Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"cerebral perfusion"”.
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Compensation of the Cerebral Perfusion in Patients with Infarction : SPM Analysis
… study was to evaluate the compensatory effect on cerebral perfusion in patients with cerebral infarction. Ninety three Tc-99m ECD brain perfusion SPECTs (male/female: 58/35, mean age 58) of 93 patients with cerebral infarction were evaluated retrospectively. Any patient with bilateral …
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Resting-State Cerebral Perfusion Patterns: An Exploratory Factor Analysis of Single-Photon Emission Computed Tomography Clinical Data
… emission computed tomography (SPECT) regional cerebral blood flow (rCBF) to analyze RS. The omission is critical because SPECT RS networks have a different structure and statistical representation than functional magnetic resonance imaging (fMRI) RS networks. Moreover, recent fMRI research has …
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Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular Function, Histopathological and Behavioral Outcomes in Rats
… non-blast TBI) is often associated with reduced cerebral perfusion and impaired cerebrovascular function due, in part, to the generation of reactive oxygen (ROS) and reactive nitrogen species (RNS) (e.g. peroxynitrite, ONOO‾). Although blast TBI (bTBI) also reduces cerebral perfusion, less is …
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Prospective study to compare the difference in cerebral perfusion in patients undergoing shoulder surgery with the standard beach chair position compared to 30˚ inclination
… angles patients suffered a significant number of cerebral desaturation events that may lead to ischaemic neurological events. This angle is far more upright than what is used in our practice. We postulated that decreasing the angle of inclination may be protective of cerebral perfusion. We …
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Intracranial Monitoring after Severe Traumatic Brain Injury
… physiological insults. In this thesis, I explore cerebral insults due raised intracranial pressure, decreased cerebral perfusion pressure and impaired cerebral pressure reactivity after traumatic brain injury. In chapter 2, the importance of intracranial pressure, cerebral perfusion pressure and …
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Impact of Prolonged Sitting on Cognitive Function: Implications for Cardio-metabolic Risk
… sitting negatively impacts cognitive function, cerebral perfusion, and central cardiovascular hemodynamics; and secondly, to test whether weight or physical activity status alters this response. <strong>Methods:</strong> Participants (N=20, age=26±7; BMI=30±7 kg/m<sup>2</sup>; 7 female) were …
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Predictive utility of neuropsychological measures and single photon emission computed tomography (SPECT) in the classification of cerebral perfusion deficits in dementia of the Alzheimer type (DAT)
… between neuropsychological tests scores and perfusion deficits, based upon measures of regional cerebral blood flow (rCBF) taken from the single photon emission computed tomography (SPECT) scans of patients suffering from dementia of the Alzheimer type (DAT). The study was designed to …
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The Effect Of Body Position On Cerebral Bllod Flow, Cognition, Cardiac Output, Map,and Motor Function In Patients Undergoing Shoulder Surgery : Lateral Versus Beach Chair Position Under General Anesthesia
… <p>The Effect of Body Position on Changes in Cerebral Blood Flow, Cognition, and Motor Function in Patients Undergoing Shoulder Surgery: Lateral versus Beach Chair Position Under General Anesthesia</p> <p> By</p> <p> KELLEY LABONTY</p> <p> December 2013</p> <p>Advisor: Dr. Steven Cala</p> …
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The Effects of Dendro[60]Fullerene on Neurobehavioral Outcome and Cerebral Vascular Function After Traumatic Brain Injury
… in reactive oxygen species (ROS) that leads to cerebral vascular dysfunction. The reduction of ROS can preserve vascular function and lead to improved outcomes. The antioxidant carboxyfullerene nanoparticle, dendro[60]fullerene (DF-1) was examined as a potential therapy for TBI because of its …
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Neurovascular implications of life-long exposure to contact in rugby union; the link to cognition
… extent this relates to an accelerated decline in cerebral perfusion, a major risk factor for cognitive impairment and neurodegeneration remains to be explored.<br/><br/><b>Aims</b>: This thesis sought to: 1) determine the molecular, cerebrovascular and cognitive signatures of professional rugby …
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Cerebral haemodynamics in man: Clinical and applied observations
… oxygenated blood to function normally. Cerebral oxygen delivery is dynamic, and alters rapidly in response to changes in physiological and pathological stimuli. Interference with cerebral oxygen delivery, either as a result of decreased cerebral blood flow, decreased arterial oxygenation …
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NON-INVASIVE MONITORING OF INTRACRANIAL PRESSURE USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY
… (TCD)-based non-invasive methods for ICP and cerebral perfusion pressure (CPP) monitoring. The thesis is divided into three sections: I) The accuracy of existing TCD-based nICP estimators in various scenarios of varying ICP (traumatic brain injury, rise of ICP during plateau waves, and rise in …
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Improving the Robustness of Perfusion Imaging with Arterial Spin Labeling Magnetic Resonance Imaging
Tissue function depends heavily on perfusion, a process which brings the blood supply to the tissue through the arterial system and removes the metabolic by-products via the veins. Abnormalities and disruptions in this process can have profound effects. Cerebral blood flow (CBF), a quantitative …
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Regional Low Cerebral Blood Flow Predicts Leukoaraiosis Development at 18 Months in Patients with TIA and Minor Stroke
… of this study was to investigate whether low cerebral blood flow (CBF) is associated with subsequent white matter hyperintensity (WMH) development in minor stroke and transient ischemic attack (TIA) patients. New WMH at 18 months were identified by comparing follow-up with baseline FLAIR, and …
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Quantifying methodological uncertainties and navigating feasibilities in monitoring of cerebral autoregulation - Towards individualised management of TBI.
… taking advantage of such technologies like cerebral autoregulation (CA) monitoring, has the potential to improve outcomes by tailoring interventions to the unique physiological responses of each patient. However, a significant barrier to the widespread clinical use of CA-based metrics is the …
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Modeling and estimation for non-invasive monitoring of intracranial pressure and cerebrovascular autoregulation
… innate ability of the vasculature to maintain cerebral blood flow in the face of changes in cerebral perfusion pressure. Cerebrovascular autoregulation is often impaired in patients with brain trauma or stroke, and also in pre-term neonates, as their cerebrovascular system is not fully matured. …
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Pressure, Compliance, and Autoregulation Studies in Intracranial Dynamics
… for the physiological relevance of the optimal cerebral perfusion pressure paradigm, CPPopt, and further demonstrated its potential, alongside CPP-oriented therapy, as clinical tools. Two novel indices were developed: UBP, the compensatory reserve upper breakpoint, which may serve as an …
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Impact of secondary insults on the outcome of paediatric traumatic brain injury : a retrospective cross sectional study at the Red Cross Children’s Hospital, Cape Town
… of hypoxia, hypotension, raised ICP, and low cerebral perfusion pressure (CPP). ICP parameters included initial ICP, mean ICP in the first 24 hours, mean ICP overall, peak ICP, mean ICP over 20 mmHg, and episodes of ICP over 20 mmHg. Hypotension was defined by age †and height †adjusted …
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The effect of induced normothermia on the outcomes of severe traumatic brain injury patients at Boston Medical Center
… 0.0001). Average intracranial pressure (ICP) and cerebral perfusion pressure (CPP) were not different between the two groups, although mean arterial pressure (MAP) was (p = 0.84; p = 0.08; p = 0.02, respectively). Mortality was lower in the case group by hospital discharge (p = 0.007) and patients …
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The Measurement and Interpretation of Intracranial Pressure
… matching increases in blood pressure, such that cerebral perfusion pressure remained almost constant. This implied that within a rigid cranium, the cerebral circulation is limited in its ability to expand and accommodate an increase in blood volume. Thus, making blood supply pressure or cerebral …
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