Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"chaos3"”.
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The Fanconi anemia pathway and HELQ work alongside dormant replication origins to suppress replication-associated genome instability
… development. Utilizing the <italic>Mcm4<super>chaos3</super></italic> mouse model, we found that dormant replication origins, which act as backup initiation sites, play a critical role in the recovery of stalled replication forks. A reduced number of dormant origins in these mice led to …
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CHARACTERIZING THE ROLE OF THE CHROMATIN REMODELING COMPONENT ARID1A AS A SUPPRESSOR OF SPORADIC MAMMARY TUMORS IN MICE
… mouse models of this disease. The C3H-MCM4Chaos3(Chaos3) mouse model bears a single endogenous mutation in a gene encoding a component of the MCM2-7 replication helicase, which our lab has previously shown results in a state of chronic replication stress and downstream genomic instability, …