a new impetus to look for new antimalarial drugs that have different modes of action to the ones that are currently available. This thesis contains the following areas of research: 1) The design and synthesis of …
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Investigations into the Metabolic Requirements for Lipoic Acid and Lipid Species During the Life Cycle of the Malarial Parasite Plasmodium Berghei
… transmission of the disease and to generate new chemotherapies to cure infections. This study focuses on two specific aspects in the field of lipid biology of Plasmodium parasites and their hosts. Lipoic acid is a short eight-carbon chain that serves a number of different functions with the cell. …
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An investigation into the molecular mechanisms induced by derivatives of natural products in oesophageal cancer
Current chemotherapies for oesophageal cancer display poor efficacy and tolerability, highlighting an unmet need for novel chemotherapeutic agents. Artemisinin derivatives, currently used to treat malaria, were recently shown to possess potent anticancer activity. This study investigated the …
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