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Showing 1 to 20 of 49 for “"chemosensitivity"”.
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Malignant Glioma: Chemosensitivity testing and Biomarkers
Chemosensitivity testing and molecular biomarkers are commonly used methods during the management of several types of malignant tumours in routine clinical practice. The present work attempts to transfer the use of these two concepts to the management of malignant gliomas. Chemosensitivity testing …
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HIF-1alpha role in oxygen-dependent radio- and chemosensitivity
… resazurin reduction. Oxygen-dependent radio- and chemosensitivity was evident in all wild type whereas it was reduced or abolished in HIF-1α (siRNA) knockdown cells. The effects of HIF-1α-modulating drugs (EDHB, CoCl2, deferoxamine to stabilise and R59949 to destabilise it) reflected both …
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CRISPR/Cas9-mediated ATG7 knockout results in enhanced osteosarcoma chemosensitivity
Due to the development of chemotherapy, the survival rates in Osteosarcoma (OS) have improved immensely in patients with the localised disease. Despite this, long-term survival rates for OS patients facing metastatic or recurrent disease remains unchanged. One of the main reasons for this is …
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Unstable Ventilatory Control During Sleep After High Spinal Cord Injury: The Contribution Of Chemosensitivity And Hypoventilation
… HIGH SPINAL CORD INJURY: THE CONTRIBUTION OF CHEMOSENSITIVITY AND HYPOVENTILATION</p> <p>by</p> <p>Amy T. Bascom</p> <p>May 2015</p> <p>Advisor: Dr. Harry G. Goshgarian</p> <p>Major: Anatomy and Cell Biology</p> <p>Degree: Doctor of Philosophy</p> <p>A high prevalence of sleep-disordered …
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PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY
… of RelA/p65 on Ser536 is also beneficial for chemosensitivity in cancer therapy. Literature reports that NF-kappaB activation contributes to chemoresistance by regulating oncogenic pathways and multi-drug resistance genes, but recent studies on senescence and chemotherapy have suggested that …
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A feasibility study of chemosensitivity testing in primary cultures from malignant gliomas, and analysis of drug resistance mechanisms
… of providing information about tumour chemosensitivity in vitro by culturing glioma tumour cells in a hospital setting and performing chemnosensitivity assays on them using five common chemotherapeutic agents i.e. Cisplatin, Carmustine, Paclitaxel, Temozolomide and Etoposide. It was …
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Using machine learning to understand the link between gene essentiality, gene expression and the chemosensitivity of cancer cells
The emergence of pharmacogenomics databases has presented unique opportunities to leverage machine learning in precision medicine, particularly in drug response prediction. In this thesis, an in-depth investigation is conducted on carefully curated and integrated breast cancer focused datasets from …
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Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
<p>Glioblastoma Multiforme (GBM) is an aggressive brain tumor, characterized by high cellular heterogeneity, is refractory to treatment and has dismal prognosis. These characteristics of GBM have suggested the presence of stem-like cells that have the ability to initiate and maintain tumors of a …
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Effects of survivin and survivin inhibition in canine models of lymphoma and osteosarcoma
… cell proliferation and increase apoptosis and chemosensitivity in canine OS and LSA cell lines. We further hypothesized that we would observe inhibition of survivin and reduced tumor growth in murine models of canine OS treated with EZN-3042, an inhibitor of survivin. We additionally …
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Characterising pathways driving aggressive biology and chemoresistance in triple negative breast cancers biology and chemoresistance in triple negative breast cancers
… druggable targets, whose efficacy in restoring chemosensitivity was assessed via a number of methods, including RNAi, CRISPR, and targeted inhibition. In all, the preliminary identification of a means to sensitise an otherwise highly aggressive cancer to chemotherapeutics, represents an …
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E2F1 induction following DNA damage and oncogene activation
… with oncogenic stress, contributes to increased chemosensitivity. Cells expressing the adenovirus early region 1A (E1A) oncogene have been used as a tool to identify cellular regulatory pathways that modulate chemosensitivity. E1A sensitises cells to the induction of apoptosis by diverse stimuli, …
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Expression profile of multidrug resistance genes and proteins in cancerous and stem cells
… with MDR related genotype and phenotype. The chemosensitivity of the isolated CD 133 population was investigated using chemosensitivity assay. Meanwhile, a serum deprivation method was established in this study to enrich and select CD 133+ CSCs in a glioma (GOS-3) cell line. As a secondary …
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Involvement of CD133+ stem cells in the chemoresistance of glioma
… drugs at various concentrations and their chemosensitivity was compared in SFM and SCM. The U87MG cells when treated with cisplatin were significantly (P<0.05) less chemosensitive in SFM than in SCM. However, the cell survii'al in the two culture conditions did not vary significantly …
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Molecular chaperones and telomerase expression profiles and inhibition: Clinical implications for Glioma
… than chemotherapy alone. This increase in chemosensitivity could be attributed to the downregulation of hTERT caused by inhibition of l-Isp90c&. The research has led to two novel findings; 1) The identification of hsp90a in glioma 2) Silencing hsp90a led to approximately 13-fold reduction …
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Synthesis of bespoke matrices to investigate a novel anti-tumour molecular target using affinity chromatography. The design, synthesis and evaluation of biotinylated biarylheterocycles used as novel affinity probes in the identification of anti-tumour molecular targets.
… one of the imidazole sidechains was developed. Chemosensitivity studies confirmed that the biotinylated compounds retained their activity showing IC50 = 6.25 ¿M in a susceptible cell line, compared with > 100 ¿M for an insensitive cell line. The biotinylated ligands were complexed to a …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… and Bortezomib, significant enhancement of chemosensitivity was observed when used in combination with inhibitors of lactate dehydrogenase (Gossypol) and pyruvate kinase dehydrogenase (Dichloroacetate). In contrast, depletion of glutamine from media had to be extensive in order to induce …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… and Bortezomib, significant enhancement of chemosensitivity was observed when used in combination with inhibitors of lactate dehydrogenase (Gossypol) and pyruvate kinase dehydrogenase (Dichloroacetate). In contrast, depletion of glutamine from media had to be extensive in order to induce …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
… of glucose metabolism might be a marker of chemosensitivity in gastric cancer.
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