Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"cerebral hypoperfusion"”.
-
Effects of Sex and Aging in the Response to Global Cerebral Hypoperfusion
… 15- 40% of all dementia cases. Reductions in cerebral blood flow from intracranial and extracranial atherosclerosis increase VCID risk, even in the absence of overt clinical or imaging evidence of stroke/embolization. The pathology seen in patients with chronic cerebral hypoperfusion, such as …
-
Investigating the role of TREM2 and neuroinflammation in an experimental model of chronic cerebral hypoperfusion
Chronic cerebral hypoperfusion resulting from cerebrovascular disease is associated with the development of white matter damage, cognitive impairment and dementia. Although incompletely understood, recent studies suggest neuroinflammation is a key mechanism driving vascular pathology, white matter …
-
Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion
… this hypothesis, cerebrovascular (e.g. chronic cerebral hypoperfusion) and molecular (e.g. APOE, epigenetics) factors might contribute to age-related white matter pathology and cognitive decline. To test this, I used a new mouse model of chronic cerebral hypoperfusion and examined the following …
-
Investigation of inflammatory and oxidative stress mechanisms in the disruption of white matter structure and function following chronic cerebral hypoperfusion
… by cerebrovascular disease and disturbances in cerebral blood flow delivery. It is the second leading form of dementia and vascular factors such as hypertension, diabetes and obesity are associated with an increased risk of developing VCI. White matter alterations are a prominent pathological …
-
Mixed Dementia Induced by Right Common Carotid Artery Occlusion in an Alzheimer Mouse Model
… Alzheimer disease (AD), the effect of chronic cerebral hypoperfusion (CCH) on the progression of AD has not been widely evaluated. We aimed to evaluate whether CCH would aggravate the behavioral changes and plaque formation in an AD transgenic (Tg) mouse model. Female Tg2576 (Tg+) mice (an AD …
-
Magnetic Resonance Imaging of Cerebral Venous Oxygenation
Cerebral venous oxygenation (Yᵥ) is an important biomarker for brain diseases. My dissertation consisted of two studies. The first study aims to investigate the regional Yᵥ in hypertension. Hypertension is known to cause cerebral hypoperfusion and cortical atrophy but its impact on Yᵥ is not yet …
-
Hypertension, blood pressure, cognition and cerebral blood flow in the cohort of "Men born 1914"
… ambulatory blood pressure monitoring, regional cerebral blood flow, and cardiovascular risk factors. It is well known that hypertension plays a major etiological role in the development of cerebrovascular disease, ischemic heart disease, and cardiac failure. High blood pressure has often been …
-
Cerebral blood flow in the non-human primate : an in vivo model and drug interventions
Cerebral blood flow dynamics is an essential component for preserving cerebral integrity. Cerebral blood flow abnormalities are often seen in patients with central nervous system pathologies such as epilepsy, migraine, Alzheimer's Disease, vascular dementia, stroke, and even HIV/AIDS. There is …
-
THE EFFECT OF MELATONIN IN PROTECTING AGAINST THE BEHAVIORAL CONSEQUENCES OF CHRONIC HYPOPERFUSION IN MIDDLE-AGED FEMALE RATS
… occlusion (2VO) procedure in rats, which limits cerebral blood flow (CBF) through bilateral arterial ligation. Therefore, the current study investigated whether chronic melatonin would attenuate 2VO induced behavioral deficits in middle-aged female rats. Thirty 9- to 11-month-old female …