Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"chemokine receptors"”.
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Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning
… I applied deep mutational scanning to the human chemokine receptors CXCR4 and CCR5, which are well-studied co-receptors for HIV-1 infection. Libraries of both receptors containing nearly all ~7,000 single amino acid substitutions were selected in tissue culture for surface expression, binding to …
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Role of proteases and chemokine receptors in a murine model of chronic obstructive pulmonary disease
… in COPD grotendeels wordt georkestreerd door chemokines en hun respectievelijke receptoren. Bovendien is het mogelijk dat de pulmonale inflammatie wordt geïnitieerd en zelfs onderhouden door signalisatie via zogenaamde ‘pathogen recognition receptors’ (PRRs). Een verhoogde vrijstelling van …
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Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver
… T cells phenotype and role played by distinct chemokine receptors expressed on regulatory T cells as they are major player in controlling hepatic tolerance. At the same time, it would be crucial to explore the role of new subset of Th17/Tc17 effector lymphocytes characteristic and their …
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EFFECTOR T CELL HOMING TO THE SMALL INTESTINAL MUCOSA
… small intestinal mucosa focusing on the role of chemokine receptors in this process. Firstly, we aimed at determining chemokine receptors involved in the localization of CD4+ T cells to the small intestinal LP. We show that endogenous CD4+ lamina propria lymphocytes (LPLs) express a heterogeneous …
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Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa
… the frequency of polymorphisms and mutations in chemokine genes, chemokine receptors and chemokine receptor promoter region which ma y be associated with HIV-1 resistance and prolonged disease progression. Secondly, to determine if the chemokine receptors on CD4 T-cells are sufficiently expressed …
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Application of Genetically-Encoded Photoactivatable Crosslinkers to Map Ligand-Binding Sites on G Protein-Coupled Receptors
<p>G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce biological signals. Although GPCRs represent the largest class of targets for therapeutic agents, ligand-binding sites have been precisely defined for only a small percentage of the …
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The role of chemokines in the pathology of multiple sclerosis and other neuroinflammatory diseases
… to sites of CNS inflammation is dependent on the chemokine gradients they encounter and the chemokine receptors they express. Multiple sclerosis (MS), subacute sclerosing panencephalitis (SSPE) and coeliac disease (CD), with associated neurological complications, are neuroinflammatory diseases …
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Pharmacological insights into C-‐C motif chemokine receptor 5 mediated chemotaxis
… being well validated as a therapeutic target, no chemokine receptor antagonists to be used as therapeutic agents in inflammatory or metastatic disease have made it to market. This is in part due to receptor redundancy, but also a lack of understanding with regard to cytoplasmic signal transduction …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
… is regulated through the specific action of chemokines and chemokine receptors. However, the molecular mechanisms underlying these processes are unclear. Understanding the regulation of CD8⁺ T cell traffcking should reveal key mechanisms in T cell differentiation and protective immunity, and …
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Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of …
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Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
… is regulated by chemoattractants, including the chemokine family. Chemokines bind to cognate G protein-coupled receptors to induce cell migration and are upregulated in many chronic inflammatory diseases characterised by aberrant immune cell migration. While chemokines represent an attractive …
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Generation of a novel pan-cancer chemokine receptor-modified CAR-T cell therapy directed towards nfP2X7
… displayed minimal expression of co-inhibitory receptors. NfP2X7-targeting CAR-T cells effectively lysed tumour cell lines derived from a broad range of solid and haematological cancers including breast, prostate, ovarian, colorectal, skin, lung, neuroblastoma and B-cell lymphoma in vitro. …
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Pregnancy associated progenitor cells migrate, integrate and contribute to maternal hematopoietic compartments in the murine model
… the presence of major growth factor and chemokine receptors VEGFR1, c-Kit and CXCR4 on PAPCs during gestational and postpartum timepoints which may explain the migratory patterns of PAPCs to maternal tissues, injuries and neoplastic transformations. In addition, presence of VEGFR1+ CD34+ …
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Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
Peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and …
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BIOLOGICAL AND TRANSDUCTIONAL EFFECTS OF ALLOSTERIC ANTAGONISTS ON THE ACTIVITY OF CHEMOATTRACTANT RECEPTORS
There are two major chemokine receptors expressed on the surface of neutrophils, CXCR1 and CXCR2.It is thought that targeting both receptors may be necessary for optimal inhibition of PMN influx in several inflammation disorders such as post-ischemia reperfusion injury, pulmonary fibrosis, sepsis, …
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An investigation of how dendritic cell migration is modulated during Leishmania mexicana infection
… adaptive immunity. Consequently, manipulation of chemokines and chemokine receptors presents a potential mechanism by which parasites can evade protective host immunity. Therefore, the aim of this thesis was to investigate whether Leishmania mexicana can influence immune cell migration and …
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Chemokinrezeptorexpression auf T-Zellen in bronchoalveolärer Lavage und peripherem Blut bei Kindern mit chronischer Bronchitis und interstitiellen Lungenerkrankungen
… are recruited to sites of inflammation by chemokines. Accordingly, a number of chemokine receptors are differentially expressed on effector T cells. We hypothesized that selected T cells accumulate in inflammatory lung diseases involving different pulmonary compartments. To test this …
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Hyporesponsive synovial fluid T cells in rheumatoid Arthritis
… based on their differential expression of chemokine receptors CCR7 and CXCR6 (Bonzo), the recently described marker for replicative senescence KLRG1 and the effector/memory marker CD45RO revealed that the populations of T cells present in the SF from arthritis patients with anergic and …
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Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system
… organoids similar to previous studies. IL-15, a chemokine which is known to promote IEL proliferation and survival, can also affect IEL chemokinesis and chemotaxis. When IL-15 bindings was blocked, IEL movement was reduced. I also performed an analysis of IEL proteomic data for molecules …
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