Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"chemotherapeutic resistance"”.
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Is there an association between S1P signaling and the transcription factor Nrf2?
… development, overexpressed Nrf2 enhances the resistance of cancers to drugs, chemotherapy or radiotherapy. Sphingosine 1-phosphate is a biological lipid mediator that serves a pivotal function in physiological functions and pathophysiological conditions. Synthesized by sphingosine kinase, S1P …
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Cellular response to 11[beta]-dichloro, a novel aniline mustard-estradienone, in various prostate cancer cell lines
… chemotherapy, and early screening, acquired chemotherapeutic resistance has presented a challenge to treating more advanced forms of prostate cancer. To meet this challenge a new compound, 11[beta]-dichloro, was designed that would integrate lessons learned from previous studies with other …
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The Role of Inflammation and Nitric Oxide Synthase 2 in Triple-Negative Breast Cancer Metastasis
… indicates poor prognosis, poor survival, and chemotherapeutic resistance in triple-negative breast cancer (TNBC) patients. The tumor microenvironment (TME) comprises various cell types that play a role in tumor survival and invasion by providing soluble factors such as pro-inflammatory …
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DNA-damage-mediated remodeling of normal and tumor microenvironments modulates cell survival
Chemotherapeutic regimens involve the systemic administration of genotoxic compounds that induce cancer cell death via well-established DNA damage response signaling networks. While modern chemotherapeutic regimens can be curative, chemotherapeutic drug resistance remains a major clinical problem. …
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The Benefits and Detriments of Aneuploidy in Cancer
… another effect of aneuploidy: increased resistance to a wide variety of drugs. The slower proliferation of aneuploid cells is the predominant mechanism that protects them from some of the most common chemotherapeutics used today. When proliferation rate is equal between euploid and …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… the majority of patients will develop resistance to DNA-damaging chemotherapy and relapse. Recent studies indicate that RNA-binding proteins (RBPs) appear to play a particularly important role in cancer, and may contribute to chemoresistance, but the field is still at an early stage and …
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Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma
… implicated in the development, progression and chemotherapeutic resistance of different cancer types. Consequently, many studies have made attempts to identify and quantify the expression of various DNA repair genes and their products in different cancers. It is on a similar note that this …
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Rational enzyme-directed prodrug development : exploiting tumour hypoxia to target the bioactivation of cytotoxic prodrugs
… Hypoxia is an important cause of radioresistance and is a independent prognostic indicator for local recurrence, metastatic spread and overall survival. Evidence also implicates hypoxia in chemotherapeutic resistance and genetic instability, as well as the progression of and selection …
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IGPR-1 promotes colorectal cancer tumor cell survival and modifies the response of cancer cells to chemotherapeutics
… of patients due to innate and acquired resistance, underscoring a need for better diagnostic and therapeutic strategies for CRC. Immunoglobulin-containing and proline-rich receptor-1 (IGPR-1) is a novel cell adhesion molecule (CAM) that was recently identified in our laboratory. IGPR-1 …
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The role of cancer stem cells in osteosarcoma
… challenge due to enhanced chemotherapy resistance. This project had three aims: identifying whether OS cell lines contain subpopulations of putative CSC, identifying if CSC contribute to chemotherapeutic resistance and to elucidate paracrine cell signals controlling OS tumour growth. …
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Trim24 As An Oncogene In The Mammary Gland
… promote tumorigenic phenotypes, metastasis, and chemotherapeutic resistance. Moreover, new experimental tools offer the ability to address questions we were previously unable to assess. My project takes advantage of a new mouse model to understand the role of a proto-oncogenic, transcriptional …
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Structural and Functional Analysis of Substrate Recognition and Inhibition of the Multidrug Transporters MRP1 and MRP2
… is less than 50%. Overexpression of multidrug resistance protein 1 (MRP1), a plasma membrane ATP-binding cassette (ABC) transporter, is associated with high-risk neuroblastoma. While it is known that MRP1 transports multiple neuroblastoma chemotherapeutic agents out of the cell in a glutathione …