Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 155 for “"cerebral cortex"”.
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Molecular Mechanisms Regulating Fate Determination of Cerebral Cortex Precursors
During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neuronal circuitry, and subsequent matching of glial numbers and position to that circuitry. Multiple molecular mechanisms act in concert to …
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Localization and Function Of RNA Interference in the Cerebral Cortex
… plasticity of the mouse vibrissal barrel cortex. In this model system, chronic whisker plucking reliably leads to the expansion of the cortical representation of the adjacent non-deprived whiskers. The mechanism underlying this process involves changes in synaptic efficacy and sprouting of …
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Anatomical and Physiological Characterization of Striatal Activation of the Cerebral Cortex
… glutamatergic input from nearly all parts of the cerebral cortex, and its output is delivered by direct pathway medium spiny neurons (dMSNs) expressing D1 type dopamine (DA) receptors (D1Rs) and indirect pathway MSNs (iMSNs) expressing D2 DA receptors (D2Rs). Loss of DA results in the imbalance …
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Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice
… experiments, the ultrastructure of the visual cortex was examined in young Fmr1 knockout and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. …
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Clonal architecture and genetic regulation of the developing mammalian cerebral cortex
The mammalian brain is a remarkably intricate organ that starts out as a single layer of epithelial cells. Over the course of development, this single layer of cells grows into many layers of neurons and glia that differentiate into genetically-defined subtypes residing in different regions of the …
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Molecular Mechanisms Controlling the Development and Evolution of the Human Cerebral Cortex
The cerebral cortex is a major integrative centre of the human brain and implements critical functions including sensory processing, motor control, attention, higher cognition, and consciousness. The cortex has expanded during human evolution to contain approximately 16 billion neurons, the highest …
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Dividing the Preplate: Characterization of Neuronal Subpopulations in the Early Murine Cerebral Cortex
… preplate is a transient layer of the developing cerebral cortex which is comprised of the earliest generated cortical neurons. Preplate neurons are a heterogenous population of future Cajal-Retzius neurons and future subplate neurons, which are derived from multiple sources of progenitors. During …
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Spatial and temporal regulation of cerebral cortex development by the transcription factor pax6
Lamina formation in the developing cortex requires precise generation, migration and differentiation of cortical neurons. Cortical projection neurons originate from progenitors of the embryonic dorsal telencephalon. The transcription factor Pax6 is expressed in apical progenitors (APs) throughout …
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Third Harmonic Generation: A Method for Visualizing Myelin in the Murine Cerebral Cortex
… imaging of myelinated axons in the murine cerebral cortex. Myelin plays an important role in the processes of learning and disease. However, much of the myelin biology research thus far has focused on white matter tracts where myelin is more visible. Much is still unknown, particularly with …
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The Role of CNTNAP2 in the Development & Evolution of the Human Cerebral Cortex
… development. Excitatory neurons in the human cerebral cortex have longer neurites and more elaborate neurite branching than chimpanzees or macaques, which is thought to contribute to differences in neural network performance. To study how differences in expression of single genes contributes …
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Anatomical Bases for Auditory Projections to Suprasylvian Visual Areas in the Cat Cerebral Cortex
… were made into defined areas of the cat auditory cortex. Following transport and tissue processing, a light microscope with a digitizing stage was used to visualize and plot labeled auditory projections to the LSS. The results showed that all auditory cortices tested demonstrated projections to a …
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Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
… the development of ASD during human prefrontal cortex development by re-analysing a set of published scRNA-seq datasets. I mainly focused upon two sets of candidate ASD risk genes from the SFARI database, including 86 high confidence ASD risk genes (monogenic mutations in ASD) and 30 genes at …
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Exploring the functional organization of cerebral cortex using data from the Human Connectome Project
… window to look at the macroscale organization of cerebral cortex. Despite monumental efforts to map the structure and function of cerebral cortex, our understanding has been limited due to insufficient sample sizes, low-resolution imaging, and suboptimal volume-based analyses. In recent years, the …
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Quantifying Dyrk1a During Perinatal Development in the Hippocampus, Cerebral Cortex and Cerebellum of the Ts65Dn
The relationship between gene copy number and protein expression levels has not thoroughly been examined in humans or mouse models of Down syndrome (DS) in relationship to developmental changes in the trisomic brain. Found on human chromosome 21 (Hsa21) and triplicated in DS, Dual-specificity …
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THE CHARACTERIZATION AND REGULATION OF BENZODIAZEPINE BINDING SITES IN THE MAMMALIAN RETINA, CEREBRAL CORTEX AND KIDNEY
… retina and it has all the characteristics of cerebral [³H]FLU binding. Monosodium glutamate (MSG) is toxic to retinal neurons and it was used to ascertain the putative cellular localization of retinal BZD binding sites. Nine weeks following neonatal MSG administration, histologic evidence …
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Learning task-optimal image registration with applications in localizing structure and function in the cerebral cortex
… demonstrate improvements in parcellation of the cerebral cortex into different structural units. In this thesis, we work with spherical representations of the human cerebral cortex. Consequently, we develop a fast algorithm for registering spherical images. Application to the cortex shows that …
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Differences in female and male development of the human cerebral cortex from birth to age 16
This study compares the development of the human cerebral cortex of 224 girls and 284 boys in a series of cross-sectional analyses as measured by EEG coherence on normal children's brains (longisectional design). Correlations of these EEG readings taken from all brain regions between a mean age of …
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