Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"cerebral atrophy"”.
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Genetic determinants underlying rare diseases identified using next-generation sequencing technologies
… obesity, and families with brachydactyly, cerebral atrophy, microcephaly-ichthyosis, and widow’s peak syndrome. Understanding these variants and their contribution to disease can increase understanding of disease mechanisms and help with the development of therapeutic interventions in the …
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The Impact of Gamma Stimulation on Neurological Phenotypes of Alzheimer's Dementia and Down Syndrome
… such as amyloid and tau levels, prevented cerebral atrophy, and improved behavioral testing performance in mouse models of AD. This thesis work focuses on the translation of this intervention into human patients with AD. Initial pilot studies assessed safety, compliance, entrainment and …
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Mechanisms of Translational Control
… levels and cause progressive cerebello-cerebral atrophy (PCCA) in humans. We conducted detailed biochemical, functional, and structural analyses of 12 pathogenic SEPSECS variants. Our results provide an improved framework for understanding SEPSECS-related neurodegeneration and may aid in …
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Étude des liens entre les mesures quantitatives de la vascularisation cérébrale, les fonctions cognitives et la neuropathologie dans la maladie d’Alzheimer
… between 1) the diameters of the posterior cerebral arteries, 2nd segment (ACP2) and of the anterior choroidal arteries (AchA) and the Clinical Dementia Rating Scale – Sum of Boxes (CDR-SB) and 2) the diameters and the volumes of cerebral arteries and i) cognition; ii) AD neuropathology, …
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Intracranial hypertension in Kenyan children with cerebral malaria
Cerebral malaria is a common encephalopathy in African children, but the cause of death and neurological sequelae are unknown. This dissertation examines the hypothesis that raised intracranial pressure (ICP) is a determinant of poor outcome in Kenyan children with cerebral malaria. The opening …
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Targeting TNFSF10 as a novel immunotherapeutic strategy in Alzheimer’s disease
… extreme unmet needs and a huge disease burden. Cerebral atrophy, amyloid plaques, and neurofibrillary tangles represent the main pathological characteristics of the AD brain. Despite remarkable research efforts to unravel pathophysiological mechanisms of AD, a disease-modifying therapeutic …
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Aging and Weight-Ratio Estimation
<p>Many researchers have explored the way younger people perceive weight ratios using a variety of methodologies; however, very few researchers have used a more direct ratio estimation procedure, in which participants estimate an actual ratio between two or more weights. Of the few researchers who …