Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"chemoprevention"”.
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Chemoprevention in Kidney Cancer
Background: This thesis is a composition of three studies that explore the role of statins in kidney cancer. Furthermore, I evaluate the potential for different interpretations from the same data depending on the method of classifying medication use. Methods: The first study was a population-based …
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Chemoprevention of Familial Melanoma
<p>Bleaching agents 4-tertiary butyl phenol (4-TBP) and monobenzyl ether of hydroquinone (MBEH) have been known to cause occupational vitiligo This project answers whether agents 4-TBP and MBEH can be used for prophylactic treatment of familial melanoma by being specifically toxic to melanocytes …
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Spray Techniques And Lung Cancer Chemoprevention
Chemoprevention is a promising approach to decrease the incidence of lung cancer in current and former smokers. Directly delivering drugs to the lung could lead to a high concentration in the target organ with a lower dose compared to other means of administration. The primary advantages of aerosol …
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Cancer Chemoprevention by Vaccinium and Vitis Extracts
In summary, the present studies suggest that specific fractions of both Vaccinium and Vitis species possess considerable anticancer activity. The exact compounds responsible for these activities and their specific mechanisms of action warrant further investigation as potential cancer …
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STATISTICAL METHODS FOR ANALYSIS OF CANCER CHEMOPREVENTION EXPERIMENTS
<p>The experimental systems studied in this dissertation are designed to investigate the effect of diet on incidence rates of cancer. These investigations involve the chemical induction of tumors in experimental animals in order to test the chemopreventative effects of various substances. Both …
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Initiating mutations and chemoprevention in BRCA1 mutation carriers
… physical risks and psychosexual implications, or chemoprevention strategies that have little evidence to support their efficacy in this cohort. <br/><br/>There is a clinical need to establish whether BRCA1 deficient women acquire a significant mutational burden prior to cancer formation, as …
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Cancer Chemoprevention by Curcumin and Structurally Related Beta-Diketones
Curcumin is a beta-diketone constituent of the spice turmeric that possesses anticarcinogenic properties in several animal models. However, the effectiveness of curcumin to act as an inhibitor of mammary carcinogenesis needs further attention. The present studies were conducted in order to evaluate …
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The Cellular and Molecular Properties of Flavinoids in Prostate Cancer Chemoprevention
… that have emerged as candidate agents for chemoprevention in prostate cancer. Despite the large number of known flavonoids (over 9000), only a few have been studied in prostate cancer to date. The work presented in this thesis describes the identification of novel anti-proliferative …
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Role of Polyphenolic Compounds in Chemoprevention of Breast Cancer Stem Cells
… of a natural epigenetic modulator in chemoprevention by specifically targeting CSCs.
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Characterization, Interaction and Chemoprevention of Potent Constituents From Grape Cell Culture
… on human DNA topoisomerase II for cancer chemoprevention; (2) to characterize constituents in the most potent fractions; (3) to investigate interactions between bioactive polyphenols present in the most potent fractions; and finally (4) to assess cytotoxicity of the subfractions using both …
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Chemoprevention of Lung Carcinogenesis: Aerosol Administration and Deposition in the Mouse Lung
<p>INTRODUCTION Chemoprevention is the use of natural or synthetic agents to inhibit either the initial development or the further progression of early lesions. Chemoprevention of lung cancer aims to decrease lung cancer morbidity and mortality, especially for former smokers. Many synthetic and …
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Novel Cellular Targets of Aspirin in Chemoprevention studies on P53, G6PD and c-MYC
… lines to gain an insight into the mechanisms of chemoprevention by aspirin, and to more clearly establish the generality of the observations. The studies on c-Myc are novel, and few reports exist on aspirin’s ability to modulate c-Myc functions in the literature. Understanding these …
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Induction of Synthetic Lethality In Mutant Kras Cells For Non-Small Cell Lung Cancers Chemoprevention and Therapy
… cancer patients remains low. Thus, effective chemoprevention and treatment approaches are sorely needed. Mutations and activation of KRAS occur frequently in tobacco users and the early stage of development of non-small cell lung cancers (NSCLC). So they are thought to be the primary driver …
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Exploiting a novel organotypic model of SOX2-driven early squamous lung cancer to identify potential routes to chemoprevention
… clinical development for potential efficacy in chemoprevention. I combined this approach with targeted genetic ablation studies to identify/characterise targets that may be key to the progression of SOX2-driven squamous cell carcinomas. In particular I highlight an AKT isoform dependence in SQC …
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Targeting the intestinal stem cell niche through energy and metabolism signaling, for colorectal cancer chemoprevention using aspirin and metformin
… the combination of aspirin and metformin for the chemoprevention of obesity- driven CRC remains to be explored. Hence, this thesis aims to understand whether aspirin and metformin decrease overnutrition-driven stemness in CRC, while exploring their synergistic potential and mechanism. In CRC cell …
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Characterization of Cellular and Genomic Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells
… cell is the most relevant target for chemoprevention. We investigate herein the cellular and genomic effects of 1,25 dihydroxyvitamin D3 (the metabolically active form of vitamin D3) on the prostate progenitor/stem cell and discuss their implications for prostate cancer …
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Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues
… that nucleoside transporters may be potential chemoprevention targets involved in the antitumor promotion activity of <strong>DPM</strong>and analogues. Signaling pathways are pivotal in tumor promotion processes and were therefore tested for in the chemopreventive mechanism of …
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Genomic Drivers of Cutaneous Squamous Cell Carcinoma Development
… order to identify novel targets for molecular chemoprevention, we used isogenic human samples throughout cuSCC development and a UV-driven Hairless mouse model of cuSCC to identify genomic drivers of cuSCC by cross-species analysis. RNA-Seq identified 349 transcripts that were differentially …
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Genomic Characterization of Polyps In Familial Adenomatous Polyposis Patients and Identification of Candidate Chemopreventive Drugs
… that may serve as potential targets for chemoprevention drug development. From each patient, a blood and at least one polyp were sequenced with a total of 25 polyps analyzed. In some cases, normal mucosa samples were also sequenced. We characterized point mutations, insertions, deletions …
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