Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cerebellar development"”.
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Mining the Medulloblastoma Genome and Transcriptome
… shed light on the establishment of the normal cerebellar cytoarchitecture, identifying a physiological glutamate gradient with critical implications to both cerebellar development and disease. This thesis stresses the importance of interrogating medulloblastoma in a subgroup-specific manner. …
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Ontogenetic and comparative aspects of cerebellar and motor development
During the course of development the motor repertoire of animals and humans alike go through dramatic changes. New motor patterns arise; movements become coordinated, improve in precision and are at the same time continuously calibrated to the changing body dimensions. The cerebellum is critical …
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Role of Reelin-Dab1 Signaling in the Neuritogenesis
… and positioning of neuronal cell during brain development. It also reported that Reelin-deficient mice (reeler) showed a significant decrease in neurite formation and this depression was rescued by Reelin treatment. The neuritogenesis has been known to be promoted by the activation of Gαi/o …
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The Role of Microglia and Astrocyte in Spinocerebellar Ataxia Type 1
Spinocerebellar ataxia type 1 (SCA1) is a fatal dominantly inherited neurodegenerative disease. Even though there has been illuminating work on the effect of the disease-causing protein, a polyQ expanded ATAXIN-1 (ATXN1) on neurons, the relative contribution to disease of glia has been unknown. …
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Alterations in cerebellar protein synthesis in propylthiouracil-induced hypothyroid rats
… role in the regulation of gene expression and cerebellar development in the rat. The drug propylthiouracil was used to disrupt thyroid hormone synthesis. This permitted investigation of gene expression under three different states of hormonal deprivation: early in development (PTU 1), late in …
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Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
During brain development, reelin, an extracellular matrix protein regulates neuronal migration in the cerebral cortex, hippocampus, cerebellum and many other regions of mammalian brain. In the cortex, reelin is secreted by cajal-Retzius cells in the developing marginal zone and is required for …
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Regulation of Cerebellar Purkinje Cell Development: Interactions Between Trophic Factors and Neurotransmitters
… during late embryonic and early postnatal development, suggesting that NGF may play an important role in cerebellar ontogeny. However, while receptor had been localized to some cerebellar populations, delineation of receptor subtypes, and potential physiologic function remained to the …
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Dissecting the role of AUTS2 and GALNT17 in neurodevelopment using a mouse model for human AUTS2 syndrome
… including intellectual disability (ID), developmental delay, feeding difficulties, epilepsy, microcephaly, and craniofacial abnormalities. Moreover, the severity of each of these phenotypes in individual ASD patients varies dramatically, because most ASD cases are multigenic, involving …
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THE EVOLUTION OF THE MODERN CONDITION THROUGH THE LENS OF NEURODEVELOPMENT DIVERSITY: INSIGHTS FROM A PARADIGMATIC REWIRING OF GENE REGULATION
… how regulatory changes reconfigured the neurodevelopmental trajectories that underpin hallmark features of our species’ unique cognitive abilities requires the integration of computational and experimental approaches, pairing top-down genome-scale prediction with bottom-up mechanistic …