Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"checkpoint molecules"”.
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INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS
The crosstalk between the immune system and cancer represents a fundamental aspect of oncology, since a better understanding of disease mechanisms could lead to the development of novel therapeutic strategies. This PhD project focused on three main topics: (1) the expression and prognostic role of …
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Molecular basis of immunotolerance in canine neoplasia
… system is hampered by the expression of immune checkpoint molecules by the cancer cells. In contrast, soft tissue sarcomas are poorly immunogenic, as Tumor infiltrating Lymphocytes are lacking, or when present they are usually at the periphery of the tumor. Still, soft tissue sarcomas are …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
… of immune cells and upregulation of immune checkpoint molecules. Macrophages are the most populous non neoplastic cells in glioblastoma microenvironment, which is a part of the innate immune response and are involved in immune suppression, tumour growth, invasion, and metastasis. The …
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Étude de l’expression et du rôle du ligand du co-stimulateur inductible des cellules T (ICOSL) dans les ostéoclastes humains
… degrade the bone matrix, express costimulatory molecules on their surface, like antigen-presenting cells, which enable them to interact with immune and cancer cells, exerting an immunosuppressive effect on the bone microenvironment. They also maintain a vicious circle with tumor cells by …
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Immune Checkpoint Molecule Expression in Canine Lymphoma and Canine Reactive Lymphoid Hyperplasia
… treatments. Targeted immunotherapy using checkpoint molecule blockade of PD-1 and PD-L1 shows promise for various types of human cancer, including relapsed/refractory lymphoma; however, little is known regarding the role of these checkpoint molecules in canine lymphoma. Objectives: To …
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Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs
… quantified by elevated expression of immune checkpoint molecules, inhibitory factors and reactive oxygen species. Knowing this axis promoted a pro-tumour, suppressive phenotype, we then investigated the consequence of its disruption on tumour growth in vivo. Neutralization of SIRPα on moDCs …
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
… we measured a higher expression of immune checkpoint molecules by CD4+ TSCM and T central memory (TCM) and we measured a higher frequency of T progenitors committed to exhaustion (defined as TSCM and TCM co-expressing PD-1 and TIGIT) in PWHIV with incomplete immune reconstitution. In these …