Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"ceramide"”.
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Ceramide-Induced Alternative Translocation of TM4SF20
… drug, doxorubicin, and the sphingolipid, ceramide. Additionally, TGF-β (transforming growth factor-β), a cytokine known to stimulate collagen production, induces the proteolytic activation of CREB3L1 in human A549 cells through inhibition of TM4SF20 expression, which normally inhibits RIP …
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Characterization of ceramide synthases (Cers) in mammalian cells
This thesis describes the characterization of ceramide (Cer) biosynthesis by mammalian cells. The possibility that Cer undergo developmental changes was explored using mouse embryonic stem cells versus embryoid bodies by analysis of the Cer subspecies by liquid chromatography, electrospray …
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The isolation of Ceramide trihexosidases from normal plasma
Thesis (M.S.)--Michigan State University. Dept. of Biochemistry, 1975
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Role of the sphingomyelin/ceramide pathway in diabetic retinopathy
Thesis (Ph. D.)--Michigan State University. Department of Microbiology and Molecular Genetics, 2010
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Structural Basis for the Regulation of the Ceramide Transfer Protein
Ceramide, a central intermediate in sphingolipid metabolism, is synthesized at the endoplasmic reticulum (ER) and transferred to the Golgi by the ceramide transfer (CERT) protein for conversion to sphingomyelin (SM). CERT is a multi-domain protein that contains an amino terminal pleckstrin homology …
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The regulation of ceramide content and insulin resistance in skeletal muscle
… palmitic acid causes insulin resistance and how ceramide content is regulated under the various conditions in the isolated rat soleus muscle. A submaximal insulin stimulus (100 ,aU/ml) increased 3-O-methylglucose transport by -2.7 fold over basal conditions in the soleus (1.90 ± 0.23 …
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Ceramide Accumulation in the Alpha Cell Drives Glucagon Secretion and Hyperglycemia
… transferase, the rate limiting enzyme in ceramide synthesis, in islets of obese fa/fa ZDF rats compared to lean mice of the same age (2). Blockade of ceramide synthesis in these islets demonstrated a decrease in lipid mediated apoptosis. Further studies have shown that aberrant deposition …
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The Middle Region is Required for Phosphorylation Regulation of Ceramide Transfer Protein
The trafficking of ceramide from endoplasmic reticulum (ER), where it is synthesized, to the Golgi for sphingomyelin synthesis is mediated by the ceramide transfer protein (CERT) in a nonvesicular fashion. CERT is a cytosolic protein containing multiple domains and motifs. The START (steroidogenic …
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Role of Ceramide Accumulation in the Ventromedial Hypothalamus in Driving Systemic Metabolic Impairments During Obesity
… during obesity. One of these lipotoxic lipids is ceramide, a sphingolipid. Ceramides have been demonstrated to blunt insulin sensitivity and contribute to numerous obesity-related impairments of tissue function, as seen in vascular endothelium, pancreatic islets, heart failure, and muscle, liver, …
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Role of Ceramide-1-Phosphate as a Specific and Potent Activator of Group IVA Cytosolic Phospholipase A2 Alpha
… by the emerging bioactive sphingolipid, ceramide-1-phosphate (C1P). In this study, we have developed a modified Triton X-100/phosphatidylcholine (PC) mixed micelle assay which was utilized to determine the kinetics and specificity of this lipid-enzyme interaction. Using this assay, the …
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Ceramidsynthese in Saccharomyces cerevisiae
… is not due to lacking phosphoinositolation of ceramide, since the catalytic activity of the corresponding enzyme was proven in vivo.(v) The synthesis block in lag1Ddgt1D cells leads to an accumulation of sphingoid bases. In this connection it was shown, that Lag1p and Dgt1p are essential for …
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The role of ceramides in cigarette smoke-induced alveolar cell death
… apoptosis is not known. We hypothesized that ceramides are induced by CS via specific enzymatic pathways that can be manipulated to reduce lung cell apoptosis. CS increased ceramides in the whole lung and in cultured primary structural lung cells. Exposure to CS activated within minutes the …
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BIOPHYSICAL STUDIES OF THE MECHANISM OF CERAMIDE CHANNEL DESTABLIZATION BY BCL-XL IN APOPTOSIS AND THE USE OF RECTIFICATION TO PROBE THE STRUCTURE AND DYNAMICS OF A NOVEL ESCHERICHIA COLI CHANNEL
Ceramide forms a novel type of channel in the mitochondrial outer membrane and these channels are involved the release of intermembrane space proteins from mitochondria, a decision-making step in the apoptotic process. An antiapoptotic protein, Bcl-xL, regulates the apoptotic process and inhibits …
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Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… in myoblasts is mediated by activation of ceramide generating pathways, including N-SMase, A-SMase and de novo ceramide synthesis. The blockers of all three pathways suppress the ability of TNFalpha and IL-1beta to inhibit IGF-I-induced protein synthesis and expression of myogenic …
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The Group IVA Cytosolic Phospholipase A2/C1P Interaction and Its Role in Eicosanoid Synthesis and Inflammation
… of group IVA cytosolic phospholipase A2 and ceramide-1-phosphate is crucial for production of eicosanoid synthesis in inflammation. Inflammation is a critical component of many disease states including anaphylaxis, cancer, cardiovascular disease, rheumatoid arthritis, diabetes and asthma. …
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Detection of colorectal carcinoma-associated antigens using specific antibodies against human milk oligosaccharides
… cell line SW'lll6. Sialyltetrasaccharide b-ceramide was detected in the monosialylganglioside fraction from human meconium and a total ganglioside fraction from SWlll6 cells on thin layer chromatograms by radioimmune staining using anti-sialyltetrasaccharide . b. Sialyltetrasaccharide …
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Protein-lipid interactions in raft-exhibiting membranes probed by combined AFM and FCS
… (FCS) and ii) the study of the effects of ceramide in the lateral organization of model plasma membranes. We described one of the first simultaneous applications of AFM and FCS on biologically relevant systems. More specifically, model membranes showing complex phase separation were …
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Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth
… to apoptosis induced by phorbol esters or C2-ceramide. Moreover, overexpression of PKCa, PKCd or PKCe sensitises both androgen-dependent and androgen-independent prostate cancer cells to phorbol ester-induced cell-death. The apoptotic effects of PKCd and PKCq in neuroblastoma cells are …
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Ceramides as Therapeutic Targets in Bronchopulmonary Dysplasia
… clear. Recent works suggest the up regulation of ceramides in the injured lung as a potentially key factor. Ceramides regulate tissue growth pathways, by increasing autophagy and apoptosis. Ceramides are increased in tracheal aspirates of preterm infants receiving MV. Moreover, attenuation of …
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