Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"chemical mixtures"”.
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Chemical Mixtures of Xenoestrogens and Their Metabolites Alter Estradiol-Induced Non-Genomic Signaling
… responses to these compounds alone, as mixtures, as metabolites and congeners, and in combination with estradiol (E2), while also automating these assays to facilitate future screening of a potentially large number of XEs. METHODOLOGY: Environmentally relevant concentrations of XEs …
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Immunotoxicity of Dermal Permethrin and Cis-Urocanic Acid: Effects of Chemical Mixtures in Environmental Health
… effect that became more than additive when the chemicals were administered concurrently. Defects in antigen processing and presentation by cutaneous Langerhans cells were evaluated as possible contributing mechanisms to the cutaneous immunosuppression, using mice with deleted genes. …
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Evaluating Competitive Sorption Mechanisms of Volatile Organic Chemical Mixtures in Soils and Sediments Using Polymers and Zeolites
Volatile organic chemicals (VOCs) such as chlorinated compounds are among the most problematic groundwater contaminants. Prior research suggests that VOC mixtures compete for micropore sorption sites present in soils and sediments. It is hypothesized that the size and polarity of these micropores …
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Validation of the Planarian Bioassay With Defined Mixtures and Testing Against Other Bioassays With Contaminated Samples From Pakistan
… to assess toxicologic effects caused by pure chemicals and chemical mixtures; (b) assess chemical contamination in environmental samples from selected areas in Pakistan where industrial contamination was suspected; (c) test the sensitivity of the planarian model and other bioassays to …
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DEGRADATION OF PROTECTIVE GLOVE MATERIALS EXPOSED TO COMMERCIAL PRODUCTS: A COMPARATIVE STUDY OF TENSILE STRENGTH AND GRAVIMETRIC ANALYSES
… which type of glove is appropriate for handling chemicals; however, they include information on less than 1% of the 89 million chemical products available today.</p> <p>This study offers a solution by testing five durable polymer materials against 50 chemicals, using two rapid chemical …
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An Empirical Approach to Evaluating Sufficient Similarity: Utilization of Euclidean Distance As A Similarity Measure
Individuals are exposed to chemical mixtures while carrying out everyday tasks, with unknown risk associated with exposure. Given the number of resulting mixtures it is not economically feasible to identify or characterize all possible mixtures. When complete dose-response data are not available on …
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Engineering Organoids for Stem Cell Maturation
… approaches require the administration of chemical mixtures that can be up to a million times higher than the concentrations of these same molecules inside the body. The lack of a systematic approach to mature iHLCs currently limits their widespread use. During liver development, …
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Chemical Micro Preconcentrators Development for Micro Gas Chromatography Systems
… of MEMS is to develop micro instruments for chemical analysis. An example is gas chromatography (GC) which is widely used in food, environmental, pharmaceutical, petroleum/refining, forensic/security, and flavors and fragrances industries. A MEMS-based micro GC (µGC) provides capabilities …
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Evaluating Chemical Toxicity: A Novel Behavioral Assay Using Daphnia
… ultimately affect fitness and survival. These chemicals are often found in the environment as complex mixtures, and this complicates their evaluation of their toxicity. There is a need for high-throughput assays to rapidly assess the toxicity of these emerging contaminants. A behavioral assay …
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Corporate bodies and chemical bonds : an STS analysis of natural gas development in the United States
… into subsurface shale formations of synthetic chemical mixtures, has been viewed by the natural gas industry as a practice of great promise. But there is another side to the story. The first half of this dissertation explores an innovative scientific approach to studying the possible …
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Thyroid hormone action and disruption in the brain: Xenopus as a model to study disruption of thyroid hormone availability on early brain development
… and IQ loss. On average, over 30 anthropogenic chemicals are present in all American women, with 15 being ubiquitous, including in pregnant women. Many of these chemicals are demonstrated or suspected TH disruptors. A representative mixture of these 15 common chemicals was established at …
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The Development of Computational High-Throughput Approaches for Screening Metal-Organic Frameworks in Adsorptive Separation Applications
Chemical separation undoubtedly accounts for a large proportion of process industries’ activities. In the past few decades, 10-15% of the world’s energy consumed was resulted from separation process. Tremendous efforts have been made in separating the components of large quantities of chemical …
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Hyphenation of analytical techniques to single cell capillary electrophoresis-mass spectrometry
Single cell chemical analysis pushes the limits of analytical measurements. Small volumes, large dynamic range, and chemical complexity all contribute to the analytical challenge of investigating single cell biology. To comprehensively study single cell chemistry, technologies require low limits of …
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Compound Events and Exposure Science: Characterizing Mixtures and Assessing Cumulative Risks Using Participatory Research Methods
… exposures, integrating environmental monitoring, chemical mixture analysis, climate-driven exposure pathways, and community-based research. Rather than focusing on a single pollutant, it examined metal(loid)s, per- and polyfluoroalkyl substances (PFAS), polycyclic aromatic hydrocarbons (PAHs), and …
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Pesticide Mixtures Induce Immunotoxicity: Potentiation of Apoptosis and Oxidative Stress
… cytotoxicity assay, individual pesticide and mixtures of malathion/PBO (MP) and malathion/lindane (ML) prompted cytotoxicity with varying intensities (Mal 18.8%, Lind 20.4%, PBO 23.5%, ML 53.6% and MP 64.9%). Cytopathological analysis revealed apoptotic features in treated cells and the DNA …
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Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust
… γ (PPARγ) nuclear receptor. To date, very few chemicals have been identified as possible PPAR ligands. In the thesis, our goal was to determine the PPARγ ligand binding potency and activation of several groups of major semi-volatile organic compounds (SVOCs) that are ubiquitously detected in …