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Showing 1 to 3 of 3 for “"checkpoint adaptation"”.

  1. Investigation of checkpoint adaptation in human cancer cells treated with the genotoxic agent cisplatin

    We investigated checkpoint adaptation in HT-29 colorectal adenocarcinoma cells treated with cisplatin. Cells that undergo checkpoint adaptation arrest at and then abrogate the G2/M checkpoint to enter mitosis with damaged DNA. We identified that cytotoxic amounts of cisplatin induce either …

    lethbridge Repository record for Investigation of checkpoint adaptation in human cancer cells treated with the genotoxic agent cisplatin (opens in a new tab)

  2. Cancer cells that survive checkpoint adaptation (mitosis with damaged DNA) aquire major chromosomal rearrangements

    lethbridge

  3. Analysis of colon cancer cells that survive checkpoint adaptation after treatment with a genotoxic age

    lethbridge