Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"chemoradiation"”.
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Chemoradiation in advanced vulval carcinoma
… have been investigated, particularly chemoradiation, which has shown significant success in the management of anal carcinomas. Primary chemoradiation has been used, instead of primary radical surgery, to treat advanced vulval carcinomas at Groote Schuur Hospital (GSH) since1982. Aims: …
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Adjuvant Chemoradiation Therapy in Gallbladder Cancer
… malignancy. Indications for adjuvant chemoradiation therapy after surgical resection have not yet been determined. We aimed this study to elucidate the effectiveness of adjuvant chemoradiation therapy according to TNM stage for gallbladder cancer. Between March 2001 and March 2009, 100 …
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
<p>Radiation injury in the esophagus occurs with high frequency from the treatment of non-small cell lung cancer (NSCLC). Radiation esophagitis is an acute normal tissue toxicity that negatively affects treatment efficacy by limiting dose and potentially interrupting radiation therapy. Clinical …
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Quantitative Dwi As An Early Imaging Biomarker of The Response to Chemoradiation In Esophageal Cancer
… is tri-modality therapy (TMT), where neoadjuvant chemoradiation (nCRT) is followed by surgical resection. Histopathology of resected tumors reveals that pathological complete response (pCR) is achieved in 20-30% of patients through nCRT alone. Because of the high mortality and morbidity associated …
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Pre-surgical exercise intervention in prostate and rectal cancer survivors
… the second, a narrative review on pre-surgical chemoradiation treatment in rectal cancer (Chapters 3); and three experimental chapters (4 to 6) including: a feasibility and efficacy study on the effects of a pre-surgical exercise intervention in prostate cancer patients; a second feasibility and …
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A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital
… squamous carcinoma treated with split course chemoradiation as opposed to continuous chemoradiation at Groote Schuur Hospital. Demographics including age at diagnosis, gender and HIV status were reviewed. The stage at diagnosis, the acute treatment toxicities and all surgical procedures were …
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Enhancing Radiation Sensitivity In Non-Small Cell Lung Cancer
… tumors in the clinically relevant context of chemoradiation. I have found that ganetespib sensitized lung cancer cells to radiation through attenuating DNA damage repair through attenuating DNA damage repair and accentuating G2-M cell cycle arrest. However, when combined with chemoradiation …
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Novel tissue- and blood-based biomarkers in Barrett’s Esophagus and esophageal adenocarcinoma
… finding of central fibrosis in lymph nodes after chemoradiation in esophageal cancer patients. The aim was to investigate the prognostic value of the number of lymph nodes with central fibrosis in patients with ypTN0 staged disease. I confirmed that in addition to the response by the primary …
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Pretreatment Serum CYFRA 21-1 Level Correlates Significantly with Survival of Cervical Cancer Patients: A Multivariate Analysis of 506 Cases
… by radical hysterectomy or primary concurrent chemoradiation therapy. The pretreatment serum SCC-Ag and serum CYFRA 21-1 levels were measured in these patients. A multivariate analysis using Cox’s proportional hazard model was performed to evaluate the prognostic significance of pretreatment …
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Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC
… standard of care for HNSCC patients consists of chemoradiation often combined with targeted therapeutic agents. However, the five-year survival rate for patients that relapse is < 50%. Patients with recurrent or metastatic disease have a very poor prognosis and typical survive < 12 months due to …
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Automated Treatment Planning in High Dose-Rate Brachytherapy for Cervical Cancer
Standard care of cervical cancer is chemoradiation therapy followed by a boost to the cervix tumor site with High-dose-rate brachytherapy (HDRBT). HDRBT is a procedure that involves the insertion of radioactive sources into the tumorous area to ablate the cancer. Treatment planning for the …
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Investigation of metabolism in glioblastoma patient-derived xenografts using deuterium metabolic imaging
… also showed a differential metabolic response to chemoradiation, which was detectable before any anatomical changes were observed on conventional 1H magnetic resonance imaging (MRI). Targeting metabolism in the treatment of cancer has led to a number of promising novel metabolic inhibitors …
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Analyzing the Effect of Neoadjuvant Stereotactic Ablative Body Radiotherapy on Pancreatic Tumour Perfusion Using Computed Tomography Perfusion
… an acute increase in tumour perfusion. While chemoradiation is already the current standard of care for the non-resectable, locally advanced pancreatic cancer patients, conventional fractionation schemes typically deliver around 2-3 Gy per fraction. In contrast, treatment using higher doses in …
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Studies of Replication Repair Deficient Brain Tumorigenesis Using Mouse Modeling
… universal hypermutation, resistance to standard chemoradiation, and variable susceptibility to immune-based therapies. Despite their clinical relevance, representative immunocompetent models of recently defined RRD subgroups are lacking. These subgroups are identified by specific somatically …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… the same: maximal safe resection, concomitant chemoradiation (CRT) with temozolomide (TMZ), and adjuvant TMZ. Thus, there is an urgent need to develop more therapeutic interventions for GBM to improve the disease prognosis. Our research group at the University of Wolverhampton has been working …
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Quantitative Non-Contrast Perfusion Measurements Using Arterial Spin Labeled MRI: Evaluation of Therapy Response in Brain Tumors and Technical Advancements in Kidneys
… of ASL-measured baseline perfusion prior to chemoradiation therapy for survival stratification between different groups in GBM. In part two of this thesis, we extended the application of ASL into kidneys, aiming to establish ASL measured renal perfusion as a robust, accurate, and quantitative …
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Nuclear-Targeted Gold Nanoparticles Enhance The Effects of Radiation Therapy With and Without Liposomal Delivery
… resection, and clinical trials evaluating chemoradiation in locally advanced patients with unresectable disease have been largely disappointing. New and creative therapeutic approaches are needed to address the unment need for treatment options. The objective of this thesis is to advance …
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The overall survival and local control benefit of external beam radiation therapy for selected cancers
… modalities’ benefits. The incremental benefit of chemoradiation (CRT) over radiotherapy alone was also estimated. Pre-existing Australian radiotherapy demand models defining the incidence of each indication were adapted. TreeAge Pro 2008 software was utilized. A systematic review was performed to …
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Soluble factors and remodeling in a synthetic stem cell niche
… e.g., anemias, leukemias, and myelo-ablative chemoradiation treatments. However, the rarity of the cells and scarcity of appropriately matched donors (<25% in some demographics) has necessitated methods to expand and maintain HSC populations ex vivo. Development of expansion methods requires …
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