Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 373 for “"chemokine"”.
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis.
Expression of chemokines CXCL10 and CCL2 is elevated within inflammatory lesions in the central nervous system (CNS) of multiple sclerosis (MS) patients, particularly in astrocytes. These chemokines play a critical role in the recruitment of inflammatory cells into the CNS during inflammation. …
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in …
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ST2 & TLRs: coordination of chemokine-driven immunity
… ligand by inducing the release of inflammatory chemokines but not cytokines. The migration of inflammatory cells into inflamed tissue is influenced by their recognition of chemokines. The expression of receptors for these chemokines, the so called chemokine receptors (CCRs) is therefore pivotal …
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Configurationally restricted bis-tetraazamacrocyclic complexes: chemokine receptor antagonists
The chemokine receptor CXCR4 is a trans-membrane protein which has been implicated in many physiological and pathological processes including cancer, rheumatoid arthritis and most significantly HIV replication. CXCR4 plays a vital role in embryonic development but is not essential at the …
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Regulation of cytokine and chemokine production in macrophages
… pathways regulating production of cytokines and chemokines in response to PRR agonists.<br/>Interleukin (IL)-10 is a potent anti-inflammatory cytokine which suppresses the production of pro-inflammatory cytokines such as TNFa, IL-6 and IL-12. In this thesis, a requirement for an interferon …
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Molecular Mechanisms Regulating Chemokine Receptor CXCR4 Signaling and Trafficking
… receptor (GPCR) that binds to the chemokine, stromal cell-derived factor-1 (SDF-1alpha; a.k.a. CXCL12). The SDF-1alpha/CXCR4 signaling axis plays an essential role during embryogenesis in the development of the heart, brain and vasculature and in the adult mediating immune cell …
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Investigation of chemokine expression and modulation following traumatic brain injury
… described. Chemotactic cytokines, known as chemokines, are mediators of leucocyte recruitment and activation. Expression of chemokines and the resultant recruitment of leucocytes into the brain are generally thought to be integral to the enlargement of cerebral contusions which accompany …
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On the role of mast cells in chemokine-induced leukocyte recruitment
… of inflammatory mediators, such as TNF-alpha and chemokines. Chemokines are effective leukocyte attractants and according to structural properties, chemokines are divided into two major subfamilies, CC and CXC. In general, CC chemokines exert chemotactic influence on monocytes and lymphocytes …
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Pharmacological insights into C-‐C motif chemokine receptor 5 mediated chemotaxis
… being well validated as a therapeutic target, no chemokine receptor antagonists to be used as therapeutic agents in inflammatory or metastatic disease have made it to market. This is in part due to receptor redundancy, but also a lack of understanding with regard to cytoplasmic signal transduction …
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CHARACTERIZATION OF HCMV-ENCODED CHEMOKINE RECEPTOR US28 TRANSDUCED MSU1.1 HUMAN FIBROBLAST CELLS
<p>Human Cytomegalovirus (HCMV) encodes the G-protein coupled receptor US28. Using a mouse model system, US28 was previously found to be oncomodulatory, increasing proliferation, inducing anchorage independent growth and loss of contact inhibition. Similarly, in the human glioblastoma cell line …
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Statin-Mediated Attenuation of Chemokine Expression in Peripheral Nerve Vascular Endothelial Cells
… By up-regulating endothelial expression of chemokines and cell adhesion molecules (CAMs), TNF-α facilitates the recruitment and trafficking of autoreactive leukocytes across the blood-nerve barrier and into peripheral nerves, an early pathological hallmark of GBS. Literature indicates that …
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Chemokine Ligand-3 (CCL3) as a Novel Mediator of Inflammatory Bowel Disease Activity
… by pro-inflammatory macrophage polarization. Chemokine ligand-3 (CCL3) is a chemokine known to mediate Th1 responses in inflammatory conditions and act to polarize M1 macrophages at the site of inflammation. CCL3 is upregulated in patients with IBD but its contribution to disease …
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Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists
The chemokine receptor CCR5 has been implicated in the pathogenesis of cancers and AIDS. A series of novel piperidine derivatives were designed, synthesized, and evaluated as CCR5 antagonists. The ability of the new ligands to inhibit the increment of intracellular calcium level stimulated by …
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LL-37 and citrullinated LL-37: differential modulation of the oxylipin - chemokine axis
… bronchial epithelial cells release cytokines/chemokines, and other mediators such as bioactive lipids and cationic host defence peptides (CHDPs) to facilitate and regulate airway inflammation. Oxylipins are bioactive lipids that are key mediators in the process of inflammation. The human host …
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cDNA microarray Analysis Identifies Symptom-Associated Chemokine Genes in Behcet's Disease Mouse Model
Behcet's disease(BD), a chronic inflammatory disease, is characterized by intraocular inflammation, oral ulcers, genital ulcers, skin lesions and additional accompanying changes. A developing aspect of BD is reached until eye symptoms are present from early mucocutaneous symptoms via arthritic and …
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