Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"chemokine receptor"”.
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in …
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Configurationally restricted bis-tetraazamacrocyclic complexes: chemokine receptor antagonists
The chemokine receptor CXCR4 is a trans-membrane protein which has been implicated in many physiological and pathological processes including cancer, rheumatoid arthritis and most significantly HIV replication. CXCR4 plays a vital role in embryonic development but is not essential at the …
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Molecular Mechanisms Regulating Chemokine Receptor CXCR4 Signaling and Trafficking
<p>CXCR4 is a G protein-coupled receptor (GPCR) that binds to the chemokine, stromal cell-derived factor-1 (SDF-1alpha; a.k.a. CXCL12). The SDF-1alpha/CXCR4 signaling axis plays an essential role during embryogenesis in the development of the heart, brain and vasculature and in the adult mediating …
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Pharmacological insights into C-‐C motif chemokine receptor 5 mediated chemotaxis
… being well validated as a therapeutic target, no chemokine receptor antagonists to be used as therapeutic agents in inflammatory or metastatic disease have made it to market. This is in part due to receptor redundancy, but also a lack of understanding with regard to cytoplasmic signal transduction …
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis.
Expression of chemokines CXCL10 and CCL2 is elevated within inflammatory lesions in the central nervous system (CNS) of multiple sclerosis (MS) patients, particularly in astrocytes. These chemokines play a critical role in the recruitment of inflammatory cells into the CNS during inflammation. …
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CHARACTERIZATION OF HCMV-ENCODED CHEMOKINE RECEPTOR US28 TRANSDUCED MSU1.1 HUMAN FIBROBLAST CELLS
… (HCMV) encodes the G-protein coupled receptor US28. Using a mouse model system, US28 was previously found to be oncomodulatory, increasing proliferation, inducing anchorage independent growth and loss of contact inhibition. Similarly, in the human glioblastoma cell line U373, US28 …
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Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists
The chemokine receptor CCR5 has been implicated in the pathogenesis of cancers and AIDS. A series of novel piperidine derivatives were designed, synthesized, and evaluated as CCR5 antagonists. The ability of the new ligands to inhibit the increment of intracellular calcium level stimulated by …
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The role of chemokine receptor trafficking in regulating neutrophil migration to inflammatory sites
… attractant molecules, a major class of which is chemokines. Chemokines bind to G-protein coupled receptors (GPCRs) and initiate complex intracellular signalling cascades which ultimately result in directional neutrophil migration. Upon ligand binding, GPCRs can undergo multiple trafficking fates …
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The Chemokine Receptor CXCR7 Functions in Endocardial-Derived Cells to Regulate Cardiac Valve Remodeling
… common congenital heart diseases. CXCR7 is a chemokine receptor whose function in the heart is unknown. Unexpected cardiac phenotypes of Cxcr7 knockout mice prompted further investigation to elucidate its role during heart development. I speculated that CXCR7 functions during cardiac valve …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… indicates that elevated maternal levels of the chemokine interleukin- 8 (IL-8) during MIA contribute to the neurodevelopmental alterations underlying the disorder. The present experiments used an animal model of neurodevelopmental disorders to study the effects of MIA and chemokine receptor …
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The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… secrete immune mediators such as cytokines and chemokines. CC-chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family of seven transmembrane G protein coupled receptors. CCR5 is expressed in the immune system and is found in monocytes, leukoctyes, memory T cells, and immature …
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The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… secrete immune mediators such as cytokines and chemokines. CC-chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family of seven transmembrane G protein coupled receptors. CCR5 is expressed in the immune system and is found in monocytes, leukoctyes, memory T cells, and immature …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
… is regulated through the specific action of chemokines and chemokine receptors. However, the molecular mechanisms underlying these processes are unclear. Understanding the regulation of CD8⁺ T cell traffcking should reveal key mechanisms in T cell differentiation and protective immunity, and …
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Effects of Pharmacological and Genetic Disruption of Chemokine Receptor Cxcr4 In B-Cell Acute Lymphoblastic Leukemia
<p>The CXCR4 chemokine receptor plays a pivotal role in homing and retention of B-cell Acute Lymphoblastic Leukemia cells to bone marrow niches. The bone marrow stromal cells (BMSCs) constitutively secrete the CXCR4 ligand CXCL12, thus attracting leukemia cells and protecting them from cytotoxic …
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Generation of a novel pan-cancer chemokine receptor-modified CAR-T cell therapy directed towards nfP2X7
… towards the nonfunctional form of the P2X7 receptor (nfP2X7), which is an ATP receptor expressed by a diverse range of malignant cells that is completely absent on healthy tissues. This is the first use of nfP2X7 as a target antigen for CAR-T cell therapy and represents one of the first …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
The significance of chemokines in directing cell migration both during homeostasis and immune responses has been appreciated for some time. However, the mechanisms in place to post-translationally regulate cell migration through chemokine modulation are only recently becoming clear. CCX-CKR is a …
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Phylogenetic Analysis of Human Cytomegalovirus pUS27 and pUS28: Ascertaining an Independent or Linked Evolutionary History
… the acquisition of four virally encoded GPCR chemokine receptor homologs, products of the US27, US28, UL33 and UL78 genes. G protein-coupled receptors (GPCR) are the largest family of cell surface proteins, found in organisms from yeast to humans. In this research, phylogenetic analysis was …
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