Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"cerebellar cortex"”.
-
High frequency field potentials of the cerebellar cortex
… ganglia and the motor areas of the cerebral cortex. Both somatosensory and the cerebro-cerebral pathways bring in massive amounts of neural information to the cerebellum. The output of the cerebellar cortex projects to various motor cortices as well as down to the spinal cord to make its …
-
An Associative Memory Trace in the Cerebellar Cortex
… it was proposed that Purkinje cells in the cerebellar cortex learn to associate the neutral conditioned stimulus with the response. Since their work, several studies have provided data that are consistent with this suggestion, but definitive evidence has been lacking. Information on how …
-
Does cerebellar cortex function as a forward internal model for motor control?
… investigated whether the firing discharge from cerebellar neurons is consistent with the output of a forward internal model. To specifically evaluate the simple spike firing from Purkinje cells in lobules IV-VI, we trained rhesus macaques to perform different hand movement tasks using a 2 joint …
-
Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
… regulates neuronal migration in the cerebral cortex, hippocampus, cerebellum and many other regions of mammalian brain. In the cortex, reelin is secreted by cajal-Retzius cells in the developing marginal zone and is required for inside-out layering of neurons in the cortical plate. Reelin …
-
The effects of concurrent timed-interval finger tapping on trace eyeblink conditioning in college students
… experiment is to investigate the involvement of cerebellar cortex in trace eyeblink conditioning by utilizing the traditional dual-task design. Timed-interval finger tapping, a motor function mediated by the cerebellar cortex, and several different cognitive tasks representing dissociable …
-
A Map of Transcription Factor Expression in Neuronal Precursors of the Chicken and Mouse Embryonic Cerebellum
… overlying cortical structure and a basal set of cerebellar nuclei (CN). The cerebellar cortex contains two principal neurons, the Purkinje cell (PC) and the granule cell (GC), whereas the CN are formed by an heterogeneous array of cerebellar nuclei neurons. Although granule cell development is …
-
Development of a tool for automatic segmentation of the cerebellum in MR images of children
The human cerebellar cortex is a highly foliated structure that supports both motor and complex cognitive functions in humans. Magnetic Resonance Imaging (MRI) is commonly used to explore structural alterations in patients with psychiatric and neurological diseases. The ability to detect regional …
-
Roles Of Inhibitory Interneurons In Cerebellar Cortical Processing For Oculomotor Control
The cerebellar cortex is usually offered up as the prime example of a well-worked out circuit; indeed, its basic neuronal composition and organization has been known for over one hundred years. Yet mysteries still abound about the computations that are performed within its layers, and how these …
-
Surface recordings of evoked field potentials from the cerebellum with a flexmea microelectrode array
… control. There are two input pathways to the cerebellar cortex, the mossy fiber and the climbing fiber pathways. The mossy fiber pathway forms a disynaptic input to Purkinje cells through the granular cells. This disynaptic input produces a multicomponent field potential composed of the P1, N …
-
Computational studies of cerebellar cortical circuitry
… Ca2+ channelopathy on the physiology of the cerebellar cortex in tottering mice and to explore the mechanisms that transform homeostatic deficits due to genetic mutations into transient phenotype such as episodic dystonia. Understanding the cerebellum function is an ongoing challenge. The …
-
Tissue Parameter Mapping in Children with Fetal Alcohol Spectrum Disorders
… T1 differences were found in the caudate, cerebellar cortex, hippocampus, accumbens, putamen, choroid plexus, ventral diencephalon (DC), right vessel and ventricles. Significant T2 differences were found in the caudate, brain stem, corpus callosum (CC), amygdala, cerebral cortex, choroid …
-
The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… mutant mouse (naked-ataxia, nax) shows severe cerebellar cortex defect with a significant reduction in granule cells in the cerebellum. The sonic hedgehog (SHH) and N-Myc pathways are important for granule cell precursor proliferation and differentiation. The project tests the hypothesis that …
-
Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… (PNs) are the sole GABAergic output from the cerebellar cortex and receive major excitatory inputs via parallel fibers (PFs) that produce high levels of nitric oxide (NO) via neuronal nitric oxide synthase (nNOS). Previous studies demonstrate that nNOS/NO signaling is crucial for PF-PN …
-
Investigating Cerebellar Mechanisms of Schizophrenia by Using a Pharmacological Mouse Model: Regulation of Voltage-Gated Potassium Channels
… channels Kv2.1, Kv6.4, and Kv3.1b in the cerebellar cortex of a phencyclidine-induced mouse model of schizophrenia and explores their potential role in schizophrenia symptoms. In Chapter 3 we show using immunohistochemistry that Kv2.1 is expressed in the Purkinje cells and granule cells as …
-
Monitoring of cerebellar injury using micro ECoG signals in ketamine/xylazine treated rats
Much of the cerebellar research has been conducted in anesthetized animals, particularly using ketamine/xylazine combination in rats, and yet the absolute impact of the anesthesia on the neural circuit remains unanswered . In the current study, spontaneous electrical activity and sensory evoked …
-
An investigation of the integrity of two components of the cerebellar neurocircuitry involved in classical eyeblink conditioning in children prenatally exposed to alcohol: a magnetic resonance spectroscopy and functional magnetic resonance imaging study
… (FASD) (Jacobson et al., 2008). The deep cerebellar nuclei and cerebellar cortex are critical elements of the cerebellar-brainstem circuitry that mediates EBC (Green et al., 2002a; Yeo and Hardiman, 1992; Perret et al., 1993). In this study, we used magnetic resonance spectroscopy (MRS) …
-
Neuroimaging investigation of the motor control disorder, dystonia with special emphasis on laryngeal dystonia
… requiring more precision. Results suggest that cerebellar cortex is recruited particularly during fine motor control.
-
Understanding the Mechanisms of Motor Learning in the Vestibulo-ocular Reflex
… in the VOR gain is initially encoded within the cerebellar flocculus. Furthermore, these learned gain changes can be disrupted or consolidated into a long-term memory. In this thesis we describe novel results that show that consolidation of the VOR can take place rapidly, within 1 hour after …
-
The role of gene expression and aging in SCA1
Spinocerebellar ataxia type 1 is an autosomal dominant disorder caused by a CAG repeat expansion encoding a polyglutamine tract, where patients present with a lack of motor coordination including ataxia. The disease is characterized pathologically by loss of Purkinje cells (PCs) in the cerebellar …
-
Computational Methods and Analyses for Assessing Cerebellar Electrophysiology with Magneto- and Electroencephalography
… cognitive, and emotional functions. Cerebellar dysfunction has furthermore been implicated in some of the most prevalent neuropsychiatric diseases including autism and schizophrenia, with new information implicating the cerebellum in neurodegenerative dementias and Parkinson's disease …
Page 1 of 2