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Showing 1 to 16 of 16 for “"cerebral amyloid angiopathy"”.
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Cerebral Amyloid Angiopathy and Transition Metals in Alzheimer's Disease
… to Alzheimer's disease-related iron overload. Cerebral amyloid angiopathy (CAA) is a vascular manifestation of Alzheimer's disease present to some degree in up to 95% of Alzheimer's disease patients. This vasculopathy results in vascular inflammation and fragility which produces clinically …
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Microglia and Complement in Alzheimer's Disease with Cerebral Amyloid Angiopathy
… with its genotypic and phenotypic heterogeneity. Cerebral amyloid angiopathy (CAA) is a common, yet frequently overlooked, pathology associated with AD. A pathological hallmark of AD consists of extracellular amyloid-beta (Aβ) deposits, while CAA</p> <p>manifests with deposition Aβ within the …
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The Role of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy
<p>In healthy brain tissue, toxic amyloid-β (Aβ) proteins are transported by the pulsatile flow of cerebrospinal fluid (CSF) along perivascular drainage pathways. Ischemic stroke may disrupt this process, leading to a perivascular build-up of Aβ, termed cerebral amyloid angiopathy (CAA). I …
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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System
<p>Cerebral amyloid angiopathy (CAA), where beta-amyloid (Aβ) deposits around cerebral blood vessels, is a major contributor of vascular dysfunction in Alzheimer's disease (AD) patients. However, the molecular mechanism underlying CAA formation and CAA-induced cerebrovascular pathologies, including …
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Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia
… hallmarks of Alzheimer's disease, deposition of amyloid protein in the cerebrovasculature (cerebral amyloid angiopathy), is surprisingly common in vascular dementia, and frequently more severe than in Alzheimer's disease. In Alzheimer's disease, cerebral amyloid angiopathy is associated with …
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Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change
Cerebral amyloid angiopathy (CAA) refers to the deposition of Abeta (Aβ) peptides in the brains small blood vessels leading to hemorrhagic stroke and cognitive impairment. Aβ is toxic to smooth muscle cells and impairs blood flow regulation. Reduced blood oxygen level dependent (BOLD) signal …
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The role of cerebral small vessel disease in dementia
Introduction: Cerebral small vessel disease (SVD) is increasingly recognised as a key factor in dementia and cognitive impairment, although its role in the pathogenesis of Alzheimer’s disease (AD) remains poorly understood. Through the investigation of how SVD relates and interacts with (1) …
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Cerebrovascular and Neuronal Cellular Consequences of Amyloid-β Induced Nuclear Factor-κB Activation
… extracellular plaques are composed of aggregated amyloid-β protein (Aβ), which is widely believed to be the underlying cause of the disease. Mounting evidence suggests the small, soluble aggregates of Aβ induce the progressive neurodegeneration observed in AD patients. AD patients also display …
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Microfabrication Approaches for Understanding the Role of Vascular Mechanics in Progressive Diseases
… especially in progressive diseases of the cerebral vessels. With the growing prevelance of blast traumatic brain injury in modern warfare, never before has investigation of cerebral vascular disease been more pertinent. Here, we focus on the development of microfabrication experimental …
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Quantification of Localized Brain Iron Sources Using Magnetic Resonance Phase
… bleeds, and 4) with actual BMB in postmortem cerebral amyloid angiopathy brain. Measurements of geometric features in phase images were related to source iron content and diameter using mathematical models. Iron samples and BMB lesions were assayed for iron content using atomic absorption …
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The Clinical Determinants of Plasma β-amyloid and Its Association with Structural and Functional Vascular Changes
<b>Background</b>: β-amyloid plaque deposition is a pathological hallmark of Alzheimer’s disease and cerebral amyloid angiopathy. However, β-amyloid has also been shown to possess direct vasoactive properties and increased plasma β-amyloid has been associated with endothelial dysfunction in …
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Multi-modality imaging assessment of cerebral small vessel disease biomarkers after stroke due to spontaneous intracerebral haemorrhage
In most cases, spontaneous intracerebral haemorrhage (ICH) is thought to result from cerebral small vessel diseases (SVDs). Cerebral amyloid angiopathy (CAA) and arteriolosclerosis (non-CAA SVD) are the two main types of SVD associated with ICH. The risk of recurrent ICH and post-stroke dementia …
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Gender differences in risk of neuropathology, cognitive decline and dementia in the Cognitive Function and Ageing Study (CFAS)
… of pathologies: primarily ADNC pathologies and cerebral amyloid angiopathy (CAA), but also other neurodegenerative pathologies and some vascular pathologies. Interaction tests found no differences between genders. APOE ε2, by contrast, had a protective effect against ADNC pathologies, …
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Blood pressure variability and the characteristics and outcomes of patients with intracerebral haemorrhage
… modifiable risk factor for spontaneous intracerebral haemorrhage (ICH). International guidelines about the management of high BP for primary prevention of cardiovascular disease and secondary prevention after stroke refer to mean or 'usual' BP targets for office BP monitoring (long-term …
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Investigation of amyloid-β aggregates derived from light-triggered nitration: relevance for Alzheimer’s disease [Indagine sugli aggregati di amiloide-β derivanti dalla nitrazione indotta dalla luce: rilevanza per la malattia di Alzheimer]
… classic-core, coarse-grained e angiopatia cerebrale amiloide. La nitrazione ha mostrato una netta predominanza nei depositi vascolari di Aβ e nelle placche coarse-grained, supportando un ruolo della nitrazione come marcatore tardivo di neuroinfiammazione e coinvolgimento vascolare. Nel …
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The Effect of Grapes in Mice with Alzheimer's Disease and Brain Injury
… in cognitive and memory deficits and deposits of amyloid beta (Aβ) in the cortex and hippocampus are thought to be significant contributors to the disease process. Increasing evidence suggests that foods rich in polyphenols, such as pomegranates and grapes, may have neuroprotective effects in both …