Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"chemical diversity"”.
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The chemical diversity of midge pheromones
… was that midge sex pheromones could be chemically more diverse in structure than previously thought. This hypothesis was tested in the context of four midge species of importance to UK horticulture: pear leaf midge, Dasineura pyri, pear midge, Contarinia pyrivora, blackcurrant midge, D. …
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Novel algorithm for elucidating biologically relevant chemical diversity metrics
… to have similar or better activity. Many popular chemical diversity metrics do not perform very well in this role. A new emphasis on identifying diversity metrics that also encode biological trend information is thus emerging as a desired tool for guiding the assembly of targeted screening …
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Ancient Triassic Halite as a novel source of antibiotic chemical diversity
… of the bioactive(s) using TLC-overlays, biochemical tests, and LC-MS/MS analysis excluded structural similarity to known AHL molecules, suggesting that it may be a chemically modified AHL or a DKP. Fractionation of the crude extract revealed that fraction nine induced pyoverdine production, …
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Investigating the chemical diversity and biomedicinal potential of South African actinomycetes for tuberculosis drug discovery
The chemical diversity and biomedicinal potential of three South African actinomycetes, Streptomyces speibonae PK-BlueT , Streptomyces africanus CPJVR-H T and Streptomyces pharetrae CZA14T , was investigated. The primary aim was the isolation and structure elucidation of anti-tubercular natural …
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Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents
… reactions offer the advantage of introducing chemical diversity in fewer steps than conventional multi step organic synthesis. New chloroquine-type compounds were designed and synthesized using the Ugi 4 component condensation reaction and its variants. The synthesized compounds ranged from …
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Natural Product Biosynthesis In Uncultured Bacteria
… (eDNA) has begun to provide access to the chemical diversity encoded in the genomes of previously uncultured bacteria. The systematic exploration of natural product biosynthesis in uncultured bacteria, however, still faces several challenges that we sought to experimentally address. First, …
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Growth-induced non-stoichiometry in complex oxide systems
… different functionalities is owed largely to the chemical diversity available to the perovskite unit cell, opening the door for metal-insulator-transitions, ferroelectricity, and superconductivity, to name a few. However, the same chemical diversity that enables so many potential applications also …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
The chemical diversity found in plants has served as a major source of inspiration to many synthetic and biological chemists. Nature has evolved enzyme active sites to catalyze the synthesis of structurally complex compounds that serve as pharmaceuticals, insecticides, dyes, perfumes, and biofuels. …
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Pheromones, nectar, and computer vision: investigating large-scale patterns of chemodiversity.
At its core, chemical ecology attempts to describe the complex forces that generate the vast chemical diversity observed in nature and which allow natural products to mediate interactions across biological scales. Chemodiversity is a major component of functional biodiversity in all ecosystems, and …
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Identification of potential antibiofilm hit compounds from two African natural product database against multi-drug resistant staphylococcus aureus: an in silico study
… due to sporadic and patchy data. The complex chemical diversity of natural compounds makes them a reservoir of bioactive molecules for drug discovery. This study seeks to identify effective potential antibiofilm compounds from a query dataset compiled from two African natural product databases …
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Selective Chemical Reactions for Nucleic Acid Sequencing and DNA-Encoded Library Synthesis
… campaign involving a DEL depends on the chemical diversity presented within the DEL; methods that can generate DELs with new molecular architectures and with greater chemical diversity are critically needed to advance drug discovery efforts both within industry and academia. To this end, …
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Studies Towards the Discovery of Novel Natural Products Through Functional Analysis of Environmental DNA-Encoded Type II Polyketide Synthases
… remained a significant challenge to access the chemical diversity present in these microorganisms using culture-based methods. Most modern natural product discovery efforts are faced with the hurdle of high rediscovery rates (>99%) of known metabolites produced by easily cultured bacteria. …
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Designing Macromolecules using Machine Learning and Simulations
… of macromolecules. However, such chemical diversity hinders the development of general computational approaches that can be applied to macromolecules. The challenges around representing, comparing and learning over macromolecules are manifold. Current representations provide …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… Natural compounds like maslinic acid expand chemical diversity, while repurposing candidates such as CRS3123 and ridinilazole accelerate potential clinical application. This thesis provides new insights into strategies for combating multidrug-resistant Enterococcus, a pathogen of urgent …
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Biochemical Characterization of the DUF3328 Protein in the Biosynthesis of Cyclic Peptide Cyclochlorotine
… They exhibit significant biological and chemical diversity. Cyclochlorotine, a fungal cyclic pentapeptide produced by Talaromyces islandicus, possesses unique structural modifications, including dichlorination and hydroxylation, yet the enzymatic basis for these transformations remains …
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Induced defenses in apple fruits: linking fruit chemistry, quality, and plant-insect-microbe interactions
Plants synthesize a diverse array of phytochemicals in response to interactions with herbivores, pathogens, and commensal microbes. These phytochemicals may simultaneously enhance crop defense and quality, representing a potential pest management strategy. However, plant chemical responses to …
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Computational studies of the self-cleavage mechanism in the glmS ribozyme
… To overcome the lack of structural and chemical diversity, ribozymes employ several interesting strategies for catalysis. The glmS ribozyme regulates the level of glucosamine-6-phosphate (GlcN6P) in bacteria by catalyzing a self-cleavage reaction. Namely, the GlcN6P bonds to the glmS …
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