Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cerebrovascular circulation"”.
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Cerebrovascular dysfunction : associations with midlife risk factors
… and structural changes in the brain and cerebrovascular circulation. The rationale for these projects is that continued investigation on the impact of individual and aggregate risk from various cardiovascular risk factors will help target early changes in structure and function that …
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Optimization of the Fair Technique for Specific Brain Region Perfusion Studies
Most of the technical development and applications of ASL (arterial spin labeling) imaging have mainly focused on the superior cortical regions of the brain. However, optimal ASL measurements to quantify cerebral blood flow (CBF) in specific brain regions may require optimized parameters, improved …
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Multiparametric Estimation of Brain Hemodynamics with MR Fingerprinting ASL
… cerebral physiology and clinical application in cerebrovascular diseases. Arterial Spin Labeling (ASL) MRI technique is capable of estimating cerebral blood flow (CBF) without radioactive tracer or contrast agent. However, the signal from ASL is affected by multiple parameters in the kinetic …
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Measurement of Cerebral Metabolism and Vascular Function with Magnetic Resonance Imaging
The brain relies on oxidative metabolism to function properly. Cerebral metabolic rate of oxygen (CMRO2) is thus an important marker for brain health. Existing techniques for quantification of CMRO2 with positron emission tomography (PET) or magnetic resonance imaging (MRI) involve special …
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Measurement of Cerebral Blood Flow Using Arterial Spin Labeling Magnetic Resonance Imaging
Cerebral Blood Flow (CBF) reflects the amount of blood perfusion in the brain, often defined as ml of blood per 100 gram of brain per minute. CBF is an important measure in understanding brain physiology and pathophysiology. Thus, it is important to establish a robust method suitable for …
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Quantitative Non-Contrast Perfusion Measurements Using Arterial Spin Labeled MRI: Evaluation of Therapy Response in Brain Tumors and Technical Advancements in Kidneys
Current radiological criteria, such as the Response Evaluation Criteria in Solid Tumors (RECIST) or the modified Response Assessment in Neuro-Oncology (RANO), primarily focus on measuring tumor size changes for treatment response assessment. However, these conventional techniques may not detect …
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Effects of Aerobic Exercise Training on Carotid Arterial Stiffness and Brain Health in Traumatic Brain Injury
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Interaction between Adrenergic and Nitric Oxide-releasing Nerves in Cerebral Arteries
… arteries with potential to modulate cerebral circulation.</p> <p>This thesis provides evidence supporting the hypothesis that adrenergic and nNOS nerves co-exist within cerebral arteries and strongly suggest an interaction between these two neuron types such that NO released from the nNOS …
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Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular Function, Histopathological and Behavioral Outcomes in Rats
… with reduced cerebral perfusion and impaired cerebrovascular function due, in part, to the generation of reactive oxygen (ROS) and reactive nitrogen species (RNS) (e.g. peroxynitrite, ONOO‾). Although blast TBI (bTBI) also reduces cerebral perfusion, less is known about other cerebral vascular …
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Role of Protein Kinase G in Regulating Vascular Tone in Hypoxic Ovine Cerebral Arteries
<p>Nitric oxide (NO) and its precursors have been used clinically to induce vasorelaxation long before the specific mechanism of how this operates was understood. With the discovery in 1977 of the influence of NO on guanylate cyclase, and the subsequent elucidation of the NO pathway, the role of …
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Postnatal Maturation Modulates Cerebrovascular Myogenic Tone
<p>The present study focused on the main hypothesis that maturation decreases contractile reliance on calcium influx and myofilament Ca2+ sensitivity, and increases reliance on release of calcium from intracellular stores to develop and maintain pressure-evoked myogenic tone in rat cerebral blood …