Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"checkerboard assay"”.
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Use of plant-derived essential oil compounds, naturally-occurring apple aroma compounds, and apple juice flavoring mixtures to control the growth of Escherichia coli O157:H7
… The standard agar dilution method (SAD) and checkerboard assay were used to evaluate the efficacy of the nine compounds, alone and in combination against E. coli O157:H7. In general, the EO compounds were significantly more effective against E. coli O157:H7 than the AA compounds (P<0.05). …
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Novel Inhibitors for Isocitrate Lyase as a Potent Antitubercular Agent for Mycobacterium Tuberculosis
… up crystallisation trials and in vitro enzymatic assay was performed on ICL1 inhibitors. The synthesis of D/L-threo-2-methylisocitrate and the methylation of five other drug candidates were described. Both co-crystallisation and soaking techniques were performed to obtain an ICL1:CL-54-04 complex …
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Optimization of Lead Spectinamide Compounds as Novel Anti-tuberculosis Agents with a Pharmacometric Approach
… The three dimensional surface response assay demonstrated that there is an additive effect between both the agents as opposed to the conventional checkerboard assay, which suggested synergism between these agents. The results of surface response assay were validated using an in vitro …
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Discovery, structural characterisation and targeted engineering of bioactive peptides from amphibian skin secretion
… the common functional domain of Onc112. Synergy checkerboard assay indicated that the hybrid peptide coupling of Onc112 and QUB-1368 contributed to functional improvement instead of cooperation of each fragment. Results indicated that hybrid peptide QUB-2696 exhibited its antimicrobial activity …
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Combinatorial effects of bovicin HC5 and epsilon-polylysine against Alicyclobacillus acidoterrestris in orange juice
… both AMPs in combination was evaluated using the checkerboard assay. A fractional inhibitory concentration (FIC) index of 1 was obtained against the vegetative cells and germinated endospores of A. acidoterrestris DSMZ 2498 indicating an additive effect between the two AMPs. The AMPs alone and in …
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Assessing the acetylcholinesterase inhibitory potential of novel pharmacophores for potential treatment of Alzheimer’s disease
… treatments for AD. An in-house miniaturised AChE assay was used to assess the AChEI activity of 1,453 synthetic compounds from a commercial library (Charles River Laboratory/BioFocus, UK) housed at the Council for Scientific and Industrial Research (CSIR). The selected compounds had been …
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Assay Setup for High Throughput Screening to Identify Novel Efflux Pump Inhibitors against Escherichia coli
Tausta: Maailman terveysjärjestö WHO linjasi vuonna 2014 julkaisemassaan raportissa, että antibioottiresistenssi on todellinen maailmanlaajuinen terveysuhka, jonka vastaiset toimet on käynnistettävä. Uusien antibioottien löytäminen ja kehittäminen Gram-negatiivisten bakteerien aiheuttamiin …