Global ETD Search
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Showing 1 to 3 of 3 for “"checkpoint adaptation"”.
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Investigation of checkpoint adaptation in human cancer cells treated with the genotoxic agent cisplatin
We investigated checkpoint adaptation in HT-29 colorectal adenocarcinoma cells treated with cisplatin. Cells that undergo checkpoint adaptation arrest at and then abrogate the G2/M checkpoint to enter mitosis with damaged DNA. We identified that cytotoxic amounts of cisplatin induce either …