Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"chemical biology tools"”.
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Chemical Biology Tools to Study Bacterial Cell Surface Glycans
… address this open challenge, we developed novel chemical biology tools to study bacterial cell surface glycans. We have established a new, generalizable strategy for chemoselective glycan modification to enable the study of specific bacterial cell wall glycans. Our method relies on the direct …
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Chemical Biology Tools for Biochemical and Functional Analysis of Myosin Phosphatase
… the PPP1R12C–PP1cβ holoenzyme using a suite of chemical biology tools. To overcome challenges posed by PPP1R12C’s intrinsic disorder and the dynamic assembly of the complex, we employed mammalian expression systems and AlphaFold modeling to predict structure and optimize expression. A …
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Development of fluorescent chemical biology tools for the detection and delivery of aldehyde-associated biology
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Development of Novel Chemical Biology Tools for Probing Structure-Function Relationships in G Protein-Coupled Receptors
… extracellular signals into intracellular biochemical responses. Understanding with chemical precision how GPCRs function in cellular membranes is an active area of biological research, but despite recent reports of X-ray crystal structures of several GPCRs, some important questions remain …
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Development of novel chemical biology tools to probe malaria parasite physiology and aid in antimalarial drug discovery
… is especially challenging due to the unique biology of malaria parasites, the scarcity of tools for identifying new drug targets, and the poorly understood mechanisms of action of existing antimalarials. Therefore, this work describes the development of two chemical biology tools to address …
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Targeting Virulence as an Approach to Bacterial Pathogenesis: Efforts Towards the Development of Chemical Biology Tools and Anti-Chlamydial Therapeutics
… is a need for the discovery and development of chemical biology tools that can be used to probe the function of chlamydial effectors, and in turn possibly reveal therapeutic targets for antibiotic development. Here we report efforts toward the design, synthesis, and evaluation of small molecules …
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Methods to study protein folding and evolution in vivo
… that has focused on addressing the limitation in chemical biology tools for studying proteostasis by developing chemical genetic methods tune the level of proteostasis components. Similarly, the inability to conveniently explore protein folding and fitness landscapes on the laboratory timescale …
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Structure-activity relationship studies and biological evaluation of selective sphingosine kinase inhibitors
… in blood decreased. These molecules provide the chemical biology tools to determine the effect of modulating S1P levels in vivo. We also focused our investigation on the tail region of the pharmacophore. From this study, SLM6031434 and SLM6041418 were discovered and both proved to be more potent …
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Role of O-GlcNAc in the Vertebrate Secretory Pathway
… changes, or degradation. However, the biochemical effects of O-GlcNAc on the vast majority of substrates is unknown. Recently, we and others have shown that several coat protein complex II (COPII) components including SEC23A, SEC24C, and SEC31A are O-GlcNAcylated. The COPII coat complex …
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Approaches to Study Small Molecule Inhibitors and Their Targets
<p>Bioactive small molecules are valuable tools to understand and manipulate biological pathways. In order to be effective as either probes for understanding cell biology or as clinical drugs, the small molecule's mechanism of action must be characterized. However, identifying a small molecule's …