Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cerebral ischaemia"”.
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Barbiturate treatment in experimental transient focal cerebral ischaemia
… attractive situation of transient focal cerebral ischaemia simulating a cerebral vessel occlusion followed by re-vascularization, had not been specifically investigated with barbiturate treatment. Cerebral infarction is progressive and evolves over hours, proceeding from ischaemia and …
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Cellular Effects of Cerebral Ischaemia In Vitro’. Cerebroprotective Actions of GABAmimetic agents
… more than 80% of all strokes being the result of cerebral ischaemia. There is substantial evidence that during an ischaemic insult extracellular glutamate levels dramatically increase and this increase is strongly implicated in neuronal death. Decreased function of inhibitory mechanisms may also …
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The role of mast cells in a mouse model of focal cerebral ischaemia
… deficiency prior to onset of transient middle cerebral artery occlusion (tMCAo) in rats resulted in a significant reduction in blood brain barrier (BBB) permeability, oedema and neutrophil recruitment. Therefore the hypothesis of this thesis was that mast cells are active in the acute phase of …
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Energy failure following traumatic brain injury: Potential mechanisms and impact of normobaric hyperoxia
Cerebral ischaemia is a frequent finding in post mortem studies following traumatic brain injury (TBI), but clinical studies using 15oxygen positron emission tomography (15O PET) suggest that classical ischaemia is uncommon beyond the first 24 hours after injury. Evidence of metabolic failure in …
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Acute, Low-Grade Inflammation elevates White Matter Sensitivity to Ischaemia
… this can interact with co-morbidities such as cerebral ischaemia, are yet to be examined. This thesis evaluated the response of white matter to acute, low-grade inflammation and the downstream effects this had on its sensitivity to ischaemia. <br/><br/>Here, I used isolated ex vivo white matter …
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Characterising the role of substance P in acute ischaemic stroke.
… applicable stroke therapeutic remains elusive. Cerebral oedema is widely recognised as a common and often fatal complication of stroke that is associated with worsened outcome. However, the exact mechanisms of oedema formation remain unclear, with current therapies largely ineffective in …
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Characterisation of Nrf2-signalling and the effects of boosting astrocytic Nrf2 in a mouse model of ischaemic stroke
… stroke is an ischaemic stroke, the blockage of a cerebral vessel and is causing dementia. Nuclear Factor Erythroid 2 (NFE2)- Related Factor 2 (Nrf2) is a transcription factor and master regulator of a battery of antioxidant and anti-inflammatory genes such as Heme oxygenase-1 (hmox1), NAD(P)H …
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Neural stem cell grafts and the influence of apolipoprotein E in a mouse model of global ischaemia
… of the MHP36 neural stem cell line in a focal ischaemia model, the lipid transport protein apolipoprotein E (apoE) is upregulated and co-localised to differentiated cells in parallel with functional recovery. ApoE has been shown to have a critical role in the response to brain injury and repair …