Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"cerebral autoregulation"”.
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Mechanisms of Cerebral Autoregulation in Traumatic Brain Injury
… into the characterisation and dynamics of cerebral autoregulatory (CA) impairment has vastly improved understanding of this detrimental secondary injury process in traumatic brain injury (TBI), there are still unknowns before we can target autoregulatory disturbance in the neurocritical …
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Optimization of the assessment of cerebral autoregulation in neurocritical care unit
Introduction Cerebral autoregulation (CA) refers to the physiological mechanisms in the brain to maintain constant blood flow despite changes in cerebral perfusion pressure (CPP). It plays an important protective role against the danger of ischaemia or oedema of the brain. Over the years, various …
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The Baroreflex And Neurogenic Control Of Cerebral Autoregulation In Cerebral Blood Flow
Introduction The neurogenic component of cerebral autoregulation (CA) refers to those mechanisms controlling cerebral blood flow under the influence of the nervous system, and which rely on the innervation of the cerebral blood vessels. The neurogenic control of CA is incompletely understood. …
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EVALUATION OF CEREBRAL AUTOREGULATION: FROM THE TRADITIONAL PRESSURE-FLOW INDEXES TO A DIRECTIONAL MULTIVARIATE ANALYSIS
… una stretta regolazione del flusso ematico cerebrale e, di conseguenza, un adeguato apporto di ossigeno al cervello. Il sistema cerebrovascolare funziona in modo bidirezionale: la pressione arteriosa media (MAP) determina cambiamenti nella velocità media del flusso sanguigno cerebrale …
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Quantifying methodological uncertainties and navigating feasibilities in monitoring of cerebral autoregulation - Towards individualised management of TBI.
… taking advantage of such technologies like cerebral autoregulation (CA) monitoring, has the potential to improve outcomes by tailoring interventions to the unique physiological responses of each patient. However, a significant barrier to the widespread clinical use of CA-based metrics is the …
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The impact of ischaemic preconditioning on cerebrovascular function in healthy individuals.
… studies have examined the impact of RIPC on cerebral blood flow (CBF) or cerebrovascular function. The overall aim of this thesis was to assess, in healthy individuals, the impact of bilateral arm RIPC or SHAM on resting CBF, cerebrovascular reactivity, cerebral autoregulation, and …
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Cerebral autoregulation in children with traumatic brain injury: Comparing the autoregulatory index (ARI) to pressure reactivity index (PRx) and their associations with cerebral physiological parameters
As an important hemodynamic mechanism, pressure autoregulation protects the brain against inappropriate fluctuations in cerebral blood flow subject to changing cerebral perfusion pressures. In acute neurological illnesses, including traumatic brain injury in children, impaired autoregulation is …
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The BOLD MRI response of the brain to alterations in arterial blood pressure
The impact of blood pressure changes on cerebral blood flow is an important area of investigation. The cerebral autoregulation mechanism acts to maintain blood supply to the brain, despite changes in blood pressure. Blood flow alterations are closely linked to neuronal activation, and this activity …
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Assessment of control and performance of biomedical systems
… control; (ii) the second an application concerns cerebral autoregulation (a stable cerebral blood flow over a range of arterial blood pressure), to maintain patient safety during a surgical procedure to prevent stroke. Repeated measurements of cerebral blood flow and arterial blood pressure were …
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Continuous Multi-Modal Monitoring of Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Impaired cerebral autoregulation following traumatic brain injury (TBI) in adults has been linked to worse global outcome. Continuously updating indices of cerebrovascular reactivity provide a convenient and continuous metric regarding an individual patients’ autoregulatory status. To date, the …
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Do abnormalities in dynamic cerebral auto-regulation underlie the pathophysiological processes behind syncope in older people?
Do abnormalities in dynamic cerebral auto-regulation underlie the pathophysiological processes behind syncope in older people? Introduction: The aim of this thesis was to investigate whether abnormalities in dynamic cerebral auto-regulation (dCA) explain the symptoms associated with orthostatic …
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Predicting adverse neurological outcomes in infants receiving therapeutic hypothermia for hypoxic ischemic encephalopathy
… Near-infrared spectroscopy (NIRS) measures of cerebral regional oxygenation (rSO2) is a growing area of interest for prognostication. Objective: The objective of this study is to determine if changes in rSO2 measured via NIRS during TH are associated with brain injury or neurodevelopmental …
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Peripheral and Cerebrovascular Function during the Female Lifespan
… important events in the female life course on cerebral and peripheral vascular risk is largely unknown and developing an understanding of such vascular responses is necessary. Importantly, exercise training has known benefits on cerebral and peripheral vascular function, however the role of …
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Investigating cerebrovascular pressure reactivity in a large cohort of children with severe traumatic brain injury
… in developing resource-scarce countries. Cerebral autoregulation (CA) is a homeostatic mechanism that aims to maintain constant cerebral blood flow within a range of systemic blood pressures, and the loss of this mechanism has been associated with mortality and worse outcomes in adult TBI. …
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Effects of Tea on Peripheral and Cerebral Micro- and Macrovascular Function in Humans
… the impact of tea ingestion on peripheral and cerebral micro- and macrovascular function in humans. In an initial methodological study, the day-to-day reproducibility of thermally stimulated cutaneous microvascular function was assessed. Fifteen, healthy males (28 ± 5 yrs, BMI 25 ± 2 kg/m2) …
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Mathematical Modelling of Brain Haemodynamics and Pressure-Volume Compensation
… model representing the circulation of cerebral fluids to investigate the relationships between intracranial pressure (ICP) and cerebral blood volume (CBV) changes. The effects of these relationships on the performance of indices describing vascular dynamics were also examined. The …
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The effects of sitting on cerebrovascular and cognitive function
… of SB on cerebrovascular function, comprising cerebral blood flow (CBF), cerebral autoregulation (CA) and cerebrovascular carbon dioxide reactivity (CVR). This is of upmost importance since the maintenance of cerebrovascular function appears critical for cognition, mood and the prevention of …
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Novel Interventions to Improve Cerebral and Peripheral Vascular Function
… blood vessels that supply brain. Impairments to cerebral blood flow (CBF) and cerebrovascular function result in increased risk of cognitive impairment, vascular dementia and stroke. Identifying interventions that can attenuate the age-related decline in CBF and enhance cerebrovascular function …
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The Effect Of Body Position On Cerebral Bllod Flow, Cognition, Cardiac Output, Map,and Motor Function In Patients Undergoing Shoulder Surgery : Lateral Versus Beach Chair Position Under General Anesthesia
… <p>The Effect of Body Position on Changes in Cerebral Blood Flow, Cognition, and Motor Function in Patients Undergoing Shoulder Surgery: Lateral versus Beach Chair Position Under General Anesthesia</p> <p> By</p> <p> KELLEY LABONTY</p> <p> December 2013</p> <p>Advisor: Dr. Steven Cala</p> …
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The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… flow [VA<sub>Q</sub>]) and intracranial (middle cerebral artery blood velocity [MCA<sub>V</sub>] and posterior cerebral artery [PCA<sub>V</sub>]) haemodynamics. Global cerebral blood flow (gCBF) was calculated and used to quantity global cerebral substrate delivery of oxygen (gCDO<sub>2</sub>) …
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