Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"chemoproteomics"”.
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Cytosolic sphingolipids and lysosome reactivation in neurodegenerative diseases
… contributing to mitochondrial dysfunction. A chemoproteomics approach has found several proteins that bind ceramides and glycolipids. Chapter 4 sought to confirm the interactions between ceramides/glycolipids and their binding proteins using molecular modelling and gene expression analysis.
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Investigation and application of substrate tolerant thioether forming enzymes
… To identify LanCL targets, I developed a chemoproteomics method to enrich proteins with LanCL-catalyzed glutathionylation. The initial proteomics data suggest that LanCL protein targets are not limited to kinases and LanCL-catalyzed glutathionylation may function as a general mechanism to …
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Proteomic Approaches For Profiling Cofactor-Dependent Proteins In Mycobacterium Tuberculosis
Tuberculosis is an infectious disease that currently affects a quarter of the world’s population. The rise of new antibacterial resistant strains makes the discovery and development of new antibiotics imperative. Chapter 1 provides a broad overview of PLP-dependent enzymes in Mycobacterium …