Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 579 for “"chemotherapeutic"”.
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Novel chemotherapeutic agents for oesophageal cancer
Chemotherapeutic agents such as cisplatin, doxorubicin and 5-fluorouracil are currently used in the treatment of a variety of cancers, including oesophageal cancer. Although these agents have been part of our therapeutic repertoire for many years, there are several side effects that have been …
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The chemotherapeutic potential of Boswellia carterii oleoresins
… anti-cancer activity and may be a potential chemotherapeutic source. However, research on one species; Boswellia carterii is comparatively limited. Given the chemical profile of Boswellia varies considerably across species, B. carterii may be an underexploited therapeutic source. Therefore, …
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Antioxidant pathways and human leukaemia chemotherapeutic sensitivity
… of cancers (including AML) and implicated in chemotherapeutic drug-resistance. HO-1 protects AML cells from induced apoptosis via its transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2). We show a role for HO-1 in regulating apoptosis in AML cells in response to ara-C and …
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Some potential chemotherapeutic agents derived from aralkyl ketones
Dissertation (Ph.D.)--University of Kansas, Pharmaceutical Chemistry, 1952.
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Apoptosis and porphyrin biosynthesis by a photodynamic chemotherapeutic
$\delta$-Aminolevulinic acid (ALA) causes transformed cells to accumulate protoporphyrin IX (Proto). Subsequent exposure to light in vitro causes intracellular Proto to initiate formation of singlet oxygen molecules, leading to self-destruction. This photo-activated destruction by ALA is enhanced …
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Responses of Nitrifying Bacteria to Aquaculture Chemotherapeutic Agents
As in any animal production industry, disease is inevitable; therefore, it is imperative that aquaculturists are able to effectively manage the disease and maintain their high production levels in an effort to bridge the gap between supply and demand in the seafood industry that has been caused in …
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“Priming” as a novel strategy to enhance chemotherapeutic efficacy
… to improve the efficacy of pre-existing chemotherapeutic agents. With cancer incidence increasing worldwide, there is a need to improve current treatments without exacerbating side effects and impairing patient quality of life. In this thesis, I show that acetate improves the …
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Pyrrolo [2-3-b] Pyridines of Potential Chemotherapeutic Value
The methods available for the synthesis of pyrrolopyridines and the biological activity of the pyrrolo [2,3-b] pyridines are reviewed briefly. The reasons for the synthesis of pyrrolo [2. 3- b] pyridines from a pyrrole precursor are discussed and the possible routes from the available starting …
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Cancer Cell Mechanics in Chemoresistance and Chemotherapeutic Drug Exposure
… aim of this study was to identify the effects of chemotherapeutic drug exposure on the mechanical properties and cytoskeletal composition of drug sensitive and drug resistant malignant melanoma cells. To achieve this, a combination of Multiple particle tracking microrheology (MPTM), quantitative …
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Targeted and stimuli-responsive polymers as chemotherapeutic delivery systems
Successful administration of chemotherapeutic agents for cancer treatment requires a balance between the efficacy and the safety of the drug. This often limits physicians to a very narrow therapeutic window. To avoid the harmful side-effects, chemotherapeutic agents may be administered at a …
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USE OF DNA APTAMERS FOR TARGETED DELIVERY OF CHEMOTHERAPEUTIC AGENTS
The development of safe and efficacious chemotherapeutics has been the goal of cancer researchers for decades. Many different methods have been used to pursue this goal ranging from small molecules that act targets to large biomolecules such as antibodies. Aptamers are a new class of biomolecules …
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Controlling the Stability of Colloidal Drug Aggregates for Chemotherapeutic Delivery
… aggregates on the in vivo pharmacokinetics of chemotherapeutics. Stable colloidal formulations showed increased plasma circulation half-lives compared to solubilized, monomeric formulations. Overall, we demonstrate methods to stabilize, study and utilize colloidal drug aggregates, turning a …
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Apoptosis induced by cancer chemotherapeutic drugs and its genetic suppression
… apoptotic cell death on treatment with chemotherapeutic agents in an IL-3 dependent cell line (FDCP-1) and three different EBV genome-positive Burkitt's lymphoma cell lines, the survival of EBV-BL cell lines expressing either exogenous bcl-2 or BHRF1 was examined. Suppression of …
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New Chemotherapeutic Approaches for the Treatment of Parasitic Protozoan Diseases
… objective of this research is to develop new chemotherapeutic approaches for the treatment of parasitic protozoan diseases. The work presented in this thesis focuses on the design, synthesis, and screening (in vitro and in vivo) of bisphosphonates as a novel class of anti-parasitic agents. The …
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ACETYL COA CARBOXYLASE 1 IN PROSTATE CANCER AS A CHEMOTHERAPEUTIC TARGET
… considered when attempting to inhibit ACC1 for chemotherapeutic purposes.
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The synthesis, structural characterization and biological evaluation of potential chemotherapeutic agents
… them potential targets at which to direct novel chemotherapeutic agents. The inhibitor N-benzoyl-L-Leu-Gly nitrile prepared in this laboratory was shown to possess significantly greater inhibitory potency on the liver fluke Fasciola hepatica cysteine cathepsin L like endoproteases over the known …
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Application of pharmaceutical technologies to improve the activity of cancer chemotherapeutic agents
… modality in cancer treatment. Conventional chemotherapeutic agents usually have limited efficacy. Furthermore, chemotherapeutic agent- and/or excipient-related toxicities comprise a serious problem that may, in many cases, deteriorate the patient’s quality of life. In this dissertation, …
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NATURAL OR BIO-INSPIRED POLYPHENOLS IN THE SYNTHESIS OF POTENTIAL CHEMOTHERAPEUTIC AGENTS
… compounds and to their evaluation as potential chemotherapeutic agents. More specifically, my research activity was devoted to lignans and neolignans, synthetized by chemical and/or enzimatic methodology. Hence, in particular, two polyphenol groups were studied, namely benzoxanthene lignans, …
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Personalized chemotherapeutic measurement of breast cancer cell response using photonic crystal microscopy
The student, Suhas Baddela, submitted this Thesis for approval on 2020-05-08 at 15:29.
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