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Showing 1 to 20 of 36 for “"chemical exchange"”.
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Kinetics of chemical exchange during melting of planetary interiors
… are used to place constraints on the kinetics of chemical exchange during partial melting within the mantles of the terrestrial planets. Chapter 1 presents experiments on the diffusion rates of La, Ce, Nd, Dy and Yb in diopside at pressures of 0 to 2.5 GPa and temperatures of 1050 to 1450 'C. The …
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Methods for chemical exchange saturation transfer magnetic resonance imaging
Chemical exchange saturation transfer (CEST) is a relatively new magnetic resonance imaging (MRI) acquisition technique that generates contrast dependent on tissue microenvironment, such as protein concentration and intracellular pH. CEST imaging has the potential to become an important biomarker …
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Nuclear Magnetic Resonance Studies of Molecular Association and Proton Chemical Exchange
Made available in DSpace on 2014-12-05T19:37:20Z (GMT). No. of bitstreams: 1 6001624.pdf: 3345284 bytes, checksum: 92418b1def350b1d7d90ad02ef68a60f (MD5) Previous issue date: 1960
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Spin Echo Studies of Chemical Exchange Internal Rotation in 1,1-Difluoro-1,2-Dibromodichloroethane
Made available in DSpace on 2014-12-09T17:35:42Z (GMT). No. of bitstreams: 1 6706764.pdf: 2449766 bytes, checksum: 55b75a23325272c6a00be4cc12b39388 (MD5) Previous issue date: 1966
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SIMULTANEOUS ARTIFACTS CORRECTION AND ACCELERATION FOR CHEMICAL EXCHANGE SATURATION TRANSFER IMAGING VIA DEEP LEARNING
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a novel technology for precise diagnosis of various diseases using either endogenous molecules or exogenous administered contrast agents. CEST MRI methods rely on molecular signal saturation through …
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NMR Sensing Strategies Based on Modulation of Chemical Exchange Rate With Small-Molecule Synthetic Sensors
… on NMR spectra in response to variations in chemical exchange rate. Molecular strategies in which the chemical exchange rate is deliberately controlled can lead to attractive opportunities in NMR sensor design. This thesis explores two main strategies involving structurally similar sensors in …
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Double volumetric navigators for real-time simultaneous shim and motion measurement and correction in Glycogen Chemical Exchange Saturation Transfer (GlycoCEST) MRI
… as glycogen metabolism in sports physiology. Chemical Exchange Saturation Transfer (CEST) MRI has emerged as a non-invasive contrast enhancement technique that enables detection of molecules, like glycogen, whose concentrations are too low to impact the contrast of standard MR imaging. CEST …
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Ligand Donor Properties: I. Spectral Studies of Alcohol and Pyridine-1-Oxide Ligands in Transition Metal Complexes. Ii. Chemical Exchange Rates in Nickel(ii) Alcohol Complexes by Nuclear Magnetic Resonance
Made available in DSpace on 2014-12-09T17:35:03Z (GMT). No. of bitstreams: 1 6503604.pdf: 5212285 bytes, checksum: 74b3087da42c477a5dc261f94b12a996 (MD5) Previous issue date: 1964
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Novel Simulation to Avoid Bias In Measurement of Hyperpolarized Pyruvate: Demonstrated In Phantom and In Vivo
… Real-time imaging of both the spatial and chemical fate of hyperpolarized metabolites is showing great promise to meaningfully benefit clinical care of cancer patients. Imaging of hyperpolarized agents will have a larger clinical impact if it can function as a quantitative modality upon …
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Potassium Metasomatism and Diffusion in Cretaceous K-Bentonites From the Disturbed Belt, Northwestern Montana and in the Middle Devonian Tioga K-Bentonite, Eastern u.s.a. (Illite/smectite, Clays, Diagenesis, United States)
… study is to determine the kind and extent of chemical exchange between bentonite beds and shale host rocks during K-bentonite formation.
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In situ High Pressure and Temperature 13C NMR for the Study of Carbonation Reactions of CO2
… Critical observations about reaction rates, chemical exchange, and pH measurements throughout these reactions and the implications of the in situ measurements made during these reactions are discussed. A new method is used to elucidate pH under high pressure and temperature conditions which …
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New Chemistry of Transition Metal Alkyls and Hydrides: Bonding and Reactivity
… +], the two hydride ligands undergo chemical exchange on the NMR time scale with activation free energies of 17.5 and 16.9 kcal mol-1 , respectively. Protonation of all the (C5Me5)Os(PR 3)2H complexes at low temperature affords the cisoid isomers, which must be the kinetic products. …
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Hydration and Water Distribution Studies of Heart Muscle by Nuclear Magnetic Relaxation
… compartments in the heart muscle. A deuterium exchange study is undertaken to obtain additional information concerning the chemical exchange of water protons/deuterium within these compartments, and the effects of proton intermolecular dipolar interactions on proton transverse relaxation of …
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Development of a hydrogel-based biocompatible platform for studying metabolic interactions between algae and bacteria
… cycling in ocean ecosystems. To date, studying chemical exchange between these microbial species based on molecular diffusion processes has been challenging due to a lack of an appropriate co-culture system. In this thesis, a hydrogel-based biocompatible platform is proposed to study the …
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Nuclear magnetic resonance studies of corn zeins and other byproducts of corn wet milling: Dynamic and structural basis of functionality
… relaxation measurements were complicated by chemical exchange effects which were estimated to be as much as 50% of the observed relaxation rate for $\sp2$H NMR measurements of corn zein solutions. Subsequently, correlation times calculated from $\sp2$H NMR measurements were anomolously long. …
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Potentiation of The Immune Checkpoint Blockade Response By Metabolic Modulation Is Predictable Using Molecular Imaging
… day before beginning ICB treatment. Using acido-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging (acidoCEST MRI), pHe of 4T1 tumors after esomeprazole can predict response to combination therapy, as indicated by increased T cell activation. However, the change in B16-F10 pHe after …
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IMAGING THE GLUTAMATERGIC SYSTEM WITH GLUCEST MRI: CYTOARCHITECTURE, AGING, AND INTERVENTION
… disorder. Ultra-high field 7T glutamate-weighted chemical exchange saturation transfer (GluCEST) imaging is emerging as a promising biomarker for in vivo glutamatergic function. This work addresses critical gaps in the literature and explores glutamatergic underpinnings of aging, depression, and …
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Accelerated Quantitative Magnetization Transfer (qMT) Imaging
… imaging techniques including qMT and chemical exchange saturation transfer (CEST). This thesis uses sparseSENSE, a combined parallel imaging and compressed sensing technique, to accelerate MT-weighted images. In this thesis, sparsifying reconstruction algorithms are shown to enable …
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The Use of Driven Equilibrium Conditions in the Measurement of NMR Relaxation Times
… of the use of NMR relaxation times in chemical, biological and medical research has perhaps been curtailed by the length of time these measurements often take. The DESPOT (Driven Equilibrium Single Pulse Observation of T1) method has been developed, which reduces the time required to …
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From the body to the brain: Studying drug delivery and physiological interactions using MRI
… delivery and understanding the propensity for chemical exchange across the BBB. We then used one of the widefield brain delivery techniques to apply a novel contrast agent for the study of the cholinergic system, a neurochemical pathway important for motor control mechanisms in both the central …
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