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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 197 for “"chemical synthesis"”.
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Chemical Synthesis Of Peptides And Peptide Thioesters
… the development of a new chemistry for the block synthesis of peptides and peptidyl thioesters. A direct approach for the Fmoc-SPPS of peptidyl thioesters is also delineated in this thesis.</p> <p>In the first part of chapter one, the difficulty and importance of chemical synthesis of peptides is …
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New CO₂ chemistry for fine chemical synthesis
There is a great need in the chemical industry for developing CO2 as a C1 building block as an important step towards "green chemistry". CO2 is also attractive as a chemical feedstock because it is readily available, inexpensive, nontoxic and it can replace toxic building blocks such as phosgene …
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Scale-up of continuous chemical synthesis systems
Continuous flow systems for chemical synthesis have become increasingly important in the pharmaceutical and fine chemical industry in the past decade. Initially, this work was confined primarily to microfluidic systems, but recently there has been a growing demand for milliscale systems capable of …
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Advancements in green chemistry approaches to chemical synthesis
Green chemistry approaches in chemical synthesis aim to reduce environmental impact while improving the efficiency and sustainability of chemical processes. In this work, we present two significant advancements in this field. First, the introduction and development of a non-pyrophoric version of …
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Chemical synthesis of glycosylated oligoribonucleotides for siRNA development
… UlO-mer and dimannosyl UlO-mer. In the synthesis of aromatic fluorescent ribosides, perbenzylated ribofuranosyl pyrene and phenanthrene were synthesized from perbenzylated ribolactone. Deprotection of benzyl-protected ribofuranosyl phenanthrene and pyrene by boron tribromide gave …
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Chemical Synthesis of Novel Calcium-Dependent Lipopeptide Antibiotics
… A and cadaside B utilising solid-phase peptide synthesis (SPPS). Chapter 1 gives an introduction to the problem of antibacterial resistance and an overview of clinically relevant AMPs and AMPs discovered in recent years. A summary of SPPS techniques is also provided. Chapter 2 gives an overview …
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The Chemical Synthesis of Model Catalysts Related to Enzymes
<p>The chemical synthesis of highly specialized peptides that might possess catalytic action provides one of the approaches to an understanding of the mechanism of enzyme action. The experiments reported in this thesis involve the chemical synthesis of model compounds designed to explore how …
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CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF CHONDROITIN SULFATE DISACCHARIDES
Glycosaminoglycans (GAGs) are heterogeneous polysaccharides comprising of repeating uronic acid and amino sugar disaccharide units. Recently, it was shown that the sulfate groups present in chondroitin sulfate GAGs (CS) encode important functional information for the regulation of physiological …
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Chemical synthesis in the campaign against Gram-negative pathogens
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Automated chemical synthesis for accelerated discovery of organic electronic materials
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Stereoselective and Economical Methods for Chemical Synthesis of Essential Medicines
… by allowing the exploration of diverse chemical space during drug discovery, and by encouraging the development of economical and sustainable solutions in active pharmaceutical ingredient (API) manufacturing. For a given API, a single stereoisomer often displays preferable chemical and …
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Design, Chemical Synthesis and Biological Evaluation of Potential New Antiviral Agents
… of interaction energy with the viral enzyme. Chemical synthesis was carried out together with structural characterization by extensive spectroscopic analysis including NMR technique and mass spectrometry. In particular, the synthesis of the amide group present in the structure of some …
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The Chemical Synthesis and Biological Fate of Tritium Labeled Linoleic Acid
Made available in DSpace on 2014-12-09T14:36:45Z (GMT). No. of bitstreams: 1 6402961.pdf: 4162072 bytes, checksum: c561f71fbd5d7fd27cf4965c616a5cfe (MD5) Previous issue date: 1963
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Engineering Chemistry: Integrated Control Strategies and Internet-Enabled Tools for Chemical Synthesis
… technologies and continuous methods to enhance chemical synthesis is a vibrant area of research, gaining increasing attention from laboratories in academia and industry. Yet many prominent synthesis procedures have not changed for decades and require significant manual intervention from bench …
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Silica mesocellular foam and carbon nanofoam for fine chemical synthesis and separation
… We have successfully created a new three-step synthesis of spherical MCF (S- MCF) particles utilizing sodium fluoride as a condensation catalyst. The approach allowed for independent control over S-MCF particle and pore size, and was extended to other non-ordered porous silicas. The S-MCF …
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Chemical synthesis of <em>Leishmania </em>lipophosphoglycan structures conjugated to a biotin moiety
Leishmaniasis is the second largest parasitic killer in the world (after malaria) responsible for an estimated 500,000 cases each year worldwide. Visceral leishmaniasis infections (i.e. internal organs) are more complicated to diagnose due to the lack of visible symptoms. Current tests of the …
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Chemical Synthesis of Cyclopropenoid Fatty Esters and Their Inhibition Ofthe Liver Desaturase System
Made available in DSpace on 2014-12-10T22:38:16Z (GMT). No. of bitstreams: 1 7114994.pdf: 3274102 bytes, checksum: e840d91bee3adcfd069d0996af23c428 (MD5) Previous issue date: 1970
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The Discovery and Chemical Synthesis of Peptides and Proteins that Cross Biological Barriers
… lateral sclerosis and frontotemporal dementia. Synthesis of these proteins by biological or chemical means has previously proved difficult, due to their toxicity and propensity towards aggregation. Herein we report the chemical synthesis of four DPRs using automated fast-flow peptide synthesis. …
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