Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"chemoresistant"”.
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A Screen For Peptides Targeting Chemoresistant Metastatic Triple-Negative Breast Cancer
… develop novel compounds that specifically target chemoresistant cancer metastases. It is based on the hypothesis that metastatic cancer cells express unique cell surface receptors that can be targeted. To test this hypothesis, we performed a combinatorial phage-displayed peptide library screen to …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
<p>Prostate cancer (PCa) is the second most diagnosed cancer in males. This disease disproportionately affects African American men, with a higher incidence and mortality compared to other ethnic/racial groups. An aging male population and the complexity of addressing the health disparities …
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NEW PREDICTIVE FACTORS IDENTIFIED BY MOLECULAR STUDY IN CHEMORESISTANT HUMAN AND CANINE MAMMARY CARCINOMA CELLS
Mammary disorders in dogs occur very frequently in non-neutered and older animals. The majority of these tumors are classified as malignant and the occurrence of metastases in lymph nodes and distant organs can reach 30% of all cases. Canine mammary tumors (CMTs) share similarities with women’s …
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Establishment and characterisation of chemoresistant osteosarcoma cell lines by single and multi-agent induced strategies
… cancer cells. In this study, clinically relevant chemoresistant osteosarcoma cell models were developed from the cell lines MG-63 and HOS-143B. One of the strategies used the current study includes a multiple drugs combination approach, where cisplatin, doxorubicin, and methotrexate are combined …
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The mechanism of ovarian cancer chemoresistance
… develop tumour recurrence and succumb to chemoresistant disease. Therefore, improved targeting therapies and chemosensitisation strategies are essential for reducing the mortality of this devastating malignancy. This thesis investigates roles of epithelial-mesenchymal transition (EMT), …
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Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
Cancer a global epidemic is a major cause of morbidity and mortality affecting populations in all nations and regions. Breast cancer (BC) is the second most common cancer in the world and the most fatal malignancy affecting women both in the developed and developing countries. Even with the …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… regimen that produced stable disease, mirroring chemoresistant residual disease in patients. High‐complexity lineage tracing was combined with single‐cell RNA‐seq to track clonal and transcriptional dynamics across PT, lung metastases, and CTCs. I further developed a high‐throughput workflow to …
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Nanomaterials and Block Copolymers for Overcoming Multidrug Resistance in Cancer
… Using the respectively known chemosensitive and chemoresistant pancreatic adenocarcinoma cell lines MiaPaCa-2 and PANC-1, an in vitro analysis of the synergistic effect using 5-fluorouracil in conjugation with Pluronic® F127 was performed. By monitoring cell viability and regulation of cell …
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Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis
… In addition, ovarian cancers often become chemoresistant and metastatic, and recur following initial chemotherapy.</p>
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INVESTIGATING EPIGENETIC MECHANISMS OF CHEMORESISTANCE IN OVARIAN CANCER: THE ROLE OF H3K27ME3
… mark in an independent clinical cohort of chemoresistant tumours, compared to chemosensitive ones. To explore the molecular mechanisms linking H3K27me3 loss to the onset of chemoresistance in EOC, we generated in vitro platinum-resistant cell line models by exposing the platinum-sensitive …
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Cancer Cell Mechanics in Chemoresistance and Chemotherapeutic Drug Exposure
… a malignant melanoma cell line (WM1158) and a chemoresistant malignant melanoma cell line (SK-MEL29). Malignant melanoma was the cell line of choice as it is one of the most prominent types of cancer known to develop chemoresistance. The aim of this study was to identify the effects of …
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Downregulation of Pax2 Suppresses Ovarian Cancer Cell Growth
… cell ovarian carcinomas, which are relatively chemoresistant compared to high grade serous ovarian carcinomas. Four ovarian cancer cell lines, RMUGL (mucinous), TOV21G (clear cell), MDAH-2774 (endometrioid) and IGROV1 (endometrioid), which express high-levels of PAX2, were used to study the …
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Isolation and characterisation of canine osteosarcoma cells to investigate mechanisms of chemoresistance
… the role of autophagy-related genes in chemoresistant properties of canine OSA cells. Results: Inclusion of a RhoKinase inhibitor and pre-coating cell culture plastic with FBS was determined as essential for OSA cell isolation by collagenase digest. Cells from canine OSA biopsies and …
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Improving cancer therapy strategies via cellular stress and immune modulation
… and immune-based therapies, metastatic and chemoresistant cancers continue to exhibit poor clinical outcomes. This dissertation investigates two distinct therapeutic strategies designed to overcome tumor resistance and improve therapeutic efficacy. The first component of this work focuses on …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
… majority of patients (> 85%) will develop fatal chemoresistant disease despite multiple lines of treatment. Recent studies investigating the tumour immune microenvironment have highlighted the prognostic significance of different tumour infiltrating lymphocyte (TIL) subsets and secreted immune …
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
… the combined data.Methods:Samples from chemoresistant and chemosensitive breast cancers were selected following anthracycline-taxane chemotherapy and 4 experiments were performed using ductal ER+ tumours. Differential protein expression was compared between chemoresistant and …
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DNA-damage-mediated remodeling of normal and tumor microenvironments modulates cell survival
… tumor microenvironments such as the thymus are chemoresistant and that DNA damage in thymic endothelial cells induces an acute secretory response that promotes lymphoma cell chemotherapeutic resistance. Mechanistically, DNA damage induces the rapid activation of a p38-dependent stress response …
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RNA-Seq Reveals Transcriptomic Program Associated with Stemness in Taxane Resistant Prostate Cancer
… cells selected for chemoresistance. In addition, chemoresistant cells formed robust stem cell prostaspheres compared to chemosensitive cells, and expressed other markers of cancer stem cells. Overall, these findings support the hypothesis that PCa chemoresistance is driven by cancer stem cells.</p>
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