Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"cerebral ischemia"”.
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… toxicity, exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or post-treatment (i.c.v. and i.p.) in a middle cerebral artery occlusion model in mice and decreased neurological deficits induced by …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… an important role in the development of the cerebral lesions [6]. This inflammatory reaction involves activation of resident cells (mainly microglia), infiltration and accumulation of various inflammatory cells (including neutrophils, leukocytes, monocytes, macrophages), and production of …
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Development of SiRNA Incorporated Surface Modified Polymeric Nanoparticle for the Potential Treatment of Global Cerebral Ischemia
Global cerebral ischemia is a cerebrovascular disease caused by cardiac arrest or cardiac surgery. Chronic and excessive neuroinflammation is a major contributor to cell death in the pathophysiology of global ischemia, likely having a detrimental effect on cognitive function. Bromodomain-containing …
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Predictive models of tissue outcome in acute human cerebral ischemia using diffusion and perfusion weighted MRI
… current therapeutic decisions for acute human cerebral ischemia are typically based on time of symptom onset, limiting the number of patients treated. Imaging, however, offers insight into the physiologic integrity of brain tissue that is not attainable with time of symptom onset alone. This …
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The role of dopamine in the striatal cell death produced by transient, global cerebral ischemia in rats
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Ρινική χορήγηση φαρμάκων στη διαχείριση της εγκεφαλικής ισχαιμίας / Nasal drug delivery in the management of cerebral ischemia
Η εγκεφαλική ισχαιμία είναι η κύρια αιτία θανάτου και μόνιμης αναπηρίας στον κόσμο. Είναι εξαιρετικά δύσκολη η αντιμετώπισή της λόγω της ταχείας εξέλιξης της νευρωνικής βλάβης και των περιορισμών των συμβατικών συστημάτων χορήγησης φαρμάκων. Η ρινική χορήγηση φαρμάκων χρησιμοποιείται για την …
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Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia
… statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke. This paper aims to assess the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia. To achieve …
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Role of Cofilin, an Actin Cytoskeletal Protein, in Ischemic Conditions: Potential Therapeutic Target for Ischemic Stroke
Cerebral ischemia or stroke is a condition associated with decreased blood supply to brain leading to death of neurons. It is associated with a diverse cascade of responses involving both degenerative and regenerative mechanisms. Actin cytoskeleton changes play a key role in mediating these …
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Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model
… post-conditioning is crucial for reducing ischemia-related injury. The aim of this study was to assess the effect of isoflurane post-treatment on intracranial hemorrhage and cerebral infarction after tPA treatment for transient cerebral ischemia. Cerebral ischemia was modeled in male …
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Einfluss der Anästhetika Sevofluran und Propofol auf den nekrotischen und den apoptotischen Zelltod nach inkompletter zerebraler Hemisphärenischämie und Reperfusion in der Ratte über einen Beobachtungszeitraum von 28 Tagen
… and apoptotic cell death after incomplete cerebral ischemia and reperfusion in the rat The present study investigates the effect of the anesthetic agents propofol and sevoflurane on irreversible cell damage (necrosis) and programmed cell death (apoptosis) for a time period of 28 days after …
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The Cross-Talk Between Neurons and Microglia Through Interleukin-4 After Ischemic Injury
… propose that this neuronal response to sublethal ischemia is designed to guide surrounding microglia/macrophages to a reparative and anti-inflammatory (M2) phenotype.</p> <p>The research included in this study is designed to establish the mechanisms that underlie neuronal production and secretion …
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An investigation of the neuroprotective properties of fenamate NSAIDs, against experimental model of ischemic stroke
… in understanding the underlying pathogenesis of cerebral ischemia support the involvement of multiple biochemical pathways in the development of the ischemic injury.</p> <p>The work reported in this thesis was undertaken to investigate the hypothesis that fenamate NSAIDs have neuroprotective …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… such as Exendin-4. I showed that global cerebral ischemia was associated with a striking increase in concentration of adenosine triphosphate in the cerebrospinal fluid at 6 hours in near-term fetal sheep. Curiously, the increase in adenosine triphosphate occurred despite no change in the …
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The Total Synthesis of () 7-HDHA
… and related diseases (Alzheimers disease, cerebral ischemia, retina inflammation, etc.), the study of 7-HDHA in relation to PPARs has been hampered by the high cost and limited supply of 7-HDHA. The total synthesis of 7-HDHA was attempted using four different strategies, and finally …
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TREM1-Mediated Neuroinflammation is Critical to Global Ischemia-Induced Neurodegeneration and Cognitive Deficits.
Global cerebral ischemia occurs when blood flow to the entire brain is significantly reduced; this occurs most commonly following cardiac arrest. Following global ischemia, there is delayed and selective loss of neurons in the hippocampal CA1, a critical brain region for learning and memory, …
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Measuring MERCI: exploring data mining techniques for examining surgical outcomes of stroke patients
Mechanical Embolus Removal in Cerebral Ischemia (MERCI) has been supported by medical trials as an improved method of treating ischemic stroke past the safe window of time for administering clot-busting drugs, and was released for medical use in 2004. The importance of analyzing real-world data …
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Glutamate Receptor-Mediated Taurine Release From The Hippocampus During Oxidative Stress
Oxidative stress is an important result of cerebral ischemia and has been directly linked to hippocampal swelling and cytotoxic brain edema in vitro. Swollen brain cells activate volume regulatory mechanisms including a significant efflux of the endogenous sulfonic amino acid taurine via …
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fMRI assessment of ischemic stroke in humans
Cerebral ischemia, or brain ischemia is a kind of stroke where the blood flow is insufficient to the metabolic demand of brain. The lack of oxygen supply will directly lead to the death of brain tissue. There are two major injury regions: the infarct and penumbra. Mostly, since the infarct regions …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
… ETB receptors in the ipsilateral middle cerebral artery (MCA) after experimental focal ischemia and a similar upregulation is also seen after organ culture of MCA. Furthermore, studies have shown an involvement of protein kinase C (PKC) and extracellular signal-regulated kinases (ERK) 1/2 …
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