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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 55 for “"chemical inhibition"”.

  1. Structural Characterization and Chemical Inhibition of the ARNT/TACC3 Complex

    Guo, Yirui2017

    … complex with various biophysical and biochemical methods including solution NMR, X-ray crystallography, circular dichroism, luminescence proximity and numerous cell-based assays. A 3.15 Å ARNT/TACC3 crystal structure was solved by molecular replacement, revealing details of this protein …

    utswmed Repository record

  2. The effect of oxidation-reduction potential on the outgrowth and chemical inhibition of Clostridium botulinum type E spores

    Smith, Merton VincentVirginia Tech1975

    … mv), and reduced (Eh = -190 mv) media. However, inhibition by sodium chloride (3.5% and 4.0%), hydrogen ions (pH 5.11 and 5.05), and sucrose (30% and 35%) revealed an increased lag phase and a decreased maximum absorbance for growth in the oxidized medium compared to growth in the reduced medium. …

    vt Repository record

  3. The effect of oxidation-reduction potential on the outgrowth, toxin production, and chemical inhibition of Clostridium botulinum type A spores

    Smoot, Leslie A.Virginia Polytechnic Institute and State University1977

    … (Eh) on the outgrowth, toxin production, and chemical inhibition of Clostridium botulinum type A spores was investigated. Growth, toxin formation, and Eh7 changes were monitored in an airtight four necked flask containing electrodes for continuous measurement of Eh and pH and connections for …

    vt Repository record

  4. Chemical Inhibition of Nitrification: Evaluating Methods to Detect and Characterize Inhibition and the Role of Selected Stress Responses Upon Exposure to Oxidative and Hydrophobic Toxins

    Kelly, Richard Thomas, IIVirginia Tech2005

    This research first examined nitrification inhibition caused by different classes of industrially relevant chemicals on activated sludge and found that conventional aerobic nitrification was inhibited by single pulse inputs of every chemical tested, with 1-chloro-2,4-dinitrobenzene (oxidant) having …

    vt Repository record

  5. INVESTIGATIONS OF DNA DAMAGE AND REPAIR IN THE HUMAN LENS

    Smith, AndrewUniversity of East Anglia2014

    … by western blot and immunocytochemistry. Chemical inhibition of PARP-1 activity was also undertaken. Results: A 24 hour exposure to hydrogen peroxide induced a concentration-dependent decrease in cell viability and increase in cytotoxicity and apoptosis. A 24 hour exposure to 1mM H2O2 …

    east-anglia Repository record

  6. Determination of Absolute Protein Content of Hepatic CYP4F Enzymes in Human Liver Microsomes Using LC/MS/MS Methodology and Comparison with Immunoquantification and Enzyme Activity

    Michaels, ScottUniversity of Kansas2013

    … metabolite formation rates for DB289 or DB1230. Chemical inhibition experiments were performed which provided additional evidence for the metabolism for DB289 and DB1230 by enzymes other than CYP4F enzymes. However, a lack of improved correlation for the chemical inhibition experiments suggest …

    ku Repository record

  7. Elucidating The Direct Role of M6A In The Human Transcriptome

    Al Hasani, Lana, <p>https://orcid.org/0009-0005-3443-5859</p>2025

    … through genomic alterations or transcript inhibition, but rather we focus on the direct targeting of proteins for degradation and rapid chemical inhibition of the m6A methyltransferase in a human cell model HCT116. This study allows for the direct analysis of the m6A modification in RNA …

    uthsc Repository record

  8. Design and Synthesis of Thiamine Pyrophosphate (TPP) Analogues for Investigating the Structure-Activity Relationship (SAR) of Inhibitors of TPP-dependent Enzymes

    Chan, Hok Yan AlexUniversity of Cambridge2023

    … significantly in substrate preferences and biochemical reactions. To study these enzymes by chemical inhibition, the most popular way is to use thiamine/TPP analogues, which typically feature a neutral aromatic ring in place of TPP’s positive thiazolium ring. In response to the growing demand …

    cambridge Repository record

  9. PRMT5 Inhibitors in Merkel Cell Carcinoma

    Higgins, Kathleen WhitmoreMassachusetts Institute of Technology2021

    … a new therapeutic strategy for MCC based on chemical inhibition of protein arginine methyltransferase 5 (PRMT5). PRMT5 inhibitors are already being tested in a variety of other solid and liquid tumors to good effect. Our data suggest that PRMT5 inhibitors may be effective in treating a …

    mit Repository record

  10. Investigations into the Mechanisms that Are Responsible for Reduction in Colonic SN-38 Exposure

    Basu, SumitUniversity of Houston2015

    … (2) investigate the potential of certain chemicals and natural products to reduce colonic exposure of SN-38 by inhibiting biliary and intestinal excretions of SN-38 and SN-38 glucuronide employing the modified in situ rat perfusion model; and (3) determine if the selected chemicals and …

    houston Repository record

  11. Host Modulators of the Death Response to Influenza A Infection

    Ward, Samuel Enoch2012

    … suicide checkpoint activation. Pharmacological inhibition of representative targets, RGGT and CHEK1, resulted in significant protection against infection of human epithelial cells by the A/WS/33 virus. In addition, chemical inhibition of RGGT partially protected against H5N1 and the 2009 H1N1 …

    utswmed Repository record

  12. Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells

    Brown, Wells S2014

    … pathway members are being discovered. We show chemical inhibition of RAF by Sorafenib or shRNA-mediated knockdown of B-Raf reduces T cell resistance to shear stress to α4β1 integrin ligands vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN), while inhibition of MEK/ERK by U0126 had …

    uthsc Repository record

  13. Nuclear receptor co-repressor functions in prostate cancer; in vitro, in vivo and in silico approaches

    Battaglia, SebastianoUniversity of Birmingham2010

    … when compared to non-malignant RWPE-1 cells. Chemical inhibition of NCOR1, via the HDAC inhibitor SAHA, or NCOR1 knock-down, via shRNA, restored PC-3 cells sensitivity to NR agonists with exception of Vitamin D and Thyroid Hormone T3. NCOR1-knock down led also to a re-expression of basally …

    birmingham Repository record

  14. Investigating the mitotic roles of Topoisomerase 2 Alpha and Topoisomerase 2 Beta-Binding Protein 1 in the maintenance of chromosome structure and genome stability

    Benoit, JudithUniversity of Cambridge2024

    … in human tumour-derived cell lines using both chemical inhibition and depletion (through siRNA and genetically modified cell lines) to disrupt the two isoforms. My findings indicate that, in cells in which chromosome compaction has already occurred (prometaphase-metaphase), either chemical …

    cambridge Repository record

  15. Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments

    Biehl, Matthew JosephUniversity of Illinois at Urbana-Champaign2017

    … mRNA or protein expression. We found that acute chemical inhibition of Notch signaling was sufficient to significantly reduce direct downstream Notch signaling Hes1, Hes5, and Hey1. This coincided with a significant increase in the proneural gene Mash1, suggesting that some of the machinery …

    uiuc Repository record

  16. Biomimetic approach to anti-fouling surfaces

    Cheong, Wen ChooUniversity of Leeds2010

    … approaches to remove and prevent scaling with chemical inhibition, chemical scale removers and mechanical methods being the most prevalent ones. Recently the focus has shifted onto more environmentally friendly inhibitors that are less toxic to the environment, thus the development of green …

    whiterose Repository record

  17. The role of PLK1 in NLRP3 inflammasome activation

    Baldrighi, MartaUniversity of Cambridge2020

    … PLK1 inhibitors, I demonstrated that PLK1 inhibition impairs the NLRP3 inflammasome pathway. Accordingly, PLK1 levels are tightly regulated over the course of NLRP3 inflammasome activation. I generated multiple in vitro PLK1 depletion models in macrophages and combined them with the …

    cambridge Repository record

  18. Characterization of a novel interaction between presenilin-1 and monoamine oxidase-A

    Gabriel, GeraldineUniversity of Saskatchewan2008

    … increase in MAO-A activity following in vitro chemical inhibition of the γ-secretase complex (comprising several proteins including PS-1) support the notion that PS-1 constitutively associates with MAO-A. These effects on Ca²⁺-sensitive MAO function could contribute to AD-related pathology and …

    sask Repository record

  19. Regulation of human sex-linked homologs DDX3X and DDX3Y and phenotypic consequences

    Rengarajan, ShruthiMassachusetts Institute of Technology2024

    … of the homologous gene to rise. In 46,XX cells, chemical inhibition of DDX3X protein activity elicits an increase in DDX3X transcript levels. This regulation is mediated through mRNA stability and buffers total levels of DDX3X and DDX3Y protein in human cells. Our findings indicate that gene …

    mit Repository record

  20. SMARCA4/BRG1-Inactivating Mutations as Potential Predictive Markers for Aurora Kinase A-Targeted Therapy in NSCLCs

    Tagal, Vural2016

    … mutations. RNAi-mediated depletion or chemical inhibition of AURKA induces apoptosis and diminish cellular viability in SMARCA4/BRG1-mutant NSCLC cells in vitro and in mouse models. The relation between SMARCA4/BRG1 inactivation and increased requirement for AURKA appears to be due to …

    utswmed Repository record

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