Global ETD Search
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Showing 1 to 12 of 12 for “"chelation therapy"”.
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Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant
… kinase C (PKC) resulting in oxidative stress. Chelation therapy has been a choice to reduce the body burden of lead; however chelation does not eliminate the neurotoxicity of lead...In this study we propose to evaluate the involvement of glutamatergic component in lead-induced toxicity and also …
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Ferrocenic metal chelators : synthesis, biological and electrochemical studies
… urgent alternative treatment for malaria. Iron chelation therapy was considered as a possible approach since iron has been found crucial in the metabolic pathways of P. falciparum. A series of novel iron chelators were designed and synthesized based on thiosemicarbazone and/or ferrocenyl …
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Evaluation of F-18 Labeled Hydroxy Quinoline Derivative as a Potential PET Imaging Agent for Early Detection of Alzheimer’s Disease
… to form metal complexes. The use of metal chelation therapy has emphasized the involvement of metals in the aggregation of plaques and has shown promising results in clinical and animal studies through dissolving plaques and restoring the metals balance in the affected brains. In this …
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Design, synthesis and characterization of new iron and aluminium chelating agents
Chelation therapy is widely used for metal-unbalance related diseases, namely those due to disorders on metal metabolism, such as beta-thalassemia, hemochromatosis (Fe), and neurodegenerative diseases (Cu, Fe, Zn and Al). The study of metal chelators for clinical applications, either as chelating …
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Study of Growth and Bone Mineral Density and Factors Affecting Them in Children and Adolescents With Thalassaemia Major and Sickle Cell Disease
… and manipulate blood and blood products. Iron chelation therapy is an essential part of treatment to avoid or delay the deleterious effects of iron overload on different organs including the liver, heart, pancreas and endocrine glands. This inquires injecting deferoxamine subcutaneously for 12 …
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Development of a beta-Secretase Activated Prochelator and FRET Probe to Mediate Copper Toxicity in Alzheimer's Disease
… as a common thread in disease pathology. </p><p>Chelation therapy has shown some effectiveness in clinical trials, but to date, there are no FDA-approved metal chelators for the treatment of AD. One of the biggest problems with general chelators is their inability to differentiate between the …
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REGULATION AND GOVERNANCE OF ACCESS TO UNPROVEN MEDICAL INTERVENTIONS IN CANADA; A CASE STUDY ANALYSIS
… future strategies. The examples selected were chelation therapy for applications other than treating heavy metal toxicity, liberation therapy for multiple sclerosis, and unproven stem cell interventions. For each case study, a systematic data collection strategy was used that included academic …
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Complex formation equilibria of ligands with metal ions of biomedical interest
… exposure and administration of metallodrugs for therapy or diagnosis, which may cause competition for biometals, generation of oxidative stress and disregulation of several metal-enzyme systems. Inorganic medicinal chemistry has to deal with the introduction of metal ions in the body, but also …
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Prediction of Physicochemical Properties For Fe3+ Chelating Agents
… (3-thalassaemia or sickle cell anaemia, iron chelation therapy is required. Desferioxamine (DFO), the most widely used therapeutic chelator, is a hexadentate ligand possessing a very high affinity for Fe3+, but it is not orally active. 3-hydroxypyridin-4-ones (HPOs), the more recently …
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The design and synthesis of a therapeutic lead-binding agent
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Vacillating between distress and adaptation: a multi-perspective account of lived experiences of thalassemia major
… of fortnightly blood transfusions and daily chelation therapy, imposing major demands on children and their families. Much of the research in the area of paediatric, chronic illnesses such as thalassemia major has investigated psychosocial impact and adjustment to the illness. However, the …
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NANOPARTICELLE A BASE DI CICLODESTRINE PER APPLICAZIONI BIOMEDICALI
Negli ultimi anni lo studio di nuovi macro e nano sistemi ha rappresentato uno degli argomenti di maggior interesse in campo scientifico. L’obiettivo è quello di aumentare l’efficacia della terapia tradizionale soprattutto per la cura di pazienti con malattie croniche, sottoposti a trattamenti per …