Global ETD Search
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Showing 1 to 1 of 1 for “"chemical probe design"”.
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Analyzing Resistance to Design Chemical Inhibitors of AAA Proteins
… alleles can thus reveal and suggest the biochemical determinants of the drug's selectivity and potency. In this thesis, I explore how mutations in active sites of proteins can be leveraged to understand inhibitor binding and to design selective chemical inhibitors. In my thesis work I focus …