Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"chelator"”.
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Studies of an Endogenous Zinc Chelator of Rat Intestine
Made available in DSpace on 2015-05-13T15:26:57Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7811289.PDF: 3236861 bytes, checksum: b4cd6a6b68fc527193f094671e8c7c52 (MD5) Previous issue date: 1978
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Lignocellulose deconstruction using glyceline and a chelator-mediated Fenton system
… of the biomass components, and 2) a chelator-mediated Fenton reaction (CMF) that chemically modifies the nanostructure of the cell wall through a non-enzymatic cell wall deconstruction. After pretreatment, utilizing analytical techniques such as nuclear magnetic spectroscopy, wide …
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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
… advancement of potential antioxidant and iron chelator therapies for PD, limiting factors such as brain penetrance and bioavailability need to be overcome. This study aimed to develop novel nanocarrier delivery systems of the antioxidants curcumin, n‐acetylcysteine (NAC) and hydroxytyrosol …
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Separation and Characterization of Reconstituted Skim Milk Powder Treated with Mineral Chelators
… added to milk systems, the CCP is bound to the chelator and removed from the micelle. It has been shown through past research that the use of calcium chelating agents disrupts the calcium phosphate equilibrium and allows for the dissociation of the casein micelle and release of the individual …
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Study of Rehydration Properties of Powder Produced from Chelated Skim Milk
… and solubility. Previous work has suggested that chelator addition during SMP manufacture leads to higher solubility compared to SMP without chelators. This study focuses on the addition of ethylene diamine tetraacetic acid (EDTA) or sodium citrate dihydrate (SCD) at concentrations of 5, 10, and …
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Development of Stimulus-Responsive Ligands for the Modulation of Copper and Iron Coordination
… photochemistry of aroylhydrazone metal chelator ((E)-N′-[1-(2-hydroxyphenyl)ethyliden]isonicotinoylhydrazide) (HAPI) and its relation to HAPI metal binding properties. Based on promising initial results, a series of HAPI analogues was prepared to probe the structure-function …
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FBS0701: un nuovo chelante orale nel trattamento del paziente con sovraccarico trasfusionale di ferro
… clinical need for a well-tolerated and safe iron chelator for the treatment of transfusional iron overload. The objective of this study was to assess the safety, tolerability and dose response of FBS0701, a novel oral iron chelator. Design and Methods This phase 2 study to assess the safety, …
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Protein Semi-Synthesis in Vivo
… and a synthetic high affinity <sup>99m</sup>Tc chelator. Following protein semi-synthesis, the <sup>99m</sup>Tc was incorporated into the chelator and the <sup>99m</sup>TC-labeled protein was injected into mice bearing a tumor. The semi-synthetic VEGF localized onto the vascularized tumor and …
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On the transmission properties of synapses made between granule cells and cerebellar Purkinje cells
… of PFs without a high concentration of calcium chelator in the postsynaptic cell evokes LTD. In cerebellar slices from wild-type and transgenic, G-substrate knockout mice, 8Hz RFS was applied to PFs, with a low concentration of postsynaptic calcium chelator. In PCs from wild-type mice, LTD …
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Comparison of Silica Polyamine Composites and Crosslinked Polystyrene Resins
… demonstrated that while crosslinked polystyrene chelator resins sometimes exhibit higher equilibrium batch capacities, SPCs exhibit faster mass transfer kinetics and equivalent flow capacities, with higher or similar purity. Explorations into developing direct analogs of polystyrenes chelator …
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Comparison of Silica Polyamine Composites and Crosslinked Polystyrene Resins
… demonstrated that while crosslinked polystyrene chelator resins sometimes exhibit higher equilibrium batch capacities, SPCs exhibit faster mass transfer kinetics and equivalent flow capacities, with higher or similar purity. Explorations into developing direct analogs of polystyrenes chelator …
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Secondary Metabolite Production By An Endophytic Bacillus sp. from Platanus Occidentalis
… further exemplified by purifying a natural metal chelator, nicotianamine, from soy flour. This is a possible candidate to replace ethylenediaminetetraacetic acid (EDTA), a synthetic metal chelator used to prevent food spoilage. Further studies on possible endophytic production of nicotianamine …
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The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents
… agents. The synthesis of a series of lanthanide chelators based on DO3A bearing a benzimidazole or a benzyl derivative that can act as both a chromophore unit and a linking group for conjugation that has the functionality to couple to an optical dye (either rhodamine or BODIPY derivatives) is …
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Chemically Induced Phytoextraction of Lead (Pb) Contaminated Soil by Switchgrass (Panicum virgatum L.)
… Infuse (active ingredient propiconazole), the chelator nitrilotriacetic acid (NTA), and the phytohormones salicylic acid (SA) and benzylaminopurine (BAP) were tested on switchgrass grown in Pb contaminated soil from a former superfund site in Cedartown, GA. The soil chemical manipulation aimed …
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Mechanisms of Copper Deficiency in the Zebrafish Embryo
… model of severe copper deficiency. The copper chelator neocuproine causes a Menkes-like phenotype in wild-type zebrafish embryos and the mutant <italic>calamity</italic> which phenocopies neocuproine treated embryos contains a null allele of <italic>atp7a</italic>. In this thesis we build upon …
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Chemoligand therapy for metastatic castration-resistant prostate cancer
… of the drug built on the general structure of chelator-containing glutamate-ureido-based radiopharmaceuticals for radioligand therapy. After screening taxanes, auristatins, and maytansinoids as candidates for drug development, I conjugated the next-generation microtubule inhibitor monomethyl …
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I The synthesis and coordination chemistry of novel 1,1,1-tris(aminomethyl)ethane (TAME) derived ligands and their use as size selective fluorescent zinc(II) sensors II The synthesis of strongly and weakly binding ligands with nitrogen, oxygen, and sulfur-donor groups to be used as receptors in fluorescent ratiometric indicators for transition metal ions
… Ni(II)-mediated template synthesis of the novel chelator TAMEpyr, where TAMEpyr =N,N',N"-tris(2-pyridylmethyl)-1,1,1-tris(aminomethyl)ethane, and its coordination chemistry with a host of metal ions is presented. Structural data for [Zn(TAMEpyr)]2+ show the propensity of the ligand for an …
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Development of a beta-Secretase Activated Prochelator and FRET Probe to Mediate Copper Toxicity in Alzheimer's Disease
… but to date, there are no FDA-approved metal chelators for the treatment of AD. One of the biggest problems with general chelators is their inability to differentiate between the metal ions involved in disease progression verses those involved in normal metabolic function. To address this …
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Investigating the role of sufT in Mycobacterium abscessus using CRISPRi
… conditions and susceptibility to the metal chelator deferoxamine. To this end, 4 sgRNAs were designed, two targeting MAB_2744c (sg2744F1, sg2744F2) and two targeting the upstream gene 2745c (sg2745F1 and sg2745F2) and used to generate 4 M. abscessus sufT knock-down strains (M. abscessus …
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Recombinant Human Betaine -Homocysteine S -Methyltransferase: Discovery as a Zinc Metalloenzyme, and Regulation of Activity by Redox Status
… of 5Cys/Ala are incubated with the Zn chelator, PAR, and the absorbence of the Zn-PAR chelate is monitored, there is no change in absorbence unless methyl-methanethiosulfonate or H2O2 are added, and then the amount of Zn released from the enzyme is equivalent to the amount of 5Cys/Ala …
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