Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"cerebellar granule cells"”.
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The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… mutant mouse (naked-ataxia, nax) shows severe cerebellar cortex defect with a significant reduction in granule cells in the cerebellum. The sonic hedgehog (SHH) and N-Myc pathways are important for granule cell precursor proliferation and differentiation. The project tests the hypothesis that …
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Ena/VASP proteins regulate vertebrate nervous system development : a thesis presented
… the motility and morphology of a variety of cells. I have investigated the in vivo requirement for the vertebrate family members, Mena and VASP in nervous system development. I show that Mena and VASP are required for viability and the formation of the neural tube, spinal nerves and several …
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Spatial-Temporal Regulation of the Atonal Homolog 1 Gene
… is necessary for the correct development of the cerebellar granule cells, the dorsal interneuron 1 population, gut goblet cells and the cochlear and vestibular hair cells of mice. The purpose of these studies was to determine how atonal homolog 1 is regulated by analyzing the activity of atonal …
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ZIPRO1: Fine Tuning Proliferation in Discrete Cell Populations
… of expression in several tissues. The main cells expressing Zipro1 are proliferating cells from epidermal lineages. This includes the cerebellar granule cells (GCs), nasal epithelia and dermal papilla. Through gene dosage experiments we have shown that Zipro1 is involved in proliferation …
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PLASMA MEMBRANE ASSOCIATED GLYCOHYDROLASES: KINETICS PARAMETER CHARACTERIZATION AND BIOLOGICAL FUNCTION
… to study these PM associated activities in rat cerebellar granule cells along differentiation and aging in culture. We started to characterize the kinetic parameters of these enzymes working directly on the external leaflet of the PM in living cells: first of all, we performed an assay using …
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Effetto dell’etanolo sullo stato di metilazione del gene che codifica per la neurotrofina “Brain-Derived Neurotrophic Factor”
… expression, both “in vivo” and “in vitro”. Rat cerebellar granule cells in culture were exposed to acute ethanol, chronic ethanol or ethanol withdrawal. Our results demonstrate that ethanol exposure increases, the abundance of BDNF exon IX transcript in the three different treatment conditions. …